A Novel, Dynamic Pattern-based Analysis of NF-kB Binding During the Priming Phase of Liver Regeneration Reveals Switch-Like Functional Regulation of Target Genes

A Novel, Dynamic Pattern-based Analysis of NF-kB Binding During the Priming Phase of Liver Regeneration Reveals Switch-Like Functional Regulation of Target Genes

Following partial hepatectomy, a coordinated series of molecular events occurs to regulate hepatocyte entry into the cell cycle to recover lost mass. In rats during the first six hours following resection, hepatocytes are primed by a tightly controlled cytokine response to prepare hepatocytes to beg...

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Bibliographic Details
Main Authors: Daniel J Cook, Biswanath ePatra, Lakshmi eKuttippurathu, Jan B Hoek, Rajanikanth eVadigepalli
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-07-01
Series:Frontiers in Physiology
Subjects:
Liver Regeneration
NF-kappa B
Transcription Factors
priming
ChIP-chip
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00189/full

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