Development and validation of a dementia risk score in the UK Biobank and Whitehall II cohorts

Development and validation of a dementia risk score in the UK Biobank and Whitehall II cohorts

Background Current dementia risk scores have had limited success in consistently identifying at-risk individuals across different ages and geographical locations.Objective We aimed to develop and validate a novel dementia risk score for a midlife UK population, using two cohorts: the UK Biobank, and...

Full description

Bibliographic Details
Main Authors:	Mika Kivimäki, Archana Singh-Manoux, Georgios Georgiopoulos, James H Cole, Anya Topiwala, Danielle Newby, Melis Anatürk, Raihaan Patel, Klaus P. Ebmeier, Ann-Marie G de Lange, Michelle G Jansen, Sana Suri
Format:	Article
Language:	English
Published:	BMJ Publishing Group 2023-10-01
Series:	BMJ Mental Health
Online Access:	https://ebmh.bmj.com/content/26/1/e300719.full

Similar Items

Development and validation of a dementia risk score in the UK Biobank and Whitehall II Cohorts
by: Anatürk, M, et al.
Published: (2023)

Multimodal brain-age prediction and cardiovascular risk: The Whitehall II MRI sub-study
by: Ann-Marie G. de Lange, et al.
Published: (2020-11-01)

Multimodal brain-age prediction and cardiovascular risk: the Whitehall II MRI sub-study
by: de Lange, A-MG, et al.
Published: (2020)

Leisure Activities and Their Relationship With MRI Measures of Brain Structure, Functional Connectivity, and Cognition in the UK Biobank Cohort
by: Melis Anatürk, et al.
Published: (2021-11-01)

Association of trajectories of depressive symptoms with vascular risk, cognitive function and adverse brain outcomes: The Whitehall II MRI sub-study
by: Demnitz, N, et al.
Published: (2020)

Is metabolic-healthy obesity associated with risk of dementia? An age-stratified analysis of the Whitehall II cohort study
by: Marcos D. Machado-Fragua, et al.
Published: (2023-11-01)

Integrating large-scale neuroimaging research datasets: Harmonisation of white matter hyperintensity measurements across Whitehall and UK Biobank datasets
by: Valentina Bordin, et al.
Published: (2021-08-01)

Longitudinal mid-life stroke risk predicts brain structure in the aging whitehall II cohort
by: Zsoldos, E, et al.
Published: (2019)

Contribution of smoking towards the association between socioeconomic position and dementia: 32-year follow-up of the Whitehall II prospective cohort study
by: Martina Raggi, et al.
Published: (2022-12-01)

Association of ideal cardiovascular health at age 50 with incidence of dementia: 25 year follow-up of Whitehall II cohort study
by: Sabia, S, et al.
Published: (2019)

Integrating large-scale neuroimaging research datasets: harmonisation of white matter hyperintensity measurements across Whitehall and UK Biobank datasets
by: Bordin, V, et al.
Published: (2021)

Circulating serum metabolites as predictors of dementia: a machine learning approach in a 21-year follow-up of the Whitehall II cohort study
by: Marcos D. Machado-Fragua, et al.
Published: (2022-09-01)

Sub-threshold depressive symptoms and brain structure: A magnetic resonance imaging study within the Whitehall II cohort
by: Allan, C, et al.
Published: (2016)

Associations between arterial stiffening and brain structure, perfusion, and cognition in the Whitehall II Imaging Sub-study: A retrospective cohort study.
by: Sana Suri, et al.
Published: (2020-12-01)

Association of social contact with dementia and cognition: 28-year follow-up of the Whitehall II cohort study.
by: Andrew Sommerlad, et al.
Published: (2019-08-01)

Timing of onset of cognitive decline: Results from Whitehall II prospective cohort study
by: Singh-Manoux, A, et al.
Published: (2012)

Timing of onset of cognitive decline: results from Whitehall II prospective cohort study.
by: Singh-Manoux, A, et al.
Published: (2012)

Association of sleep duration at age 50, 60, and 70 years with risk of multimorbidity in the UK: 25-year follow-up of the Whitehall II cohort study.
by: Séverine Sabia, et al.
Published: (2022-10-01)

Association of sleep duration at age 50, 60, and 70 years with risk of multimorbidity in the UK: 25-year follow-up of the Whitehall II cohort study
by: Séverine Sabia, et al.
Published: (2022-10-01)

Trajectories of physical and mental functioning over 25 years before onset of frailty: results from the Whitehall II cohort study
by: Benjamin Landré, et al.
Published: (2023-02-01)

Physical Activity, Sedentary Behavior, and Long‐Term Changes in Aortic Stiffness: The Whitehall II Study
by: Sara Ahmadi‐Abhari, et al.
Published: (2017-08-01)

Study protocol: the Whitehall II imaging sub-study
by: Filippini, N, et al.
Published: (2014)

Allostatic load as a predictor of grey matter volume and white matter integrity in old age: The Whitehall II MRI study
by: Zsoldos, E, et al.
Published: (2018)

Leisure activities and their relationship with MRI measures of brain structure, functional connectivity and cognition in the UK Biobank cohort
by: Anaturk, M, et al.
Published: (2021)

Associations between arterial stiffening and brain structure, perfusion and cognition in the Whitehall II Imaging Sub-study: a retrospective cohort study
by: Suri, S, et al.
Published: (2020)

ASSOCIATION OF CEREBRAL SMALL VESSEL DISEASE BURDEN WITH BRAIN STRUCTURE AND COGNITIVE AND VASCULAR RISK TRAJECTORIES IN MID-TO-LATE LIFE
by: Michelle G. Jansen, et al.
Published: (2024-01-01)

Uncoupling protein 2 haplotype does not affect human brain structure and function in a sample of community-dwelling older adults.
by: Verena Heise, et al.
Published: (2017-01-01)

Study protocol: the Whitehall II imaging sub-study
by: Ebmeier, K
Published: (2014)

Inter- and intra-individual variation in brain structural-cognition relationships in aging
by: Raihaan Patel, et al.
Published: (2022-08-01)

Healthy behaviors at age 50 years and frailty at older ages in a 20-year follow-up of the UK Whitehall II cohort: A longitudinal study.
by: Andres Gil-Salcedo, et al.
Published: (2020-07-01)

Examining overweight and obesity as risk factors for common mental disorders using fat mass and obesity-associated (FTO) genotype-instrumented analysis: The Whitehall II Study, 1985-2004.
by: Kivimäki, M, et al.
Published: (2011)

Predicting cognitive resilience from midlife lifestyle and multi-modal MRI: A 30-year prospective cohort study.
by: Anya Topiwala, et al.
Published: (2019-01-01)

The lifetime accumulation of multimorbidity and its influence on dementia risk: a UK Biobank study
by: Patel, R, et al.
Published: (2024)

The joint effect of sleep duration and disturbed sleep on cause-specific mortality: results from the Whitehall II cohort study.
by: Naja Hulvej Rod, et al.
Published: (2014-01-01)

Alcohol consumption and MRI markers of brain structure and function: Cohort study of 25,378 UK Biobank participants
by: Anya Topiwala, et al.
Published: (2022-01-01)

Using structural and diffusion magnetic resonance imaging to differentiate the dementias.
by: Suri, S, et al.
Published: (2014)

Association between cannabis use and brain imaging phenotypes in UK Biobank: an observational and Mendelian randomization study
by: Ishrat, S, et al.
Published: (2023)

Prediction of brain age and cognitive age: quantifying brain and cognitive maintenance in aging
by: Anatürk, M, et al.
Published: (2020)

Adverse Childhood Experiences and the Risk of Coronary Heart Disease in Adulthood: Examining Potential Psychological, Biological, and Behavioral Mediators in the Whitehall II Cohort Study
by: Sonya S. Deschênes, et al.
Published: (2021-05-01)

Adiponectin, biomarkers of inflammation and changes in cardiac autonomic function: Whitehall II study
by: Christian Stevns Hansen, et al.
Published: (2017-12-01)