DCTPP1, an Oncogene Regulated by miR-378a-3p, Promotes Proliferation of Breast Cancer via DNA Repair Signaling Pathway
Breast cancer (BRCA) is one of the most deadly cancers worldwide, with poor survival rates that could be due to its high proliferation. Human all-alpha dCTP pyrophosphatase 1 (DCTPP1) is implicated in numerous diseases, including cancers. However, its role in BRCA is unclear. In this study, we used...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-05-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.641931/full |
| _version_ | 1818864031288524800 |
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| author | Ming Niu Ming Shan Yang Liu Yanni Song Ji-guang Han Shanshan Sun Xiao-shuan Liang Guo-qiang Zhang |
| author_facet | Ming Niu Ming Shan Yang Liu Yanni Song Ji-guang Han Shanshan Sun Xiao-shuan Liang Guo-qiang Zhang |
| author_sort | Ming Niu |
| collection | DOAJ |
| description | Breast cancer (BRCA) is one of the most deadly cancers worldwide, with poor survival rates that could be due to its high proliferation. Human all-alpha dCTP pyrophosphatase 1 (DCTPP1) is implicated in numerous diseases, including cancers. However, its role in BRCA is unclear. In this study, we used bioinformatic analyses of the ONCOMINE, UALCAN, and GEPIA databases to determine the expression pattern of DCTPP1 in BRCA. We found that elevated DCTPP1 levels correlate with poor BRCA prognosis. DCTPP1 silencing inhibited BRCA cell proliferation and induced apoptosis in vitro, as well as in vivo. Our data show that this tumorigenic effect depends on DNA repair signaling. Moreover, we found that DCTPP1 is directly modulated by miR-378a-3p, whose downregulation is linked to BRCA progression. Our results showed down-regulation of miR-378a-3p in BRCA. Upregulation of miR-378a-3p, on the other hand, can inhibit BRCA cell growth and proliferation. This study shows that reduced miR-378a-3p level enhances DCTPP1 expression in BRCA, which promotes proliferation by activating DNA repair signaling in BRCA. |
| first_indexed | 2024-12-19T10:25:11Z |
| format | Article |
| id | doaj.art-d5c8dbdb6b2a43429b8bc6b652505324 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-19T10:25:11Z |
| publishDate | 2021-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-d5c8dbdb6b2a43429b8bc6b6525053242022-12-21T20:25:56ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-05-011110.3389/fonc.2021.641931641931DCTPP1, an Oncogene Regulated by miR-378a-3p, Promotes Proliferation of Breast Cancer via DNA Repair Signaling PathwayMing Niu0Ming Shan1Yang Liu2Yanni Song3Ji-guang Han4Shanshan Sun5Xiao-shuan Liang6Guo-qiang Zhang7Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, ChinaDepartment of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, ChinaResearch Institute of Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin, ChinaDepartment of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, ChinaDepartment of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, ChinaDepartment of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, ChinaDepartment of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, ChinaDepartment of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, ChinaBreast cancer (BRCA) is one of the most deadly cancers worldwide, with poor survival rates that could be due to its high proliferation. Human all-alpha dCTP pyrophosphatase 1 (DCTPP1) is implicated in numerous diseases, including cancers. However, its role in BRCA is unclear. In this study, we used bioinformatic analyses of the ONCOMINE, UALCAN, and GEPIA databases to determine the expression pattern of DCTPP1 in BRCA. We found that elevated DCTPP1 levels correlate with poor BRCA prognosis. DCTPP1 silencing inhibited BRCA cell proliferation and induced apoptosis in vitro, as well as in vivo. Our data show that this tumorigenic effect depends on DNA repair signaling. Moreover, we found that DCTPP1 is directly modulated by miR-378a-3p, whose downregulation is linked to BRCA progression. Our results showed down-regulation of miR-378a-3p in BRCA. Upregulation of miR-378a-3p, on the other hand, can inhibit BRCA cell growth and proliferation. This study shows that reduced miR-378a-3p level enhances DCTPP1 expression in BRCA, which promotes proliferation by activating DNA repair signaling in BRCA.https://www.frontiersin.org/articles/10.3389/fonc.2021.641931/fullbreast canceroncogeneDCTPP1miR-378a-3pDNA repair |
| spellingShingle | Ming Niu Ming Shan Yang Liu Yanni Song Ji-guang Han Shanshan Sun Xiao-shuan Liang Guo-qiang Zhang DCTPP1, an Oncogene Regulated by miR-378a-3p, Promotes Proliferation of Breast Cancer via DNA Repair Signaling Pathway Frontiers in Oncology breast cancer oncogene DCTPP1 miR-378a-3p DNA repair |
| title | DCTPP1, an Oncogene Regulated by miR-378a-3p, Promotes Proliferation of Breast Cancer via DNA Repair Signaling Pathway |
| title_full | DCTPP1, an Oncogene Regulated by miR-378a-3p, Promotes Proliferation of Breast Cancer via DNA Repair Signaling Pathway |
| title_fullStr | DCTPP1, an Oncogene Regulated by miR-378a-3p, Promotes Proliferation of Breast Cancer via DNA Repair Signaling Pathway |
| title_full_unstemmed | DCTPP1, an Oncogene Regulated by miR-378a-3p, Promotes Proliferation of Breast Cancer via DNA Repair Signaling Pathway |
| title_short | DCTPP1, an Oncogene Regulated by miR-378a-3p, Promotes Proliferation of Breast Cancer via DNA Repair Signaling Pathway |
| title_sort | dctpp1 an oncogene regulated by mir 378a 3p promotes proliferation of breast cancer via dna repair signaling pathway |
| topic | breast cancer oncogene DCTPP1 miR-378a-3p DNA repair |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.641931/full |
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