COVID-19 vaccines: Immune correlates and clinical outcomes
ABSTRACTSevere disease due to COVID-19 has declined dramatically as a result of widespread vaccination and natural immunity in the population. With the emergence of SARS-CoV-2 variants that largely escape vaccine-elicited neutralizing antibody responses, the efficacy of the original vaccines has wan...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2024.2324549 |
| _version_ | 1797248645480841216 |
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| author | Shant H. Mahrokhian Lisa H. Tostanoski Samuel J. Vidal Dan H. Barouch |
| author_facet | Shant H. Mahrokhian Lisa H. Tostanoski Samuel J. Vidal Dan H. Barouch |
| author_sort | Shant H. Mahrokhian |
| collection | DOAJ |
| description | ABSTRACTSevere disease due to COVID-19 has declined dramatically as a result of widespread vaccination and natural immunity in the population. With the emergence of SARS-CoV-2 variants that largely escape vaccine-elicited neutralizing antibody responses, the efficacy of the original vaccines has waned and has required vaccine updating and boosting. Nevertheless, hospitalizations and deaths due to COVID-19 have remained low. In this review, we summarize current knowledge of immune responses that contribute to population immunity and the mechanisms how vaccines attenuate COVID-19 disease severity. |
| first_indexed | 2024-04-24T20:17:53Z |
| format | Article |
| id | doaj.art-d5cddb4db5dc402cb1d85766789d8d24 |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-04-24T20:17:53Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-d5cddb4db5dc402cb1d85766789d8d242024-03-22T13:33:26ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2024-12-0120110.1080/21645515.2024.2324549COVID-19 vaccines: Immune correlates and clinical outcomesShant H. Mahrokhian0Lisa H. Tostanoski1Samuel J. Vidal2Dan H. Barouch3Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USACenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USACenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USACenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USAABSTRACTSevere disease due to COVID-19 has declined dramatically as a result of widespread vaccination and natural immunity in the population. With the emergence of SARS-CoV-2 variants that largely escape vaccine-elicited neutralizing antibody responses, the efficacy of the original vaccines has waned and has required vaccine updating and boosting. Nevertheless, hospitalizations and deaths due to COVID-19 have remained low. In this review, we summarize current knowledge of immune responses that contribute to population immunity and the mechanisms how vaccines attenuate COVID-19 disease severity.https://www.tandfonline.com/doi/10.1080/21645515.2024.2324549COVID-19immune correlatesvaccinesSARS-CoV-2 variantsmucosal immunityT-cells |
| spellingShingle | Shant H. Mahrokhian Lisa H. Tostanoski Samuel J. Vidal Dan H. Barouch COVID-19 vaccines: Immune correlates and clinical outcomes Human Vaccines & Immunotherapeutics COVID-19 immune correlates vaccines SARS-CoV-2 variants mucosal immunity T-cells |
| title | COVID-19 vaccines: Immune correlates and clinical outcomes |
| title_full | COVID-19 vaccines: Immune correlates and clinical outcomes |
| title_fullStr | COVID-19 vaccines: Immune correlates and clinical outcomes |
| title_full_unstemmed | COVID-19 vaccines: Immune correlates and clinical outcomes |
| title_short | COVID-19 vaccines: Immune correlates and clinical outcomes |
| title_sort | covid 19 vaccines immune correlates and clinical outcomes |
| topic | COVID-19 immune correlates vaccines SARS-CoV-2 variants mucosal immunity T-cells |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2024.2324549 |
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