Lancifoliaine, a New Bisbenzylisoquinoline from the Bark of Litsea lancifolia

Lancifoliaine, a New Bisbenzylisoquinoline from the Bark of Litsea lancifolia

A new bisbenzylisoquinoline, lancifoliaine (1), together with seven known alkaloids – N-allyllaurolitsine (2), reticuline (3), actinodaphnine, norboldine, pallidine, cassythicine and boldine – were isolated from the stem bark of Litsea lancifolia (Lauraceae). In addition to that of lancifoliaine, co...

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Bibliographic Details
Main Authors: Kazumasa Zaima, Marc Litaudon, Azeana Zahari, Hazrina Hazni, A Hamid A Hadi, Khalijah Awang, Mat Ropi Mukhtar, Syazreen Nadia Sulaiman, Hiroshi Morita
Format: Article
Language:English
Published: MDPI AG 2011-04-01
Series:Molecules
Subjects:
bisbenzylisoquinoline
lancifoliaine
N-allyllaurolitsine
Lauraceae
vaso-relaxant activity
Online Access:http://www.mdpi.com/1420-3049/16/4/3119/
Description
Summary:A new bisbenzylisoquinoline, lancifoliaine (1), together with seven known alkaloids – N-allyllaurolitsine (2), reticuline (3), actinodaphnine, norboldine, pallidine, cassythicine and boldine – were isolated from the stem bark of Litsea lancifolia (Lauraceae). In addition to that of lancifoliaine, complete 13C-NMR data of N-allyl-laurolitsine (2) was also reported. The alkaloidal structures were elucidated by means of high field 1D- and 2D-NMR IR, UV, and LCMS-IT-TOF spectral data. N-Allyllaurolitsine (2) showed a moderate vasorelaxant activity on isolated rat aorta.
ISSN:1420-3049

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