Tribbles homolog 2 (Trib2), a pseudo serine/threonine kinase in tumorigenesis and stem cell fate decisions
Abstract The family of Tribbles proteins play many critical nonenzymatic roles and regulate a wide range of key signaling pathways. Tribbles homolog 2 (Trib2) is a pseudo serine/threonine kinase that functions as a scaffold or adaptor in various physiological and pathological processes. Trib2 can in...
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| Format: | Article |
| Language: | English |
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BMC
2021-04-01
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| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12964-021-00725-y |
| _version_ | 1818623669885206528 |
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| author | Yu Fang Angelina Olegovna Zekiy Farhoodeh Ghaedrahmati Anton Timoshin Maryam Farzaneh Amir Anbiyaiee Seyed Esmaeil Khoshnam |
| author_facet | Yu Fang Angelina Olegovna Zekiy Farhoodeh Ghaedrahmati Anton Timoshin Maryam Farzaneh Amir Anbiyaiee Seyed Esmaeil Khoshnam |
| author_sort | Yu Fang |
| collection | DOAJ |
| description | Abstract The family of Tribbles proteins play many critical nonenzymatic roles and regulate a wide range of key signaling pathways. Tribbles homolog 2 (Trib2) is a pseudo serine/threonine kinase that functions as a scaffold or adaptor in various physiological and pathological processes. Trib2 can interact with E3 ubiquitin ligases and control protein stability of downstream effectors. This protein is induced by mitogens and enhances the propagation of several cancer cells, including myeloid leukemia, liver, lung, skin, bone, brain, and pancreatic. Thus, Trib2 can be a predictive and valuable biomarker for the diagnosis and treatment of cancer. Recent studies have illustrated that Trib2 plays a major role in cell fate determination of stem cells. Stem cells have the capacity to self-renew and differentiate into specific cell types. Stem cells are important sources for cell-based regenerative medicine and drug screening. Trib2 has been found to increase the self-renewal ability of embryonic stem cells, the reprogramming efficiency of somatic cells, and chondrogenesis. In this review, we will focus on the recent advances of Trib2 function in tumorigenesis and stem cell fate decisions. Video abstract |
| first_indexed | 2024-12-16T18:44:45Z |
| format | Article |
| id | doaj.art-d5d0fe8efbe04336a3ff44c9af21758e |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-12-16T18:44:45Z |
| publishDate | 2021-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-d5d0fe8efbe04336a3ff44c9af21758e2022-12-21T22:20:53ZengBMCCell Communication and Signaling1478-811X2021-04-011911810.1186/s12964-021-00725-yTribbles homolog 2 (Trib2), a pseudo serine/threonine kinase in tumorigenesis and stem cell fate decisionsYu Fang0Angelina Olegovna Zekiy1Farhoodeh Ghaedrahmati2Anton Timoshin3Maryam Farzaneh4Amir Anbiyaiee5Seyed Esmaeil Khoshnam6Anyang Center for Chemical and Pharmaceutical Engineering, College of Chemistry and Chemical Engineering, Anyang Normal UniversityDepartment of Prosthetic Dentistry, Sechenov First Moscow State Medical UniversityDepartment of Immunology, School of Medicine, Isfahan University of Medical SciencesIndependent researcherFertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical SciencesDepartment of Surgery, School of Medicine, Ahvaz Jundishapur University of Medical SciencesPersian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical SciencesAbstract The family of Tribbles proteins play many critical nonenzymatic roles and regulate a wide range of key signaling pathways. Tribbles homolog 2 (Trib2) is a pseudo serine/threonine kinase that functions as a scaffold or adaptor in various physiological and pathological processes. Trib2 can interact with E3 ubiquitin ligases and control protein stability of downstream effectors. This protein is induced by mitogens and enhances the propagation of several cancer cells, including myeloid leukemia, liver, lung, skin, bone, brain, and pancreatic. Thus, Trib2 can be a predictive and valuable biomarker for the diagnosis and treatment of cancer. Recent studies have illustrated that Trib2 plays a major role in cell fate determination of stem cells. Stem cells have the capacity to self-renew and differentiate into specific cell types. Stem cells are important sources for cell-based regenerative medicine and drug screening. Trib2 has been found to increase the self-renewal ability of embryonic stem cells, the reprogramming efficiency of somatic cells, and chondrogenesis. In this review, we will focus on the recent advances of Trib2 function in tumorigenesis and stem cell fate decisions. Video abstracthttps://doi.org/10.1186/s12964-021-00725-yPluripotent stem cellsTribbles homolog 2TumorigenesisPluripotencyReprogrammingStem cell fate |
| spellingShingle | Yu Fang Angelina Olegovna Zekiy Farhoodeh Ghaedrahmati Anton Timoshin Maryam Farzaneh Amir Anbiyaiee Seyed Esmaeil Khoshnam Tribbles homolog 2 (Trib2), a pseudo serine/threonine kinase in tumorigenesis and stem cell fate decisions Cell Communication and Signaling Pluripotent stem cells Tribbles homolog 2 Tumorigenesis Pluripotency Reprogramming Stem cell fate |
| title | Tribbles homolog 2 (Trib2), a pseudo serine/threonine kinase in tumorigenesis and stem cell fate decisions |
| title_full | Tribbles homolog 2 (Trib2), a pseudo serine/threonine kinase in tumorigenesis and stem cell fate decisions |
| title_fullStr | Tribbles homolog 2 (Trib2), a pseudo serine/threonine kinase in tumorigenesis and stem cell fate decisions |
| title_full_unstemmed | Tribbles homolog 2 (Trib2), a pseudo serine/threonine kinase in tumorigenesis and stem cell fate decisions |
| title_short | Tribbles homolog 2 (Trib2), a pseudo serine/threonine kinase in tumorigenesis and stem cell fate decisions |
| title_sort | tribbles homolog 2 trib2 a pseudo serine threonine kinase in tumorigenesis and stem cell fate decisions |
| topic | Pluripotent stem cells Tribbles homolog 2 Tumorigenesis Pluripotency Reprogramming Stem cell fate |
| url | https://doi.org/10.1186/s12964-021-00725-y |
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