Pectin nanoparticles loaded with nitric oxide donor drug: A potential approach for tissue regeneration
The process of wound healing and tissue regeneration involves several key mechanisms to ensure the production of new tissues with similar cellular functions. This study investigates the impact of pectin, a natural polysaccharide, and nebivolol hydrochloride (NBV), a nitric oxide (NO) donor drug, on...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | International Journal of Pharmaceutics: X |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590156724000161 |
| _version_ | 1797221792891273216 |
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| author | Noha I. Elsherif Abdulaziz M. Al-Mahallawi Iman Saad Ahmed Rehab N. Shamma |
| author_facet | Noha I. Elsherif Abdulaziz M. Al-Mahallawi Iman Saad Ahmed Rehab N. Shamma |
| author_sort | Noha I. Elsherif |
| collection | DOAJ |
| description | The process of wound healing and tissue regeneration involves several key mechanisms to ensure the production of new tissues with similar cellular functions. This study investigates the impact of pectin, a natural polysaccharide, and nebivolol hydrochloride (NBV), a nitric oxide (NO) donor drug, on wound healing. Utilizing ionotropic gelation, NBV-loaded pectin nanoparticles were developed following a 2231 full factorial design. The optimized formulation, determined using Design expert® software, exhibited an encapsulation efficiency percentage of 70.68%, zeta potential of −51.4 mV, and a particle size of 572 nm, characterized by a spherical, discrete morphology. An in vivo study was conducted to evaluate the effectiveness of the optimal formulation in wound healing compared to various controls. The results demonstrated the enhanced ability of the optimal formulation to accelerate wound healing. Moreover, histopathological examination further confirmed the formulation's benefits in tissue proliferation and collagen deposition at the wound site 15 days post-injury. This suggests that the developed formulation not only promotes faster healing but does so with minimal side effects, positioning it as a promising agent for effective wound healing and tissue regeneration. |
| first_indexed | 2024-04-24T13:11:04Z |
| format | Article |
| id | doaj.art-d5b470a58e3942f596ccc8ee0103bdd8 |
| institution | Directory Open Access Journal |
| issn | 2590-1567 |
| language | English |
| last_indexed | 2024-04-24T13:11:04Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Pharmaceutics: X |
| spelling | doaj.art-d5b470a58e3942f596ccc8ee0103bdd82024-04-05T04:41:30ZengElsevierInternational Journal of Pharmaceutics: X2590-15672024-06-017100244Pectin nanoparticles loaded with nitric oxide donor drug: A potential approach for tissue regenerationNoha I. Elsherif0Abdulaziz M. Al-Mahallawi1Iman Saad Ahmed2Rehab N. Shamma3Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Heliopolis University, Cairo 11785, EgyptDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo 12613, Egypt; School of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation, New Administrative Capital, Cairo 11835, EgyptDepartment of Pharmaceutics & Pharmaceutical Technology, College of Pharmacy, University of Sharjah, Sharjah 27272, United Arab Emirates; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah 27272, United Arab EmiratesDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo 12613, Egypt; Corresponding author.The process of wound healing and tissue regeneration involves several key mechanisms to ensure the production of new tissues with similar cellular functions. This study investigates the impact of pectin, a natural polysaccharide, and nebivolol hydrochloride (NBV), a nitric oxide (NO) donor drug, on wound healing. Utilizing ionotropic gelation, NBV-loaded pectin nanoparticles were developed following a 2231 full factorial design. The optimized formulation, determined using Design expert® software, exhibited an encapsulation efficiency percentage of 70.68%, zeta potential of −51.4 mV, and a particle size of 572 nm, characterized by a spherical, discrete morphology. An in vivo study was conducted to evaluate the effectiveness of the optimal formulation in wound healing compared to various controls. The results demonstrated the enhanced ability of the optimal formulation to accelerate wound healing. Moreover, histopathological examination further confirmed the formulation's benefits in tissue proliferation and collagen deposition at the wound site 15 days post-injury. This suggests that the developed formulation not only promotes faster healing but does so with minimal side effects, positioning it as a promising agent for effective wound healing and tissue regeneration.http://www.sciencedirect.com/science/article/pii/S2590156724000161PectinNebivolol hydrochlorideWound healingTissue regenerationNanoparticle |
| spellingShingle | Noha I. Elsherif Abdulaziz M. Al-Mahallawi Iman Saad Ahmed Rehab N. Shamma Pectin nanoparticles loaded with nitric oxide donor drug: A potential approach for tissue regeneration International Journal of Pharmaceutics: X Pectin Nebivolol hydrochloride Wound healing Tissue regeneration Nanoparticle |
| title | Pectin nanoparticles loaded with nitric oxide donor drug: A potential approach for tissue regeneration |
| title_full | Pectin nanoparticles loaded with nitric oxide donor drug: A potential approach for tissue regeneration |
| title_fullStr | Pectin nanoparticles loaded with nitric oxide donor drug: A potential approach for tissue regeneration |
| title_full_unstemmed | Pectin nanoparticles loaded with nitric oxide donor drug: A potential approach for tissue regeneration |
| title_short | Pectin nanoparticles loaded with nitric oxide donor drug: A potential approach for tissue regeneration |
| title_sort | pectin nanoparticles loaded with nitric oxide donor drug a potential approach for tissue regeneration |
| topic | Pectin Nebivolol hydrochloride Wound healing Tissue regeneration Nanoparticle |
| url | http://www.sciencedirect.com/science/article/pii/S2590156724000161 |
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