HB-EGF, Transactivation, and Cardiac Hypertrophy
Transactivation of epidermal growth factor receptor (EGFR) family ligands by G protein coupled receptor (GPCR) agonist plays important roles in many physiologic activities. In the heart, heparin-binding EGF-like growth factor (HB-EGF), which is one of the EGF family ligands, is an indispensable mole...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taiwan Society of Geriatric Emergency and Critical Medicine (TSGECM)
2007-03-01
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| Series: | International Journal of Gerontology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1873959808700188 |
| _version_ | 1818131673177391104 |
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| author | Seiji Takashima Masafumi Kitakaze |
| author_facet | Seiji Takashima Masafumi Kitakaze |
| author_sort | Seiji Takashima |
| collection | DOAJ |
| description | Transactivation of epidermal growth factor receptor (EGFR) family ligands by G protein coupled receptor (GPCR) agonist plays important roles in many physiologic activities. In the heart, heparin-binding EGF-like growth factor (HB-EGF), which is one of the EGF family ligands, is an indispensable molecule for cardiac cell metabolism. Membrane-anchored HB-EGF is released by GPCR agonist stimulation and moves signals leading to hypertrophy. Amelioration of this signal transduction by HB-EGF genome deletion causes severe heart dysfunction, indicating the important role of HB-EGF in the heart. Cleavage of HB-EGF was mediated by activation of membrane-anchored metalloprotease. Inhibitor of metalloprotease prevents activation of HB-EGF andattenuates hypertrophic response of cardiomyocytes by GPCR agonists such as angiotensin II or catecholamine. These data strongly suggest that HB-EGF is involved in cardiac development and metabolism. The physiologicand clinical roles of EGF family ligands in the heart are reviewed. |
| first_indexed | 2024-12-11T08:24:40Z |
| format | Article |
| id | doaj.art-d5cf28bc61a4480b9288e9ae89fec2b0 |
| institution | Directory Open Access Journal |
| issn | 1873-9598 |
| language | English |
| last_indexed | 2024-12-11T08:24:40Z |
| publishDate | 2007-03-01 |
| publisher | Taiwan Society of Geriatric Emergency and Critical Medicine (TSGECM) |
| record_format | Article |
| series | International Journal of Gerontology |
| spelling | doaj.art-d5cf28bc61a4480b9288e9ae89fec2b02022-12-22T01:14:34ZengTaiwan Society of Geriatric Emergency and Critical Medicine (TSGECM)International Journal of Gerontology1873-95982007-03-01112910.1016/S1873-9598(08)70018-8HB-EGF, Transactivation, and Cardiac HypertrophySeiji Takashima0Masafumi Kitakaze1Department of Cardiovascular Medicine, Graduate School of Medicine and Health Care Center, Osaka University, Osaka, JapanCardiovascular Division of Medicine, National Cardiovascular Center of Japan, Suita, Osaka, JapanTransactivation of epidermal growth factor receptor (EGFR) family ligands by G protein coupled receptor (GPCR) agonist plays important roles in many physiologic activities. In the heart, heparin-binding EGF-like growth factor (HB-EGF), which is one of the EGF family ligands, is an indispensable molecule for cardiac cell metabolism. Membrane-anchored HB-EGF is released by GPCR agonist stimulation and moves signals leading to hypertrophy. Amelioration of this signal transduction by HB-EGF genome deletion causes severe heart dysfunction, indicating the important role of HB-EGF in the heart. Cleavage of HB-EGF was mediated by activation of membrane-anchored metalloprotease. Inhibitor of metalloprotease prevents activation of HB-EGF andattenuates hypertrophic response of cardiomyocytes by GPCR agonists such as angiotensin II or catecholamine. These data strongly suggest that HB-EGF is involved in cardiac development and metabolism. The physiologicand clinical roles of EGF family ligands in the heart are reviewed.http://www.sciencedirect.com/science/article/pii/S1873959808700188cardiac hypertrophyheart failureHB-EGFmetalloprotease |
| spellingShingle | Seiji Takashima Masafumi Kitakaze HB-EGF, Transactivation, and Cardiac Hypertrophy International Journal of Gerontology cardiac hypertrophy heart failure HB-EGF metalloprotease |
| title | HB-EGF, Transactivation, and Cardiac Hypertrophy |
| title_full | HB-EGF, Transactivation, and Cardiac Hypertrophy |
| title_fullStr | HB-EGF, Transactivation, and Cardiac Hypertrophy |
| title_full_unstemmed | HB-EGF, Transactivation, and Cardiac Hypertrophy |
| title_short | HB-EGF, Transactivation, and Cardiac Hypertrophy |
| title_sort | hb egf transactivation and cardiac hypertrophy |
| topic | cardiac hypertrophy heart failure HB-EGF metalloprotease |
| url | http://www.sciencedirect.com/science/article/pii/S1873959808700188 |
| work_keys_str_mv | AT seijitakashima hbegftransactivationandcardiachypertrophy AT masafumikitakaze hbegftransactivationandcardiachypertrophy |