High‐Mobility Group Box 1–Signaling Inhibition With Glycyrrhizin Prevents Cerebral T‐Cell Infiltration After Cardiac Arrest

High‐Mobility Group Box 1–Signaling Inhibition With Glycyrrhizin Prevents Cerebral T‐Cell Infiltration After Cardiac Arrest

Background High‐mobility group box 1 (HMGB1) is a major promotor of ischemic injuries and aseptic inflammatory responses. We tested its inhibition on neurological outcome and systemic immune response after cardiac arrest (CA) in rabbits. Methods and Results After 10 minutes of ventricular fibrillati...

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Bibliographic Details
Main Authors: Emilie Boissady, Yara Abi Zeid Daou, Estelle Faucher, Matthias Kohlhauer, Fanny Lidouren, Cynthia El Hedjaj, Sophie Chateau‐Joubert, Hakim Hocini, Sophie Hue, Bijan Ghaleh, Renaud Tissier
Format: Article
Language:English
Published: Wiley 2023-02-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cardiac arrest
high‐mobility group box 1
inflammation
resuscitation
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.122.027749

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