Which Subgroup of First-Episode Schizophrenia Patients Can Remit During the First Year of Antipsychotic Treatment?
ObjectiveTo investigate the persistent remission rate (PRR) and its predictors within the first year of antipsychotic treatment in first-episode schizophrenia (FES) patients.MethodsIn a sample of 301 FES patients who remained in antipsychotic treatment for 1 year, we assessed symptoms with the Posit...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-06-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2020.00566/full |
| _version_ | 1828769651847331840 |
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| author | Zhang Cheng Yanbo Yuan Xue Han Lei Yang Xin Zeng Fude Yang Zheng Lu Chuanyue Wang Hong Deng Jingping Zhao Xin Yu |
| author_facet | Zhang Cheng Yanbo Yuan Xue Han Lei Yang Xin Zeng Fude Yang Zheng Lu Chuanyue Wang Hong Deng Jingping Zhao Xin Yu |
| author_sort | Zhang Cheng |
| collection | DOAJ |
| description | ObjectiveTo investigate the persistent remission rate (PRR) and its predictors within the first year of antipsychotic treatment in first-episode schizophrenia (FES) patients.MethodsIn a sample of 301 FES patients who remained in antipsychotic treatment for 1 year, we assessed symptoms with the Positive and Negative Syndrome Scale (PANSS), cognition in six domains and functioning with the Personal and Social Performance Scale (PSP).ResultsIn total, 75.4% (227/301) of FES patients remaining in antipsychotic treatment reached persistent remission (PR) in one year. The PSP score was higher in remitters than non-remitters at the endpoint of the 1-year follow-up (P <0.0001). The PANSS negative score—but not the PANSS total score, positive score or general psychopathological score; PSP score; or cognitive performance at baseline—was negatively associated with PR. Lower scores for “abstract thinking” and “stereotyped thinking” were independent predictors of PR.ConclusionsIn FES, nearly 3/4 patients could achieve PR with 1 year of antipsychotic treatment, and having fewer negative symptoms, especially thinking and volition symptoms, can predict PR.Clinical Trial Registrationwww.ClinicalTrials.gov, identifier NCT01057849. |
| first_indexed | 2024-12-11T13:51:57Z |
| format | Article |
| id | doaj.art-d5cdc0cc62f949c2b5a11160968ebe2f |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-11T13:51:57Z |
| publishDate | 2020-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-d5cdc0cc62f949c2b5a11160968ebe2f2022-12-22T01:04:14ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402020-06-011110.3389/fpsyt.2020.00566536511Which Subgroup of First-Episode Schizophrenia Patients Can Remit During the First Year of Antipsychotic Treatment?Zhang Cheng0Yanbo Yuan1Xue Han2Lei Yang3Xin Zeng4Fude Yang5Zheng Lu6Chuanyue Wang7Hong Deng8Jingping Zhao9Xin Yu10Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, ChinaPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, ChinaPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, ChinaPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, ChinaPeking University Clinical Research Institute, Beijing, ChinaBeijing Hui-Long-Guan Hospital, Beijing, ChinaTongji Hospital of Tongji University, Shanghai, ChinaBeijing Anding Hospital, Capital Medical University, Beijing, ChinaWest China Hospital, Sichuan University, Chengdu, ChinaMental Health Institute, Second Xiangya Hospital, Central South University, Changsha, ChinaPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, ChinaObjectiveTo investigate the persistent remission rate (PRR) and its predictors within the first year of antipsychotic treatment in first-episode schizophrenia (FES) patients.MethodsIn a sample of 301 FES patients who remained in antipsychotic treatment for 1 year, we assessed symptoms with the Positive and Negative Syndrome Scale (PANSS), cognition in six domains and functioning with the Personal and Social Performance Scale (PSP).ResultsIn total, 75.4% (227/301) of FES patients remaining in antipsychotic treatment reached persistent remission (PR) in one year. The PSP score was higher in remitters than non-remitters at the endpoint of the 1-year follow-up (P <0.0001). The PANSS negative score—but not the PANSS total score, positive score or general psychopathological score; PSP score; or cognitive performance at baseline—was negatively associated with PR. Lower scores for “abstract thinking” and “stereotyped thinking” were independent predictors of PR.ConclusionsIn FES, nearly 3/4 patients could achieve PR with 1 year of antipsychotic treatment, and having fewer negative symptoms, especially thinking and volition symptoms, can predict PR.Clinical Trial Registrationwww.ClinicalTrials.gov, identifier NCT01057849.https://www.frontiersin.org/article/10.3389/fpsyt.2020.00566/fullfirst-episodeschizophreniaantipsychoticremissionnegative symptom |
| spellingShingle | Zhang Cheng Yanbo Yuan Xue Han Lei Yang Xin Zeng Fude Yang Zheng Lu Chuanyue Wang Hong Deng Jingping Zhao Xin Yu Which Subgroup of First-Episode Schizophrenia Patients Can Remit During the First Year of Antipsychotic Treatment? Frontiers in Psychiatry first-episode schizophrenia antipsychotic remission negative symptom |
| title | Which Subgroup of First-Episode Schizophrenia Patients Can Remit During the First Year of Antipsychotic Treatment? |
| title_full | Which Subgroup of First-Episode Schizophrenia Patients Can Remit During the First Year of Antipsychotic Treatment? |
| title_fullStr | Which Subgroup of First-Episode Schizophrenia Patients Can Remit During the First Year of Antipsychotic Treatment? |
| title_full_unstemmed | Which Subgroup of First-Episode Schizophrenia Patients Can Remit During the First Year of Antipsychotic Treatment? |
| title_short | Which Subgroup of First-Episode Schizophrenia Patients Can Remit During the First Year of Antipsychotic Treatment? |
| title_sort | which subgroup of first episode schizophrenia patients can remit during the first year of antipsychotic treatment |
| topic | first-episode schizophrenia antipsychotic remission negative symptom |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2020.00566/full |
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