Multi-targeting of K-Ras domains and mutations by peptide and small molecule inhibitors.

K-Ras activating mutations are significantly associated with tumor progression and aggressive metastatic behavior in various human cancers including pancreatic cancer. So far, despite a large number of concerted efforts, targeting of mutant-type K-Ras has not been successful. In this regard, we aime...

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Bibliographic Details
Main Authors:	Mansour Poorebrahim, Mohammad Foad Abazari, Leila Moradi, Behzad Shahbazi, Reza Mahmoudi, Hourieh Kalhor, Hassan Askari, Ladan Teimoori-Toolabi
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2022-04-01
Series:	PLoS Computational Biology
Online Access:	https://doi.org/10.1371/journal.pcbi.1009962

Multi-targeting of K-Ras domains and mutations by peptide and small molecule inhibitors by Mansour Poorebrahim, Mohammad Foad Abazari, Leila Moradi, Behzad Shahbazi, Reza Mahmoudi, Hourieh Kalhor, Hassan Askari, Ladan Teimoori-Toolabi

Published 2022-04-01

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Multi-targeting of K-Ras domains and mutations by peptide and small molecule inhibitors.

Multi-targeting of K-Ras domains and mutations by peptide and small molecule inhibitors by Mansour Poorebrahim, Mohammad Foad Abazari, Leila Moradi, Behzad Shahbazi, Reza Mahmoudi, Hourieh Kalhor, Hassan Askari, Ladan Teimoori-Toolabi

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