Characterization of <i>Gfat1</i> (<i>zeppelin</i>) and <i>Gfat2</i>, Essential Paralogous Genes Which Encode the Enzymes That Catalyze the Rate-Limiting Step in the Hexosamine Biosynthetic Pathway in <i>Drosophila melanogaster</i>

Characterization of <i>Gfat1</i> (<i>zeppelin</i>) and <i>Gfat2</i>, Essential Paralogous Genes Which Encode the Enzymes That Catalyze the Rate-Limiting Step in the Hexosamine Biosynthetic Pathway in <i>Drosophila melanogaster</i>

The <i>zeppelin</i> (<i>zep</i>) locus is known for its essential role in the development of the embryonic cuticle of <i>Drosophila melanogaster</i>. We show here that <i>zep</i> encodes <i>Gfat1</i> (<i>Glutamine: Fructose-6-Phosphat...

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Bibliographic Details
Main Authors: Shawn Cotsworth, Catherine J. Jackson, Graham Hallson, Kathleen A. Fitzpatrick, Monika Syrzycka, Alistair B. Coulthard, Amy Bejsovec, Marcella Marchetti, Sergio Pimpinelli, Simon J. H. Wang, Robert G. Camfield, Esther M. Verheyen, Donald A. Sinclair, Barry M. Honda, Arthur J. Hilliker
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Cells
Subjects:
<i>Gfat1</i>
<i>Gfat2</i>
HBP
hexosamine biosynthesis
<i>Drosophila heterochromatin</i>
<i>zeppelin</i>
Online Access:https://www.mdpi.com/2073-4409/11/3/448

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