The association of statin therapy and cancer: a meta-analysis
Abstract Background Statins are routinely prescribed to lower cholesterol and have been demonstrated to have significant benefits in atherosclerotic cardiovascular disease. However, whether statin therapy has effects on cancer risk remains controversial. In this study, we investigated the influence...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12944-023-01955-4 |
| _version_ | 1797630060196265984 |
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| author | Zijian Chen Panyun Wu Jiangang Wang Pengfei Chen Zhenfei Fang Fei Luo |
| author_facet | Zijian Chen Panyun Wu Jiangang Wang Pengfei Chen Zhenfei Fang Fei Luo |
| author_sort | Zijian Chen |
| collection | DOAJ |
| description | Abstract Background Statins are routinely prescribed to lower cholesterol and have been demonstrated to have significant benefits in atherosclerotic cardiovascular disease. However, whether statin therapy has effects on cancer risk remains controversial. In this study, we investigated the influence of statin therapy on cancer incidence and mortality by conducting a comprehensive meta-analysis of randomized controlled trials. Methods Systematic searches by Cochrane, Embase, Medline, and PubMed were performed to locate data from eligible randomized controlled trials related to statin therapy and oncology. Our main endpoints were cancer incidence and mortality. Fixed-effects models were used in this study. Results This meta-analysis comprised thirty-five randomized controlled studies. Twenty-eight included studies reported cancer incidence, and eighteen reported cancer mortality. The pooled results indicated no reduction in cancer incidence with statins compared to placebo [OR = 0.99, 95% CI (0.95, 1.03)]. In addition, statins did not decrease cancer mortality [OR = 0.99, 95% CI (0.91, 1.07)]. This study also performed a number of subgroup analyses, which showed no effect of statins on cancer subtypes such as genitourinary and breast cancer. Neither the type of statin nor long-term treatment with statins had an effect on cancer incidence and mortality. Conclusion Through comprehensive analysis, we found that statin therapy does not reduce cancer incidence or mortality while protecting the cardiovascular system. Trial registration Prospero CRD42022377871. |
| first_indexed | 2024-03-11T11:01:35Z |
| format | Article |
| id | doaj.art-d5d59a87ba8c4985b2170f4f66598b52 |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-03-11T11:01:35Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-d5d59a87ba8c4985b2170f4f66598b522023-11-12T12:28:45ZengBMCLipids in Health and Disease1476-511X2023-11-0122111310.1186/s12944-023-01955-4The association of statin therapy and cancer: a meta-analysisZijian Chen0Panyun Wu1Jiangang Wang2Pengfei Chen3Zhenfei Fang4Fei Luo5Research Institute of Blood Lipid and Atherosclerosis, the Second Xiangya Hospital, Central South UniversityResearch Institute of Blood Lipid and Atherosclerosis, the Second Xiangya Hospital, Central South UniversityDepartment of Health Management, Central South UniversityResearch Institute of Blood Lipid and Atherosclerosis, the Second Xiangya Hospital, Central South UniversityResearch Institute of Blood Lipid and Atherosclerosis, the Second Xiangya Hospital, Central South UniversityResearch Institute of Blood Lipid and Atherosclerosis, the Second Xiangya Hospital, Central South UniversityAbstract Background Statins are routinely prescribed to lower cholesterol and have been demonstrated to have significant benefits in atherosclerotic cardiovascular disease. However, whether statin therapy has effects on cancer risk remains controversial. In this study, we investigated the influence of statin therapy on cancer incidence and mortality by conducting a comprehensive meta-analysis of randomized controlled trials. Methods Systematic searches by Cochrane, Embase, Medline, and PubMed were performed to locate data from eligible randomized controlled trials related to statin therapy and oncology. Our main endpoints were cancer incidence and mortality. Fixed-effects models were used in this study. Results This meta-analysis comprised thirty-five randomized controlled studies. Twenty-eight included studies reported cancer incidence, and eighteen reported cancer mortality. The pooled results indicated no reduction in cancer incidence with statins compared to placebo [OR = 0.99, 95% CI (0.95, 1.03)]. In addition, statins did not decrease cancer mortality [OR = 0.99, 95% CI (0.91, 1.07)]. This study also performed a number of subgroup analyses, which showed no effect of statins on cancer subtypes such as genitourinary and breast cancer. Neither the type of statin nor long-term treatment with statins had an effect on cancer incidence and mortality. Conclusion Through comprehensive analysis, we found that statin therapy does not reduce cancer incidence or mortality while protecting the cardiovascular system. Trial registration Prospero CRD42022377871.https://doi.org/10.1186/s12944-023-01955-4StatinCancerRandomized controlled trialIncidenceMortalityMeta-analysis |
| spellingShingle | Zijian Chen Panyun Wu Jiangang Wang Pengfei Chen Zhenfei Fang Fei Luo The association of statin therapy and cancer: a meta-analysis Lipids in Health and Disease Statin Cancer Randomized controlled trial Incidence Mortality Meta-analysis |
| title | The association of statin therapy and cancer: a meta-analysis |
| title_full | The association of statin therapy and cancer: a meta-analysis |
| title_fullStr | The association of statin therapy and cancer: a meta-analysis |
| title_full_unstemmed | The association of statin therapy and cancer: a meta-analysis |
| title_short | The association of statin therapy and cancer: a meta-analysis |
| title_sort | association of statin therapy and cancer a meta analysis |
| topic | Statin Cancer Randomized controlled trial Incidence Mortality Meta-analysis |
| url | https://doi.org/10.1186/s12944-023-01955-4 |
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