Efficient and accurate frailty model approach for genome-wide survival association analysis in large-scale biobanks
The proliferation of large biobanks necessitates statistical methods designed for genetic analysis on biobank data. Here, the authors have developed a frailty model-based method for GWAS analysis of time-to-event phenotypes in large biobanks that accounts for relatedness in samples and censoring of...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32885-x |
| _version_ | 1798036269389840384 |
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| author | Rounak Dey Wei Zhou Tuomo Kiiskinen Aki Havulinna Amanda Elliott Juha Karjalainen Mitja Kurki Ashley Qin FinnGen Seunggeun Lee Aarno Palotie Benjamin Neale Mark Daly Xihong Lin |
| author_facet | Rounak Dey Wei Zhou Tuomo Kiiskinen Aki Havulinna Amanda Elliott Juha Karjalainen Mitja Kurki Ashley Qin FinnGen Seunggeun Lee Aarno Palotie Benjamin Neale Mark Daly Xihong Lin |
| author_sort | Rounak Dey |
| collection | DOAJ |
| description | The proliferation of large biobanks necessitates statistical methods designed for genetic analysis on biobank data. Here, the authors have developed a frailty model-based method for GWAS analysis of time-to-event phenotypes in large biobanks that accounts for relatedness in samples and censoring of phenotypes. |
| first_indexed | 2024-04-11T21:10:20Z |
| format | Article |
| id | doaj.art-d5c668ffbd4f4616b207a2e2f83a3fc0 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T21:10:20Z |
| publishDate | 2022-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d5c668ffbd4f4616b207a2e2f83a3fc02022-12-22T04:03:03ZengNature PortfolioNature Communications2041-17232022-09-0113111310.1038/s41467-022-32885-xEfficient and accurate frailty model approach for genome-wide survival association analysis in large-scale biobanksRounak Dey0Wei Zhou1Tuomo Kiiskinen2Aki Havulinna3Amanda Elliott4Juha Karjalainen5Mitja Kurki6Ashley Qin7FinnGenSeunggeun Lee8Aarno Palotie9Benjamin Neale10Mark Daly11Xihong Lin12Department of Biostatistics, Harvard T.H. Chan School of Public HealthAnalytic and Translational Genetics Unit, Massachusetts General HospitalInstitute for Molecular Medicine Finland, Helsinki Institute of Life Sciences, University of HelsinkiInstitute for Molecular Medicine Finland, Helsinki Institute of Life Sciences, University of HelsinkiDepartment of Biostatistics, Harvard T.H. Chan School of Public HealthAnalytic and Translational Genetics Unit, Massachusetts General HospitalAnalytic and Translational Genetics Unit, Massachusetts General HospitalDepartment of Biostatistics, Harvard T.H. Chan School of Public HealthGraduate School of Data Science, Seoul National UniversityAnalytic and Translational Genetics Unit, Massachusetts General HospitalAnalytic and Translational Genetics Unit, Massachusetts General HospitalAnalytic and Translational Genetics Unit, Massachusetts General HospitalDepartment of Biostatistics, Harvard T.H. Chan School of Public HealthThe proliferation of large biobanks necessitates statistical methods designed for genetic analysis on biobank data. Here, the authors have developed a frailty model-based method for GWAS analysis of time-to-event phenotypes in large biobanks that accounts for relatedness in samples and censoring of phenotypes.https://doi.org/10.1038/s41467-022-32885-x |
| spellingShingle | Rounak Dey Wei Zhou Tuomo Kiiskinen Aki Havulinna Amanda Elliott Juha Karjalainen Mitja Kurki Ashley Qin FinnGen Seunggeun Lee Aarno Palotie Benjamin Neale Mark Daly Xihong Lin Efficient and accurate frailty model approach for genome-wide survival association analysis in large-scale biobanks Nature Communications |
| title | Efficient and accurate frailty model approach for genome-wide survival association analysis in large-scale biobanks |
| title_full | Efficient and accurate frailty model approach for genome-wide survival association analysis in large-scale biobanks |
| title_fullStr | Efficient and accurate frailty model approach for genome-wide survival association analysis in large-scale biobanks |
| title_full_unstemmed | Efficient and accurate frailty model approach for genome-wide survival association analysis in large-scale biobanks |
| title_short | Efficient and accurate frailty model approach for genome-wide survival association analysis in large-scale biobanks |
| title_sort | efficient and accurate frailty model approach for genome wide survival association analysis in large scale biobanks |
| url | https://doi.org/10.1038/s41467-022-32885-x |
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