Dendritic Cell-Targeted Vaccines
Despite significant effort, the development of effective vaccines inducing strong and durable T cell responses against intracellular pathogens and cancer cells has remained a challenge. The initiation of effector CD8+ T cell responses requires the presentation of peptides derived from internalized a...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-05-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00255/full |
| _version_ | 1818358722464841728 |
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| author | Lelia eDelamarre Lillian eCohn |
| author_facet | Lelia eDelamarre Lillian eCohn |
| author_sort | Lelia eDelamarre |
| collection | DOAJ |
| description | Despite significant effort, the development of effective vaccines inducing strong and durable T cell responses against intracellular pathogens and cancer cells has remained a challenge. The initiation of effector CD8+ T cell responses requires the presentation of peptides derived from internalized antigen on class I MHC molecules by dendritic cells (DCs) in a process called cross-presentation. A current strategy to enhance the effectiveness of vaccination is to deliver antigens directly to DCs. This is done via selective targeting of antigen using monoclonal antibodies directed against endocytic receptors on the surface of the DCs. In this review we will discuss considerations relevant to the design of such vaccines: the existence of DC subsets with specialized functions, the impact of the antigen intracellular trafficking on cross-presentation, and the influence of maturation signals received by DCs on the outcome of the immune response. |
| first_indexed | 2024-12-13T20:33:31Z |
| format | Article |
| id | doaj.art-d5c6a4625a164ae58ae58ae61c3b1eb4 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-13T20:33:31Z |
| publishDate | 2014-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-d5c6a4625a164ae58ae58ae61c3b1eb42022-12-21T23:32:22ZengFrontiers Media S.A.Frontiers in Immunology1664-32242014-05-01510.3389/fimmu.2014.0025585832Dendritic Cell-Targeted VaccinesLelia eDelamarre0Lillian eCohn1GenentechRockefeller UniversityDespite significant effort, the development of effective vaccines inducing strong and durable T cell responses against intracellular pathogens and cancer cells has remained a challenge. The initiation of effector CD8+ T cell responses requires the presentation of peptides derived from internalized antigen on class I MHC molecules by dendritic cells (DCs) in a process called cross-presentation. A current strategy to enhance the effectiveness of vaccination is to deliver antigens directly to DCs. This is done via selective targeting of antigen using monoclonal antibodies directed against endocytic receptors on the surface of the DCs. In this review we will discuss considerations relevant to the design of such vaccines: the existence of DC subsets with specialized functions, the impact of the antigen intracellular trafficking on cross-presentation, and the influence of maturation signals received by DCs on the outcome of the immune response.http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00255/fullAdjuvants, ImmunologicVaccinationMHC class ICD8+ T cellsdendric cells |
| spellingShingle | Lelia eDelamarre Lillian eCohn Dendritic Cell-Targeted Vaccines Frontiers in Immunology Adjuvants, Immunologic Vaccination MHC class I CD8+ T cells dendric cells |
| title | Dendritic Cell-Targeted Vaccines |
| title_full | Dendritic Cell-Targeted Vaccines |
| title_fullStr | Dendritic Cell-Targeted Vaccines |
| title_full_unstemmed | Dendritic Cell-Targeted Vaccines |
| title_short | Dendritic Cell-Targeted Vaccines |
| title_sort | dendritic cell targeted vaccines |
| topic | Adjuvants, Immunologic Vaccination MHC class I CD8+ T cells dendric cells |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00255/full |
| work_keys_str_mv | AT leliaedelamarre dendriticcelltargetedvaccines AT lillianecohn dendriticcelltargetedvaccines |