Oxymatrine combined with rapamycin to attenuate acute cardiac allograft rejection

Oxymatrine combined with rapamycin to attenuate acute cardiac allograft rejection

Background and aim: Solid organ transplantation remains a life-saving therapeutic option for patients with end-stage organ dysfunction. Acute cellular rejection (ACR), dominated by dendritic cells (DCs) and CD4+ T cells, is a major cause of post-transplant mortality. Inhibiting DC maturation and dir...

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Bibliographic Details
Main Authors: Xu Lan, Jingyi Zhang, Shaohua Ren, Hongda Wang, Bo Shao, Yafei Qin, Hong Qin, Chenglu Sun, Yanglin Zhu, Guangming Li, Hao Wang
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Heliyon
Subjects:
Oxymatrine
Acute allograft rejection
Immunoregulation
mTOR–HIF–1α signaling pathway
Mice
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024054793

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