Tumor microenvironment affects exogenous sodium/iodide symporter expression

Tumor microenvironment affects exogenous sodium/iodide symporter expression

For decades, sodium/iodide symporter NIS-mediated iodide uptake has played a crucial role in the radioactive ablation of thyroid cancer cells. NIS-based gene therapy has also become a promising tool for the treatment of tumors of extrathyroidal origin. But its applicability has been hampered by redu...

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Bibliographic Details
Main Authors: Fabio Castillo-Rivera, Alejandro Ondo-Méndez, Julien Guglielmi, Jean-Marie Guigonis, Lun Jing, Sabine Lindenthal, Andrea Gonzalez, Diana López, Béatrice Cambien, Thierry Pourcher
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Translational Oncology
Subjects:
Sodium/Iodide symporter (NIS)
Tumor microenvironment
Quiescence
Hypoxia
Protein trafficking
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523320304290

Internet

http://www.sciencedirect.com/science/article/pii/S1936523320304290

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