Producing Integrase Minus Lentivirus for Transient Expression of the Desired Protein and Reduced Side Effects of the Virus in Gene Therapy

Producing Integrase Minus Lentivirus for Transient Expression of the Desired Protein and Reduced Side Effects of the Virus in Gene Therapy

Background: Lentiviral vectors are very efficient tools for gene therapy. But, proviral integration make their use dangerous; therefore, the safer integration deficient lentiviral vectors (IDLVs) can be produced through the use of integrase gene mutations that specifically prevent proviral integrati...

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Bibliographic Details
Main Authors: Laleh Shariati, Zahra Mohammadi, Zahra Hejazi, Mehran Modarres, Mansour Salehi, Mohammad Hossein Modarresi, Hossein Khanahmad
Format: Article
Language:fas
Published: Isfahan University of Medical Sciences 2015-05-01
Series:مجله دانشکده پزشکی اصفهان
Subjects:
Lentivirus packaging
Integrase-minus
Transient expression
Online Access:http://jims.mui.ac.ir/index.php/jims/article/view/4631

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