Musculoskeletal Effects of Altered GH Action
Growth hormone (GH) is a peptide hormone that can signal directly through its receptor or indirectly through insulin-like growth factor 1 (IGF-1) stimulation. GH draws its name from its anabolic effects on muscle and bone but also has distinct metabolic effects in multiple tissues. In addition to it...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-05-01
|
| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.867921/full |
| _version_ | 1817987428776935424 |
|---|---|
| author | Jonathan A. Young Shouan Zhu Shouan Zhu Shouan Zhu Edward O. List Silvana Duran-Ortiz Yosri Slama Darlene E. Berryman Darlene E. Berryman |
| author_facet | Jonathan A. Young Shouan Zhu Shouan Zhu Shouan Zhu Edward O. List Silvana Duran-Ortiz Yosri Slama Darlene E. Berryman Darlene E. Berryman |
| author_sort | Jonathan A. Young |
| collection | DOAJ |
| description | Growth hormone (GH) is a peptide hormone that can signal directly through its receptor or indirectly through insulin-like growth factor 1 (IGF-1) stimulation. GH draws its name from its anabolic effects on muscle and bone but also has distinct metabolic effects in multiple tissues. In addition to its metabolic and musculoskeletal effects, GH is closely associated with aging, with levels declining as individuals age but GH action negatively correlating with lifespan. GH’s effects have been studied in human conditions of GH alteration, such as acromegaly and Laron syndrome, and GH therapies have been suggested to combat aging-related musculoskeletal diseases, in part, because of the decline in GH levels with advanced age. While clinical data are inconclusive, animal models have been indispensable in understanding the underlying molecular mechanisms of GH action. This review will provide a brief overview of the musculoskeletal effects of GH, focusing on clinical and animal models. |
| first_indexed | 2024-04-14T00:22:12Z |
| format | Article |
| id | doaj.art-d5cfafda3df94207836f6cc1d4e677a3 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-14T00:22:12Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-d5cfafda3df94207836f6cc1d4e677a32022-12-22T02:22:55ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-05-011310.3389/fphys.2022.867921867921Musculoskeletal Effects of Altered GH ActionJonathan A. Young0Shouan Zhu1Shouan Zhu2Shouan Zhu3Edward O. List4Silvana Duran-Ortiz5Yosri Slama6Darlene E. Berryman7Darlene E. Berryman8Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, United StatesHeritage College of Osteopathic Medicine, Ohio University, Athens, OH, United StatesOhio Musculoskeletal and Neurological Institute, Heritage College of Osteopathic Medicine, Athens, OH, United StatesDepartment of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, United StatesEdison Biotechnology Institute, Ohio University, Athens, OH, United StatesEdison Biotechnology Institute, Ohio University, Athens, OH, United StatesEdison Biotechnology Institute, Ohio University, Athens, OH, United StatesDepartment of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, United StatesEdison Biotechnology Institute, Ohio University, Athens, OH, United StatesGrowth hormone (GH) is a peptide hormone that can signal directly through its receptor or indirectly through insulin-like growth factor 1 (IGF-1) stimulation. GH draws its name from its anabolic effects on muscle and bone but also has distinct metabolic effects in multiple tissues. In addition to its metabolic and musculoskeletal effects, GH is closely associated with aging, with levels declining as individuals age but GH action negatively correlating with lifespan. GH’s effects have been studied in human conditions of GH alteration, such as acromegaly and Laron syndrome, and GH therapies have been suggested to combat aging-related musculoskeletal diseases, in part, because of the decline in GH levels with advanced age. While clinical data are inconclusive, animal models have been indispensable in understanding the underlying molecular mechanisms of GH action. This review will provide a brief overview of the musculoskeletal effects of GH, focusing on clinical and animal models.https://www.frontiersin.org/articles/10.3389/fphys.2022.867921/fullsomatopauseosteoarthritissarcopeniagrowth hormoneacromegalygrowth hormone deficiency (GHD) |
| spellingShingle | Jonathan A. Young Shouan Zhu Shouan Zhu Shouan Zhu Edward O. List Silvana Duran-Ortiz Yosri Slama Darlene E. Berryman Darlene E. Berryman Musculoskeletal Effects of Altered GH Action Frontiers in Physiology somatopause osteoarthritis sarcopenia growth hormone acromegaly growth hormone deficiency (GHD) |
| title | Musculoskeletal Effects of Altered GH Action |
| title_full | Musculoskeletal Effects of Altered GH Action |
| title_fullStr | Musculoskeletal Effects of Altered GH Action |
| title_full_unstemmed | Musculoskeletal Effects of Altered GH Action |
| title_short | Musculoskeletal Effects of Altered GH Action |
| title_sort | musculoskeletal effects of altered gh action |
| topic | somatopause osteoarthritis sarcopenia growth hormone acromegaly growth hormone deficiency (GHD) |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2022.867921/full |
| work_keys_str_mv | AT jonathanayoung musculoskeletaleffectsofalteredghaction AT shouanzhu musculoskeletaleffectsofalteredghaction AT shouanzhu musculoskeletaleffectsofalteredghaction AT shouanzhu musculoskeletaleffectsofalteredghaction AT edwardolist musculoskeletaleffectsofalteredghaction AT silvanaduranortiz musculoskeletaleffectsofalteredghaction AT yosrislama musculoskeletaleffectsofalteredghaction AT darleneeberryman musculoskeletaleffectsofalteredghaction AT darleneeberryman musculoskeletaleffectsofalteredghaction |