Indwelling stents cause severe inflammation and fibrosis of the ureter via urothelial–mesenchymal transition

Abstract To explore the pathways and mechanisms driving inflammation and fibrosis in stented ureters. In total, six healthy female pigs underwent cystoscopic unilateral ureteral stent insertion (6 Fr). After 14 days indwelling time, ureteral tissue was harvested in three pigs, while the remaining th...

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Bibliographic Details
Main Authors: Alina Reicherz, Felipe Eltit, Kymora Scotland, Khaled Almutairi, Robert Bell, Bita Mojtahedzadeh, Michael Cox, Ben Chew, Dirk Lange
Format: Article
Language:English
Published: Nature Portfolio 2023-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-31885-1