A Case of Malignant Peripheral Nerve Sheath Tumor of the Hypoglossal Nerve after Stereotactic Radiosurgery Treatment
Abstract Objectives Hypoglossal schwannomas are rare. Surgical resection has been the standard treatment modality. Radiosurgery has been increasingly used for treatment. Radiation-associated secondary malignancy/malignant transformation has not been documented in the literature for the...
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| Format: | Article |
| Language: | English |
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Georg Thieme Verlag KG
2014-05-01
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| Series: | Journal of Neurological Surgery Reports |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0033-1358797 |
| _version_ | 1818246834212044800 |
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| author | Tong Yang Gordana Juric-Sekhar Donald Born Laligam N. Sekhar |
| author_facet | Tong Yang Gordana Juric-Sekhar Donald Born Laligam N. Sekhar |
| author_sort | Tong Yang |
| collection | DOAJ |
| description | Abstract
Objectives Hypoglossal schwannomas are rare. Surgical resection has been the standard treatment modality. Radiosurgery has been increasingly used for treatment. Radiation-associated secondary malignancy/malignant transformation has not been documented in the literature for the treatment of nonvestibular schwannomas.
Setting The patient was a 52-year-old man with an enlarging high cervical/skull base lesion 8.5 years after CyberKnife treatment of a presumed vagal schwannoma. A decision was made for surgical resection, and the tumor was found to originate from the hypoglossal nerve intraoperatively. Final pathology diagnosis was malignant peripheral nerve sheath tumor.
Results Patient had a gross total resection. Three months after resection, he received fractionated radiation of 50 Gy in 25 fractions and a boost gamma knife radiosurgery of 10 Gy to the 50% isodose surface. He remained tumor free on repeat magnetic resonance imaging 9 months after the resection.
Conclusion Although extremely rare, radiation treatment of nonvestibular schwannomas can potentially cause malignant transformation. |
| first_indexed | 2024-12-12T14:55:06Z |
| format | Article |
| id | doaj.art-d5b1212a5adb4b39abde9c7cb18edf41 |
| institution | Directory Open Access Journal |
| issn | 2193-6358 2193-6366 |
| language | English |
| last_indexed | 2024-12-12T14:55:06Z |
| publishDate | 2014-05-01 |
| publisher | Georg Thieme Verlag KG |
| record_format | Article |
| series | Journal of Neurological Surgery Reports |
| spelling | doaj.art-d5b1212a5adb4b39abde9c7cb18edf412022-12-22T00:20:56ZengGeorg Thieme Verlag KGJournal of Neurological Surgery Reports2193-63582193-63662014-05-017501e42e4610.1055/s-0033-1358797A Case of Malignant Peripheral Nerve Sheath Tumor of the Hypoglossal Nerve after Stereotactic Radiosurgery TreatmentTong Yang0Gordana Juric-Sekhar1Donald Born2Laligam N. Sekhar3Department of Neurosurgery, University of Washington, School of Medicine, Seattle, Washington, United StatesDepartment of Pathology, University of Washington, School of Medicine, Seattle, Washington, United StatesDepartment of Pathology, University of Washington, School of Medicine, Seattle, Washington, United StatesDepartment of Neurosurgery, University of Washington, School of Medicine, Seattle, Washington, United StatesAbstract Objectives Hypoglossal schwannomas are rare. Surgical resection has been the standard treatment modality. Radiosurgery has been increasingly used for treatment. Radiation-associated secondary malignancy/malignant transformation has not been documented in the literature for the treatment of nonvestibular schwannomas. Setting The patient was a 52-year-old man with an enlarging high cervical/skull base lesion 8.5 years after CyberKnife treatment of a presumed vagal schwannoma. A decision was made for surgical resection, and the tumor was found to originate from the hypoglossal nerve intraoperatively. Final pathology diagnosis was malignant peripheral nerve sheath tumor. Results Patient had a gross total resection. Three months after resection, he received fractionated radiation of 50 Gy in 25 fractions and a boost gamma knife radiosurgery of 10 Gy to the 50% isodose surface. He remained tumor free on repeat magnetic resonance imaging 9 months after the resection. Conclusion Although extremely rare, radiation treatment of nonvestibular schwannomas can potentially cause malignant transformation.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0033-1358797malignant peripheral nerve sheath tumornonvestibular schwannomaradiation associated malignancystereotactic radiosurgery |
| spellingShingle | Tong Yang Gordana Juric-Sekhar Donald Born Laligam N. Sekhar A Case of Malignant Peripheral Nerve Sheath Tumor of the Hypoglossal Nerve after Stereotactic Radiosurgery Treatment Journal of Neurological Surgery Reports malignant peripheral nerve sheath tumor nonvestibular schwannoma radiation associated malignancy stereotactic radiosurgery |
| title | A Case of Malignant Peripheral Nerve Sheath Tumor of the Hypoglossal Nerve after Stereotactic Radiosurgery Treatment |
| title_full | A Case of Malignant Peripheral Nerve Sheath Tumor of the Hypoglossal Nerve after Stereotactic Radiosurgery Treatment |
| title_fullStr | A Case of Malignant Peripheral Nerve Sheath Tumor of the Hypoglossal Nerve after Stereotactic Radiosurgery Treatment |
| title_full_unstemmed | A Case of Malignant Peripheral Nerve Sheath Tumor of the Hypoglossal Nerve after Stereotactic Radiosurgery Treatment |
| title_short | A Case of Malignant Peripheral Nerve Sheath Tumor of the Hypoglossal Nerve after Stereotactic Radiosurgery Treatment |
| title_sort | case of malignant peripheral nerve sheath tumor of the hypoglossal nerve after stereotactic radiosurgery treatment |
| topic | malignant peripheral nerve sheath tumor nonvestibular schwannoma radiation associated malignancy stereotactic radiosurgery |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0033-1358797 |
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