Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors Exhibit Bactericidal Activity against Planktonic and Biofilm Staphylococcus aureus In Vitro

Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors Exhibit Bactericidal Activity against Planktonic and Biofilm Staphylococcus aureus In Vitro

ABSTRACT The development of novel treatments for Staphylococcus aureus infections remains a high priority worldwide. We previously reported compounds 0147 and 0186, novel bacterial topoisomerase inhibitors (NBTIs) with potent antibacterial activity against S. aureus, including methicillin-resistant...

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Bibliographic Details
Main Authors: Anna Chen, Sheri Dellos-Nolan, Yanran Lu, Jason S. West, Daniel J. Wozniak, Mark J. Mitton-Fry
Format: Article
Language:English
Published: American Society for Microbiology 2022-12-01
Series:Microbiology Spectrum
Subjects:
biofilm
Staphylococcus
topoisomerase
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02056-22

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