Use of Dichlorodimethylsilane to Produce Polydimethylsiloxane as a Substitute for Vitreous Humour: Characteristics and In Vitro Toxicity
Polydimethylsiloxane (PDMS) is a substitute for vitreous humour in vitreoretinal surgery and is usually produced from octamethylcyclotetrasiloxane (D4). In Indonesia, both commercial PDMS and D4 are limited and expensive. Dichlorodimethylsilane (DCMS) can be an alternative to produce PDMS. DCMS is c...
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MDPI AG
2023-08-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/14/8/425 |
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| author | Diba Grace Auliya Ulfa Fauziah Vira Fuji Arini Soni Setiadji Fitrilawati Fitrilawati Arief Sjamsulaksan Kartasasmita Risdiana Risdiana |
| author_facet | Diba Grace Auliya Ulfa Fauziah Vira Fuji Arini Soni Setiadji Fitrilawati Fitrilawati Arief Sjamsulaksan Kartasasmita Risdiana Risdiana |
| author_sort | Diba Grace Auliya |
| collection | DOAJ |
| description | Polydimethylsiloxane (PDMS) is a substitute for vitreous humour in vitreoretinal surgery and is usually produced from octamethylcyclotetrasiloxane (D4). In Indonesia, both commercial PDMS and D4 are limited and expensive. Dichlorodimethylsilane (DCMS) can be an alternative to produce PDMS. DCMS is cheaper and easier to obtain than D4. However, more extra effort is needed in order to produce PDMS from DCMS. Therefore, this study aimed to produce PDMS from DCMS by varying the ratio of DCMS precursor to dichloromethane (DCM) solvent at ratios of 1:1 and 1:4 through the hydrolysis–condensation method under neutral conditions. The PDMS produced had medium- (2.06 Pa·s) and high viscosity (3.59 Pa·s), with densities ranging from 0.96 to 0.99 g/mL. The refractive index was 1.4034–1.4036 and surface tension was 21 × 10<sup>−3</sup> N/m, while they were able to transmit ~100% visible light, which were similar values to the commercial PDMS characteristics. PDMS samples were characterized using IR and NMR spectroscopy, which confirmed they were of PDMS type. The most optimum DCMS:DCM ratio was 1:1 due to the medium-viscosity PDMS type that could be produced. The in vitro HET–CAM toxicity test showed that samples were non-irritant, similar to PDMS produced from D4. PDMS from DCMS was non-toxic and ready to be used as a vitreous humuor substitution. |
| first_indexed | 2024-03-10T23:50:55Z |
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| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-10T23:50:55Z |
| publishDate | 2023-08-01 |
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| series | Journal of Functional Biomaterials |
| spelling | doaj.art-d5c44756e7a44ab3aed546136a3102b42023-11-19T01:43:20ZengMDPI AGJournal of Functional Biomaterials2079-49832023-08-0114842510.3390/jfb14080425Use of Dichlorodimethylsilane to Produce Polydimethylsiloxane as a Substitute for Vitreous Humour: Characteristics and In Vitro ToxicityDiba Grace Auliya0Ulfa Fauziah1Vira Fuji Arini2Soni Setiadji3Fitrilawati Fitrilawati4Arief Sjamsulaksan Kartasasmita5Risdiana Risdiana6Doctor Program in Biotechnology, Graduate School, Universitas Padjadjaran, Jl. Dipati Ukur No. 35, Bandung 40132, IndonesiaDepartment of Physics, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Ir. Soekarno km 21 Jatinangor, Sumedang 45363, IndonesiaDepartment of Physics, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Ir. Soekarno km 21 Jatinangor, Sumedang 45363, IndonesiaDepartment of Chemistry, Faculty of Sciences and Technology, UIN Sunan Gunung Djati Bandung, Jl. A. H. Nasution No. 105 Cibiru, Bandung 40614, IndonesiaDepartment of Physics, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Ir. Soekarno km 21 Jatinangor, Sumedang 45363, IndonesiaDepartment of Ophthalmology, Faculty of Medicine, Universitas Padjadjaran, Jl. Ir. Soekarno km 21 Jatinangor, Sumedang 45363, IndonesiaDepartment of Physics, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Ir. Soekarno km 21 Jatinangor, Sumedang 45363, IndonesiaPolydimethylsiloxane (PDMS) is a substitute for vitreous humour in vitreoretinal surgery and is usually produced from octamethylcyclotetrasiloxane (D4). In Indonesia, both commercial PDMS and D4 are limited and expensive. Dichlorodimethylsilane (DCMS) can be an alternative to produce PDMS. DCMS is cheaper and easier to obtain than D4. However, more extra effort is needed in order to produce PDMS from DCMS. Therefore, this study aimed to produce PDMS from DCMS by varying the ratio of DCMS precursor to dichloromethane (DCM) solvent at ratios of 1:1 and 1:4 through the hydrolysis–condensation method under neutral conditions. The PDMS produced had medium- (2.06 Pa·s) and high viscosity (3.59 Pa·s), with densities ranging from 0.96 to 0.99 g/mL. The refractive index was 1.4034–1.4036 and surface tension was 21 × 10<sup>−3</sup> N/m, while they were able to transmit ~100% visible light, which were similar values to the commercial PDMS characteristics. PDMS samples were characterized using IR and NMR spectroscopy, which confirmed they were of PDMS type. The most optimum DCMS:DCM ratio was 1:1 due to the medium-viscosity PDMS type that could be produced. The in vitro HET–CAM toxicity test showed that samples were non-irritant, similar to PDMS produced from D4. PDMS from DCMS was non-toxic and ready to be used as a vitreous humuor substitution.https://www.mdpi.com/2079-4983/14/8/425DCMDCMShigh viscosityhydrolysis–condensationin vitro toxicitymedium viscosity |
| spellingShingle | Diba Grace Auliya Ulfa Fauziah Vira Fuji Arini Soni Setiadji Fitrilawati Fitrilawati Arief Sjamsulaksan Kartasasmita Risdiana Risdiana Use of Dichlorodimethylsilane to Produce Polydimethylsiloxane as a Substitute for Vitreous Humour: Characteristics and In Vitro Toxicity Journal of Functional Biomaterials DCM DCMS high viscosity hydrolysis–condensation in vitro toxicity medium viscosity |
| title | Use of Dichlorodimethylsilane to Produce Polydimethylsiloxane as a Substitute for Vitreous Humour: Characteristics and In Vitro Toxicity |
| title_full | Use of Dichlorodimethylsilane to Produce Polydimethylsiloxane as a Substitute for Vitreous Humour: Characteristics and In Vitro Toxicity |
| title_fullStr | Use of Dichlorodimethylsilane to Produce Polydimethylsiloxane as a Substitute for Vitreous Humour: Characteristics and In Vitro Toxicity |
| title_full_unstemmed | Use of Dichlorodimethylsilane to Produce Polydimethylsiloxane as a Substitute for Vitreous Humour: Characteristics and In Vitro Toxicity |
| title_short | Use of Dichlorodimethylsilane to Produce Polydimethylsiloxane as a Substitute for Vitreous Humour: Characteristics and In Vitro Toxicity |
| title_sort | use of dichlorodimethylsilane to produce polydimethylsiloxane as a substitute for vitreous humour characteristics and in vitro toxicity |
| topic | DCM DCMS high viscosity hydrolysis–condensation in vitro toxicity medium viscosity |
| url | https://www.mdpi.com/2079-4983/14/8/425 |
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