The role of hematopoietic stem cell transplantation for type 1 diabetes mellitus O papel do transplante de célula-tronco hematopoética no diabetes mellitus tipo1
In this review, we present 1) scientific basis for the use of high dose immunosuppression followed by autologous peripheral blood hematopoietic stem cell transplantation for newly diagnosed type 1 diabetes mellitus, 2) an update of clinical and laboratory outcomes in 21 patients transplanted at the...
| Autors principals: | , , , , , , , , |
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| Format: | Article |
| Idioma: | English |
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Elsevier
2008-06-01
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| Col·lecció: | Revista Brasileira de Hematologia e Hemoterapia |
| Matèries: | |
| Accés en línia: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842008000800014 |
| _version_ | 1828184481925693440 |
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| author | Júlio C. Voltarelli Carlos Eduardo B. Couri Maria Carolina Rodrigues Ana Beatriz P. L. Stracieri Daniela A. Moraes Fabiano Pieroni George Navarro Maria Isabel A. Madeira Belinda P. Simões |
| author_facet | Júlio C. Voltarelli Carlos Eduardo B. Couri Maria Carolina Rodrigues Ana Beatriz P. L. Stracieri Daniela A. Moraes Fabiano Pieroni George Navarro Maria Isabel A. Madeira Belinda P. Simões |
| author_sort | Júlio C. Voltarelli |
| collection | DOAJ |
| description | In this review, we present 1) scientific basis for the use of high dose immunosuppression followed by autologous peripheral blood hematopoietic stem cell transplantation for newly diagnosed type 1 diabetes mellitus, 2) an update of clinical and laboratory outcomes in 21 patients transplanted at the University Hospital of the Ribeirão Preto Medical School, University of São Paulo, Brazil, including 6 relapses in patients without previous ketoacidosis and 3) a discussion of future prospectives of cellular therapy for type 1 diabetes mellitus.<br>Nesta revisão, são apresentadas: 1) as bases científicas para o uso de imunossupressão em alta dose seguida de transplante autólogo de células-tronco hematopoéticas do sangue periférico no diabete melito do tipo 1 recém-diagnosticado; 2) uma atualização da evolução clínica e laboratorial de 21 pacientes transplantados no Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, da Universidade de São Paulo, Brasil, incluindo recaídas em seis pacientes transplantados sem cetoacidose prévia; e 3) uma discussão das perspectivas futuras de terapia celular no diabete melito do tipo 1. |
| first_indexed | 2024-04-12T06:49:34Z |
| format | Article |
| id | doaj.art-d5c215a70e1b4e60b51b735005e96789 |
| institution | Directory Open Access Journal |
| issn | 1516-8484 1806-0870 |
| language | English |
| last_indexed | 2024-04-12T06:49:34Z |
| publishDate | 2008-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Revista Brasileira de Hematologia e Hemoterapia |
| spelling | doaj.art-d5c215a70e1b4e60b51b735005e967892022-12-22T03:43:24ZengElsevierRevista Brasileira de Hematologia e Hemoterapia1516-84841806-08702008-06-01305559The role of hematopoietic stem cell transplantation for type 1 diabetes mellitus O papel do transplante de célula-tronco hematopoética no diabetes mellitus tipo1Júlio C. VoltarelliCarlos Eduardo B. CouriMaria Carolina RodriguesAna Beatriz P. L. StracieriDaniela A. MoraesFabiano PieroniGeorge NavarroMaria Isabel A. MadeiraBelinda P. SimõesIn this review, we present 1) scientific basis for the use of high dose immunosuppression followed by autologous peripheral blood hematopoietic stem cell transplantation for newly diagnosed type 1 diabetes mellitus, 2) an update of clinical and laboratory outcomes in 21 patients transplanted at the University Hospital of the Ribeirão Preto Medical School, University of São Paulo, Brazil, including 6 relapses in patients without previous ketoacidosis and 3) a discussion of future prospectives of cellular therapy for type 1 diabetes mellitus.<br>Nesta revisão, são apresentadas: 1) as bases científicas para o uso de imunossupressão em alta dose seguida de transplante autólogo de células-tronco hematopoéticas do sangue periférico no diabete melito do tipo 1 recém-diagnosticado; 2) uma atualização da evolução clínica e laboratorial de 21 pacientes transplantados no Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, da Universidade de São Paulo, Brasil, incluindo recaídas em seis pacientes transplantados sem cetoacidose prévia; e 3) uma discussão das perspectivas futuras de terapia celular no diabete melito do tipo 1.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842008000800014Diabete melitoterapia celulartransplante de células-tronco hematopoéticasDiabetes mellituscellular therapyhematopoietic stem cell transplantation |
| spellingShingle | Júlio C. Voltarelli Carlos Eduardo B. Couri Maria Carolina Rodrigues Ana Beatriz P. L. Stracieri Daniela A. Moraes Fabiano Pieroni George Navarro Maria Isabel A. Madeira Belinda P. Simões The role of hematopoietic stem cell transplantation for type 1 diabetes mellitus O papel do transplante de célula-tronco hematopoética no diabetes mellitus tipo1 Revista Brasileira de Hematologia e Hemoterapia Diabete melito terapia celular transplante de células-tronco hematopoéticas Diabetes mellitus cellular therapy hematopoietic stem cell transplantation |
| title | The role of hematopoietic stem cell transplantation for type 1 diabetes mellitus O papel do transplante de célula-tronco hematopoética no diabetes mellitus tipo1 |
| title_full | The role of hematopoietic stem cell transplantation for type 1 diabetes mellitus O papel do transplante de célula-tronco hematopoética no diabetes mellitus tipo1 |
| title_fullStr | The role of hematopoietic stem cell transplantation for type 1 diabetes mellitus O papel do transplante de célula-tronco hematopoética no diabetes mellitus tipo1 |
| title_full_unstemmed | The role of hematopoietic stem cell transplantation for type 1 diabetes mellitus O papel do transplante de célula-tronco hematopoética no diabetes mellitus tipo1 |
| title_short | The role of hematopoietic stem cell transplantation for type 1 diabetes mellitus O papel do transplante de célula-tronco hematopoética no diabetes mellitus tipo1 |
| title_sort | role of hematopoietic stem cell transplantation for type 1 diabetes mellitus o papel do transplante de celula tronco hematopoetica no diabetes mellitus tipo1 |
| topic | Diabete melito terapia celular transplante de células-tronco hematopoéticas Diabetes mellitus cellular therapy hematopoietic stem cell transplantation |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842008000800014 |
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