The effect of oxidative stress related with ischemia-reperfusion damage on the pathogenesis of atrial fibrillation developing after coronary artery bypass graft surgery
Objectives: We aimed to investigate the role of oxidative stress related with ischemia- reperfusion damage on the pathogenesis of atrial fibrillation (AF) developing after coronary artery bypass graft (CABG) surgery. Study design: In our prospective, single-center study, 118 patients who underwent...
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| Format: | Article |
| Language: | English |
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KARE Publishing
2014-07-01
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| Series: | Türk Kardiyoloji Derneği Arşivi |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-84032 |
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| author | Veysel Oktay Onur Baydar Umit Yasar Sinan Cuneyt Kocas Okay Abaci Ahmet Yildiz Zerrin Yigit Cenk Eray Yildiz Alican Hatemi Gurkan Cetin Aysem Kaya |
| author_facet | Veysel Oktay Onur Baydar Umit Yasar Sinan Cuneyt Kocas Okay Abaci Ahmet Yildiz Zerrin Yigit Cenk Eray Yildiz Alican Hatemi Gurkan Cetin Aysem Kaya |
| author_sort | Veysel Oktay |
| collection | DOAJ |
| description | Objectives: We aimed to investigate the role of oxidative stress related with ischemia- reperfusion damage on the pathogenesis of atrial fibrillation (AF) developing after coronary artery bypass graft (CABG) surgery.
Study design: In our prospective, single-center study, 118 patients who underwent elective isolated on-pump CABG surgery were included. Patients were divided into two groups according to the development of postoperative atrial fibrillation (POAF) as Group 1: Patients who developed POAF, and Group 2: Patients who remained in sinus rhythm. In addition to preoperative demographic, laboratory, echocardiographic, intraoperative, and postoperative clinical characteristics, levels of plasma total oxidative status (TOS) after placement and removal of aortic cross clamp (ACC) were compared between the two groups. Predictors of POAF were also investigated by multivariate logistic regression analysis.
Results: A comparison of preoperative demographic, laboratory, echocardiographic, and postoperative clinical characteristics between the two groups showed that patients in Group 1 were significantly older (65.6+-7.20 vs. 59.6+-9.07, p<0.001), had a lower hematocrit level (37.5+-5.16 vs. 39.7+-5.28; p=0.034), and an enlarged left atrium diameter (39+-0.45 vs. 3.6+-0.48; p=0.006). Changes in plasma TOS levels after placement and removal of ACC were statistically significant in Group 1 [13 (8.6- 23), 30 (18.1-47.3); p=0.001 vs. 14 (8.8-22.2), 24 (21.4-42.7); p=0.060]. Length of stay in the intensive care unit [3 (2-14) vs. 2 (1-58); p=0.001] and length of stay in hospital [7 (6-85) vs. 7 (5-58); p=0.001] were prolonged in Group 1. In multivariate logistic regression analysis, aging (odds ratio (OR): 1.088, 95% confidence interval (CI): 1.005-1.177; p=0.036), hematocrit level (OR: 0.718, 95% CI: 0.538-0.958; p=0.025), pump temperature (OR: 1.445, 95% CI: 1.059-1.972; p=0.020), and plasma TOS level (OR: 1.040, 95% CI: 1.020-1.050; p=0.040) were found to be independent predictors of POAF.
Conclusion: Ischemia-reperfusion damage related with ACC placement may be an important factor on the pathogenesis of POAF. Minimizing the oxidative stress occurring intraoperatively should be targeted for preventing mortality and morbidity due to POAF |
| first_indexed | 2024-04-10T14:31:02Z |
| format | Article |
| id | doaj.art-d5d52453e1b441b7b292ea4b548268a6 |
| institution | Directory Open Access Journal |
| issn | 1016-5169 |
| language | English |
| last_indexed | 2024-04-10T14:31:02Z |
| publishDate | 2014-07-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | Türk Kardiyoloji Derneği Arşivi |
| spelling | doaj.art-d5d52453e1b441b7b292ea4b548268a62023-02-15T16:08:49ZengKARE PublishingTürk Kardiyoloji Derneği Arşivi1016-51692014-07-0142541942510.5543/tkda.2014.84032TKDA-84032The effect of oxidative stress related with ischemia-reperfusion damage on the pathogenesis of atrial fibrillation developing after coronary artery bypass graft surgeryVeysel Oktay0Onur Baydar1Umit Yasar Sinan2Cuneyt Kocas3Okay Abaci4Ahmet Yildiz5Zerrin Yigit6Cenk Eray Yildiz7Alican Hatemi8Gurkan Cetin9Aysem Kaya10Department of Cardiology, Cardiology Institute, İstanbul University, İstanbulDepartment of Cardiology, Cardiology Institute, İstanbul University, İstanbulDepartment of Cardiology, Cardiology Institute, İstanbul University, İstanbulDepartment of Cardiology, Cardiology Institute, İstanbul University, İstanbulDepartment of Cardiology, Cardiology Institute, İstanbul University, İstanbulDepartment of Cardiology, Cardiology Institute, İstanbul University, İstanbulDepartment of Cardiology, Cardiology Institute, İstanbul University, İstanbulDepartment of Cardiovascular Surgery, İstanbul University, Institute of Cardiology, İstanbulDepartment of Cardiovascular Surgery, İstanbul University, Institute of Cardiology, İstanbulDepartment of Cardiovascular Surgery, İstanbul University, Institute of Cardiology, İstanbulDepartment of Biochemistry, Istanbul University, Institute of Cardiology, IstanbulObjectives: We aimed to investigate the role of oxidative stress related with ischemia- reperfusion damage on the pathogenesis of atrial fibrillation (AF) developing after coronary artery bypass graft (CABG) surgery. Study design: In our prospective, single-center study, 118 patients who underwent elective isolated on-pump CABG surgery were included. Patients were divided into two groups according to the development of postoperative atrial fibrillation (POAF) as Group 1: Patients who developed POAF, and Group 2: Patients who remained in sinus rhythm. In addition to preoperative demographic, laboratory, echocardiographic, intraoperative, and postoperative clinical characteristics, levels of plasma total oxidative status (TOS) after placement and removal of aortic cross clamp (ACC) were compared between the two groups. Predictors of POAF were also investigated by multivariate logistic regression analysis. Results: A comparison of preoperative demographic, laboratory, echocardiographic, and postoperative clinical characteristics between the two groups showed that patients in Group 1 were significantly older (65.6+-7.20 vs. 59.6+-9.07, p<0.001), had a lower hematocrit level (37.5+-5.16 vs. 39.7+-5.28; p=0.034), and an enlarged left atrium diameter (39+-0.45 vs. 3.6+-0.48; p=0.006). Changes in plasma TOS levels after placement and removal of ACC were statistically significant in Group 1 [13 (8.6- 23), 30 (18.1-47.3); p=0.001 vs. 14 (8.8-22.2), 24 (21.4-42.7); p=0.060]. Length of stay in the intensive care unit [3 (2-14) vs. 2 (1-58); p=0.001] and length of stay in hospital [7 (6-85) vs. 7 (5-58); p=0.001] were prolonged in Group 1. In multivariate logistic regression analysis, aging (odds ratio (OR): 1.088, 95% confidence interval (CI): 1.005-1.177; p=0.036), hematocrit level (OR: 0.718, 95% CI: 0.538-0.958; p=0.025), pump temperature (OR: 1.445, 95% CI: 1.059-1.972; p=0.020), and plasma TOS level (OR: 1.040, 95% CI: 1.020-1.050; p=0.040) were found to be independent predictors of POAF. Conclusion: Ischemia-reperfusion damage related with ACC placement may be an important factor on the pathogenesis of POAF. Minimizing the oxidative stress occurring intraoperatively should be targeted for preventing mortality and morbidity due to POAFhttps://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-84032atrial fibrillation/etiology/prevention & controlcoronary artery bypass; coronary artery disease/surgery; oxidative stress. |
| spellingShingle | Veysel Oktay Onur Baydar Umit Yasar Sinan Cuneyt Kocas Okay Abaci Ahmet Yildiz Zerrin Yigit Cenk Eray Yildiz Alican Hatemi Gurkan Cetin Aysem Kaya The effect of oxidative stress related with ischemia-reperfusion damage on the pathogenesis of atrial fibrillation developing after coronary artery bypass graft surgery Türk Kardiyoloji Derneği Arşivi atrial fibrillation/etiology/prevention & control coronary artery bypass; coronary artery disease/surgery; oxidative stress. |
| title | The effect of oxidative stress related with ischemia-reperfusion damage on the pathogenesis of atrial fibrillation developing after coronary artery bypass graft surgery |
| title_full | The effect of oxidative stress related with ischemia-reperfusion damage on the pathogenesis of atrial fibrillation developing after coronary artery bypass graft surgery |
| title_fullStr | The effect of oxidative stress related with ischemia-reperfusion damage on the pathogenesis of atrial fibrillation developing after coronary artery bypass graft surgery |
| title_full_unstemmed | The effect of oxidative stress related with ischemia-reperfusion damage on the pathogenesis of atrial fibrillation developing after coronary artery bypass graft surgery |
| title_short | The effect of oxidative stress related with ischemia-reperfusion damage on the pathogenesis of atrial fibrillation developing after coronary artery bypass graft surgery |
| title_sort | effect of oxidative stress related with ischemia reperfusion damage on the pathogenesis of atrial fibrillation developing after coronary artery bypass graft surgery |
| topic | atrial fibrillation/etiology/prevention & control coronary artery bypass; coronary artery disease/surgery; oxidative stress. |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-84032 |
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