Anticancer potential of phytochemicals against breast cancer: Molecular docking and simulation approach
Breast cancer malignancy is prevailing among the women not only from the developing countries but also from the developed one at the rate of 18% of total population worldwide. One of the main causes of breast cancer is estrogen receptor alpha. Overexpression of estrogen receptor is seen in number of...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Bangladesh Pharmacological Society
2014-10-01
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| Series: | Bangladesh Journal of Pharmacology |
| Subjects: | |
| Online Access: | https://www.banglajol.info/index.php/BJP/article/view/20412 |
| _version_ | 1811328859825504256 |
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| author | Bilal Ahmed Usman Ali Ashfaq Muhammad Tahir ul Qamar Matloob Ahmad |
| author_facet | Bilal Ahmed Usman Ali Ashfaq Muhammad Tahir ul Qamar Matloob Ahmad |
| author_sort | Bilal Ahmed |
| collection | DOAJ |
| description | Breast cancer malignancy is prevailing among the women not only from the developing countries but also from the developed one at the rate of 18% of total population worldwide. One of the main causes of breast cancer is estrogen receptor alpha. Overexpression of estrogen receptor is seen in number of cases of breast cancer. Tamoxifen was used as a reference drug in present study. Almost 80,000 species of plants are used as a source of medicines. Current study was totally based on the screening of phytochemicals to find out the biomolecules having strong bonding actions as compared to tamoxifen. Present study exhibited that 10 molecules (kushenol K, silybin, taxifolin 3-O-acetate, rosemarinic acid, secundifloran, kushenol N, kurarinol, podophyllotoxone, AC1LCW2L, leachianone G) have successful and potential binding with the target molecule as compared to tamoxifen. These molecules can be used for the treatment of breast cancer and birth control. |
| first_indexed | 2024-04-13T15:33:36Z |
| format | Article |
| id | doaj.art-d5c4fc1c785843f48bbe2caf59305557 |
| institution | Directory Open Access Journal |
| issn | 1991-0088 |
| language | English |
| last_indexed | 2024-04-13T15:33:36Z |
| publishDate | 2014-10-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| series | Bangladesh Journal of Pharmacology |
| spelling | doaj.art-d5c4fc1c785843f48bbe2caf593055572022-12-22T02:41:19ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882014-10-0194Anticancer potential of phytochemicals against breast cancer: Molecular docking and simulation approachBilal Ahmed0Usman Ali Ashfaq1Muhammad Tahir ul Qamar2Matloob Ahmad3Department of Bioinformatics and Biotechnology, Government College University (GCU), FaisalabadDepartment of Bioinformatics and Biotechnology, Government College University (GCU), FaisalabadDepartment of Bioinformatics and Biotechnology, Government College University (GCU), FaisalabadDepartment of Chemistry, Government College University, FaisalabadBreast cancer malignancy is prevailing among the women not only from the developing countries but also from the developed one at the rate of 18% of total population worldwide. One of the main causes of breast cancer is estrogen receptor alpha. Overexpression of estrogen receptor is seen in number of cases of breast cancer. Tamoxifen was used as a reference drug in present study. Almost 80,000 species of plants are used as a source of medicines. Current study was totally based on the screening of phytochemicals to find out the biomolecules having strong bonding actions as compared to tamoxifen. Present study exhibited that 10 molecules (kushenol K, silybin, taxifolin 3-O-acetate, rosemarinic acid, secundifloran, kushenol N, kurarinol, podophyllotoxone, AC1LCW2L, leachianone G) have successful and potential binding with the target molecule as compared to tamoxifen. These molecules can be used for the treatment of breast cancer and birth control.https://www.banglajol.info/index.php/BJP/article/view/20412Breast cancerEstrogen receptorMolecular Docking |
| spellingShingle | Bilal Ahmed Usman Ali Ashfaq Muhammad Tahir ul Qamar Matloob Ahmad Anticancer potential of phytochemicals against breast cancer: Molecular docking and simulation approach Bangladesh Journal of Pharmacology Breast cancer Estrogen receptor Molecular Docking |
| title | Anticancer potential of phytochemicals against breast cancer: Molecular docking and simulation approach |
| title_full | Anticancer potential of phytochemicals against breast cancer: Molecular docking and simulation approach |
| title_fullStr | Anticancer potential of phytochemicals against breast cancer: Molecular docking and simulation approach |
| title_full_unstemmed | Anticancer potential of phytochemicals against breast cancer: Molecular docking and simulation approach |
| title_short | Anticancer potential of phytochemicals against breast cancer: Molecular docking and simulation approach |
| title_sort | anticancer potential of phytochemicals against breast cancer molecular docking and simulation approach |
| topic | Breast cancer Estrogen receptor Molecular Docking |
| url | https://www.banglajol.info/index.php/BJP/article/view/20412 |
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