Modulation of Gene Expression in a Sterile Atopic Dermatitis Model and Inhibition of <i>Staphylococcus aureus</i> Adhesion by Fucoidan
Atopic dermatitis is a multifactorial pathology that includes perturbations of gene expression and increased adhesion of <i>Staphylococcus aureus.</i> Fucoidans are seaweed-derived sulfated fucose-rich polysaccharides that are known to be anti-inflammatory and may inhibit adhesion of pat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Dermatopathology |
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| Online Access: | https://www.mdpi.com/2296-3529/8/2/12 |
| _version_ | 1797540054053158912 |
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| author | Ah Young Park Maureen Bourtembourg Aline Chrétien Roland Hubaux Céline Lancelot Michel Salmon J. Helen Fitton |
| author_facet | Ah Young Park Maureen Bourtembourg Aline Chrétien Roland Hubaux Céline Lancelot Michel Salmon J. Helen Fitton |
| author_sort | Ah Young Park |
| collection | DOAJ |
| description | Atopic dermatitis is a multifactorial pathology that includes perturbations of gene expression and increased adhesion of <i>Staphylococcus aureus.</i> Fucoidans are seaweed-derived sulfated fucose-rich polysaccharides that are known to be anti-inflammatory and may inhibit adhesion of pathogens. Fucoidan was assessed for effects on gene expression of an in vitro 3D model of atopic dermatitis. It was also assessed for inhibitory effects on the adhesion of bacteria onto 3D reconstructed skin. Fucoidan significantly altered gene expression in the atopic dermatitis model, and there was a trend to reduce periostin levels. Fucoidan significantly inhibited the adhesion of <i>Staphylococcus aureus</i> and <i>Cutibacterium acnes</i> but did not affect the adhesion of <i>Staphylococcus epidermidis</i>. Fucoidan may be a useful topical agent to assist in the management of atopic dermatitis. |
| first_indexed | 2024-03-10T12:54:38Z |
| format | Article |
| id | doaj.art-d5d1814ddcc0479b8014041c4cf788fc |
| institution | Directory Open Access Journal |
| issn | 2296-3529 |
| language | English |
| last_indexed | 2024-03-10T12:54:38Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Dermatopathology |
| spelling | doaj.art-d5d1814ddcc0479b8014041c4cf788fc2023-11-21T12:03:59ZengMDPI AGDermatopathology2296-35292021-03-0182698310.3390/dermatopathology8020012Modulation of Gene Expression in a Sterile Atopic Dermatitis Model and Inhibition of <i>Staphylococcus aureus</i> Adhesion by FucoidanAh Young Park0Maureen Bourtembourg1Aline Chrétien2Roland Hubaux3Céline Lancelot4Michel Salmon5J. Helen Fitton6Marinova Pty Ltd., 249 Kennedy Drive, Cambridge, TAS 7170, AustraliaStratiCELL, Crealys Science Park, Rue Jean Sonet 10, B-5032 Isnes, BelgiumStratiCELL, Crealys Science Park, Rue Jean Sonet 10, B-5032 Isnes, BelgiumStratiCELL, Crealys Science Park, Rue Jean Sonet 10, B-5032 Isnes, BelgiumStratiCELL, Crealys Science Park, Rue Jean Sonet 10, B-5032 Isnes, BelgiumStratiCELL, Crealys Science Park, Rue Jean Sonet 10, B-5032 Isnes, BelgiumMarinova Pty Ltd., 249 Kennedy Drive, Cambridge, TAS 7170, AustraliaAtopic dermatitis is a multifactorial pathology that includes perturbations of gene expression and increased adhesion of <i>Staphylococcus aureus.</i> Fucoidans are seaweed-derived sulfated fucose-rich polysaccharides that are known to be anti-inflammatory and may inhibit adhesion of pathogens. Fucoidan was assessed for effects on gene expression of an in vitro 3D model of atopic dermatitis. It was also assessed for inhibitory effects on the adhesion of bacteria onto 3D reconstructed skin. Fucoidan significantly altered gene expression in the atopic dermatitis model, and there was a trend to reduce periostin levels. Fucoidan significantly inhibited the adhesion of <i>Staphylococcus aureus</i> and <i>Cutibacterium acnes</i> but did not affect the adhesion of <i>Staphylococcus epidermidis</i>. Fucoidan may be a useful topical agent to assist in the management of atopic dermatitis.https://www.mdpi.com/2296-3529/8/2/12atopic dermatitis<i>Staphylococcus aureus</i>fucoidanperiostinreconstructed human epidermis |
| spellingShingle | Ah Young Park Maureen Bourtembourg Aline Chrétien Roland Hubaux Céline Lancelot Michel Salmon J. Helen Fitton Modulation of Gene Expression in a Sterile Atopic Dermatitis Model and Inhibition of <i>Staphylococcus aureus</i> Adhesion by Fucoidan Dermatopathology atopic dermatitis <i>Staphylococcus aureus</i> fucoidan periostin reconstructed human epidermis |
| title | Modulation of Gene Expression in a Sterile Atopic Dermatitis Model and Inhibition of <i>Staphylococcus aureus</i> Adhesion by Fucoidan |
| title_full | Modulation of Gene Expression in a Sterile Atopic Dermatitis Model and Inhibition of <i>Staphylococcus aureus</i> Adhesion by Fucoidan |
| title_fullStr | Modulation of Gene Expression in a Sterile Atopic Dermatitis Model and Inhibition of <i>Staphylococcus aureus</i> Adhesion by Fucoidan |
| title_full_unstemmed | Modulation of Gene Expression in a Sterile Atopic Dermatitis Model and Inhibition of <i>Staphylococcus aureus</i> Adhesion by Fucoidan |
| title_short | Modulation of Gene Expression in a Sterile Atopic Dermatitis Model and Inhibition of <i>Staphylococcus aureus</i> Adhesion by Fucoidan |
| title_sort | modulation of gene expression in a sterile atopic dermatitis model and inhibition of i staphylococcus aureus i adhesion by fucoidan |
| topic | atopic dermatitis <i>Staphylococcus aureus</i> fucoidan periostin reconstructed human epidermis |
| url | https://www.mdpi.com/2296-3529/8/2/12 |
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