Optimal number of endoscopic biopsies for diagnosis of early gastric cancer
Background and study aims No recommendations are available for optimal number of endoscopic biopsies for early gastric cancer (GC), and whether detection of early GC is improved by increasing the number of biopsy is unclear. We therefore evaluated the relationship between number of biopsies and diag...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Georg Thieme Verlag KG
2019-12-01
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| Series: | Endoscopy International Open |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/a-1007-1730 |
| _version_ | 1818958966215933952 |
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| author | Masaki Nishitani Naohiro Yoshida Shigetsugu Tsuji Teppei Masunaga Hirokazu Hirai Saori Miyajima Akihiro Dejima Takashi Nakashima Shigenori Wakita Kenichi Takemura Hiroshi Minato Shuichi Kaneko Hisashi Doyama |
| author_facet | Masaki Nishitani Naohiro Yoshida Shigetsugu Tsuji Teppei Masunaga Hirokazu Hirai Saori Miyajima Akihiro Dejima Takashi Nakashima Shigenori Wakita Kenichi Takemura Hiroshi Minato Shuichi Kaneko Hisashi Doyama |
| author_sort | Masaki Nishitani |
| collection | DOAJ |
| description | Background and study aims No recommendations are available for optimal number of endoscopic biopsies for early gastric cancer (GC), and whether detection of early GC is improved by increasing the number of biopsy is unclear. We therefore evaluated the relationship between number of biopsies and diagnostic accuracy.
Materials and methods We retrospectively evaluated 858 early GCs (623 from endoscopic submucosal dissection and 235 surgical specimens), which we classified as obtained after one, two, or three or more biopsies. We assessed diagnostic accuracy by number of biopsies, and in subgroups by tumor diameter, gross type, and surface color.
Results Almost half the lesions were obtained after one biopsy each, 30 % after two biopsies, and 20 % after three or more biopsies. Although diagnostic accuracy increased with biopsy number, it was significantly greater for the two-biopsy group than the one-biopsy group, (92.5 % vs. 83.9 %, P = 0.0009), but did not significantly differ between the two- and three or more-biopsy groups. This finding was seen when tumors were evaluated by size, but not by elevated type and surface color, for which more biopsies did not improve diagnostic accuracy. Multivariate analysis demonstrated that two or more biopsies was the independent significant factors for diagnostic accuracy.
Conclusions Two biopsies are the optimal number required to diagnose early GC. |
| first_indexed | 2024-12-20T11:34:08Z |
| format | Article |
| id | doaj.art-d5d383674200401cbcd745100f5dad30 |
| institution | Directory Open Access Journal |
| issn | 2364-3722 2196-9736 |
| language | English |
| last_indexed | 2024-12-20T11:34:08Z |
| publishDate | 2019-12-01 |
| publisher | Georg Thieme Verlag KG |
| record_format | Article |
| series | Endoscopy International Open |
| spelling | doaj.art-d5d383674200401cbcd745100f5dad302022-12-21T19:42:10ZengGeorg Thieme Verlag KGEndoscopy International Open2364-37222196-97362019-12-010712E1683E169010.1055/a-1007-1730Optimal number of endoscopic biopsies for diagnosis of early gastric cancerMasaki Nishitani0Naohiro Yoshida1Shigetsugu Tsuji2Teppei Masunaga3Hirokazu Hirai4Saori Miyajima5Akihiro Dejima6Takashi Nakashima7Shigenori Wakita8Kenichi Takemura9Hiroshi Minato10Shuichi Kaneko11Hisashi Doyama12Department of Gastroenterology, Ishikawa Prefectural Central Hospital, Kanazawa, JapanDepartment of Gastroenterology, Ishikawa Prefectural Central Hospital, Kanazawa, JapanDepartment of Gastroenterology, Ishikawa Prefectural Central Hospital, Kanazawa, JapanDepartment of Gastroenterology, Ishikawa Prefectural Central Hospital, Kanazawa, JapanDepartment of Gastroenterology, Ishikawa Prefectural Central Hospital, Kanazawa, JapanDepartment of Gastroenterology, Ishikawa Prefectural Central Hospital, Kanazawa, JapanDepartment of Gastroenterology, Ishikawa Prefectural Central Hospital, Kanazawa, JapanDepartment of Gastroenterology, Ishikawa Prefectural Central Hospital, Kanazawa, JapanDepartment of Gastroenterology, Ishikawa Prefectural Central Hospital, Kanazawa, JapanDepartment of Gastroenterology, Ishikawa Prefectural Central Hospital, Kanazawa, JapanDepartment of Diagnostic Pathology, Ishikawa Prefectural Central Hospital, Kanazawa, JapanDepartment of Gastroenterology, Kanazawa University Hospital, Kanazawa, JapanDepartment of Gastroenterology, Ishikawa Prefectural Central Hospital, Kanazawa, JapanBackground and study aims No recommendations are available for optimal number of endoscopic biopsies for early gastric cancer (GC), and whether detection of early GC is improved by increasing the number of biopsy is unclear. We therefore evaluated the relationship between number of biopsies and diagnostic accuracy. Materials and methods We retrospectively evaluated 858 early GCs (623 from endoscopic submucosal dissection and 235 surgical specimens), which we classified as obtained after one, two, or three or more biopsies. We assessed diagnostic accuracy by number of biopsies, and in subgroups by tumor diameter, gross type, and surface color. Results Almost half the lesions were obtained after one biopsy each, 30 % after two biopsies, and 20 % after three or more biopsies. Although diagnostic accuracy increased with biopsy number, it was significantly greater for the two-biopsy group than the one-biopsy group, (92.5 % vs. 83.9 %, P = 0.0009), but did not significantly differ between the two- and three or more-biopsy groups. This finding was seen when tumors were evaluated by size, but not by elevated type and surface color, for which more biopsies did not improve diagnostic accuracy. Multivariate analysis demonstrated that two or more biopsies was the independent significant factors for diagnostic accuracy. Conclusions Two biopsies are the optimal number required to diagnose early GC.http://www.thieme-connect.de/DOI/DOI?10.1055/a-1007-1730 |
| spellingShingle | Masaki Nishitani Naohiro Yoshida Shigetsugu Tsuji Teppei Masunaga Hirokazu Hirai Saori Miyajima Akihiro Dejima Takashi Nakashima Shigenori Wakita Kenichi Takemura Hiroshi Minato Shuichi Kaneko Hisashi Doyama Optimal number of endoscopic biopsies for diagnosis of early gastric cancer Endoscopy International Open |
| title | Optimal number of endoscopic biopsies for diagnosis of early gastric cancer |
| title_full | Optimal number of endoscopic biopsies for diagnosis of early gastric cancer |
| title_fullStr | Optimal number of endoscopic biopsies for diagnosis of early gastric cancer |
| title_full_unstemmed | Optimal number of endoscopic biopsies for diagnosis of early gastric cancer |
| title_short | Optimal number of endoscopic biopsies for diagnosis of early gastric cancer |
| title_sort | optimal number of endoscopic biopsies for diagnosis of early gastric cancer |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/a-1007-1730 |
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