Evaluation of the efficacy and safety of TWHF in diabetic nephropathy patients with overt proteinuria and normal eGFR
Background/purpose: The aim of this study was to evaluate the efficacy and safety of Tripterygium Wilfordii Hook F (TWHF) in DN patients with overt proteinuria and normal eGFR. Methods: 124 eligible DN patients were randomly assigned into two groups to receive either valsartan 160 mg/d treatment (co...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-03-01
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| Series: | Journal of the Formosan Medical Association |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S092966461930436X |
| _version_ | 1818337983441403904 |
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| author | Chang Xiong Li Li Wang Bo Huang Chen Liu XiaoWei Liu Hongbao Zhang Peng |
| author_facet | Chang Xiong Li Li Wang Bo Huang Chen Liu XiaoWei Liu Hongbao Zhang Peng |
| author_sort | Chang Xiong |
| collection | DOAJ |
| description | Background/purpose: The aim of this study was to evaluate the efficacy and safety of Tripterygium Wilfordii Hook F (TWHF) in DN patients with overt proteinuria and normal eGFR. Methods: 124 eligible DN patients were randomly assigned into two groups to receive either valsartan 160 mg/d treatment (control group) or TWHF 60 mg/d plus valsartan 160 mg/d treatments (TWHF group) for 24 weeks. The changes of clinical, biochemical data and adverse events during observation period were all analyzed. The primary endpoint was a reduction in 24-h urine protein excretion between baseline and the end of study, the secondary endpoint was to observe the change in estimated glomerular filtration rate (eGFR) between two groups. Results: After treatment, there was a more significant decrease in proteinuria in patients who received TWHF treatment (from 4.95 ± 1.27 g/24 h to 3.36 ± 0.83 g/24 h) compared to valsartan monotherapy (from 5.21 ± 1.59 g/24 h to 4.52 ± 1.06 g/24 h). The percentage change in urine protein excretion was −32.12% in TWHF group and −13.24% in valsartan group. Patients’ plasma albumin in TWHF group (from 32.53 ± 5.24 g/L to 36.91 ± 4.42 g/L) was higher than that in control group (from 33.18 ± 4.87 g/L to 34.67 ± 4.75 g/L). No significant change in blood pressure, blood glucose, eGFR, and serum potassium was observed. But the adverse events in TWHF group were higher than those in control group. Conclusion: TWHF is more effective than valsartan monotherapy in reduction of proteinuria in DN patients with overt proteinuria and normal eGFR, but with more adverse effects. Keywords: Diabetes mellitus, Diabetic nephropathy, Tripterygium wilfordii hook F, Valsartan |
| first_indexed | 2024-12-13T15:03:53Z |
| format | Article |
| id | doaj.art-d5d738cf9e2a47f2af03361b417e4579 |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-12-13T15:03:53Z |
| publishDate | 2020-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-d5d738cf9e2a47f2af03361b417e45792022-12-21T23:41:04ZengElsevierJournal of the Formosan Medical Association0929-66462020-03-011193685692Evaluation of the efficacy and safety of TWHF in diabetic nephropathy patients with overt proteinuria and normal eGFRChang Xiong0Li Li1Wang Bo2Huang Chen3Liu XiaoWei4Liu Hongbao5Zhang Peng6Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, Shaanxi Province, China; Department of Nephrology, Yulin First Hospital, Yulin, 718000, Shaanxi Province, ChinaDepartment of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, Shaanxi Province, ChinaDepartment of Clinical Epidemiology, Fourth Military Medical University, Xi'an, 710032, Shaanxi Province, ChinaDepartment of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, Shaanxi Province, ChinaDepartment of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, Shaanxi Province, ChinaDepartment of Nephrology, Tangdu Hospital, Fourth Military Medical University, Xi'an, 710038, Shaanxi Province, China; Corresponding author.Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, Shaanxi Province, China; Corresponding author. Department of Nephrology Xijing Hospital, Fourth Military Medical University No. 127 West Changle Road, Xi'an, 710032, Shaanxi province, China.Background/purpose: The aim of this study was to evaluate the efficacy and safety of Tripterygium Wilfordii Hook F (TWHF) in DN patients with overt proteinuria and normal eGFR. Methods: 124 eligible DN patients were randomly assigned into two groups to receive either valsartan 160 mg/d treatment (control group) or TWHF 60 mg/d plus valsartan 160 mg/d treatments (TWHF group) for 24 weeks. The changes of clinical, biochemical data and adverse events during observation period were all analyzed. The primary endpoint was a reduction in 24-h urine protein excretion between baseline and the end of study, the secondary endpoint was to observe the change in estimated glomerular filtration rate (eGFR) between two groups. Results: After treatment, there was a more significant decrease in proteinuria in patients who received TWHF treatment (from 4.95 ± 1.27 g/24 h to 3.36 ± 0.83 g/24 h) compared to valsartan monotherapy (from 5.21 ± 1.59 g/24 h to 4.52 ± 1.06 g/24 h). The percentage change in urine protein excretion was −32.12% in TWHF group and −13.24% in valsartan group. Patients’ plasma albumin in TWHF group (from 32.53 ± 5.24 g/L to 36.91 ± 4.42 g/L) was higher than that in control group (from 33.18 ± 4.87 g/L to 34.67 ± 4.75 g/L). No significant change in blood pressure, blood glucose, eGFR, and serum potassium was observed. But the adverse events in TWHF group were higher than those in control group. Conclusion: TWHF is more effective than valsartan monotherapy in reduction of proteinuria in DN patients with overt proteinuria and normal eGFR, but with more adverse effects. Keywords: Diabetes mellitus, Diabetic nephropathy, Tripterygium wilfordii hook F, Valsartanhttp://www.sciencedirect.com/science/article/pii/S092966461930436X |
| spellingShingle | Chang Xiong Li Li Wang Bo Huang Chen Liu XiaoWei Liu Hongbao Zhang Peng Evaluation of the efficacy and safety of TWHF in diabetic nephropathy patients with overt proteinuria and normal eGFR Journal of the Formosan Medical Association |
| title | Evaluation of the efficacy and safety of TWHF in diabetic nephropathy patients with overt proteinuria and normal eGFR |
| title_full | Evaluation of the efficacy and safety of TWHF in diabetic nephropathy patients with overt proteinuria and normal eGFR |
| title_fullStr | Evaluation of the efficacy and safety of TWHF in diabetic nephropathy patients with overt proteinuria and normal eGFR |
| title_full_unstemmed | Evaluation of the efficacy and safety of TWHF in diabetic nephropathy patients with overt proteinuria and normal eGFR |
| title_short | Evaluation of the efficacy and safety of TWHF in diabetic nephropathy patients with overt proteinuria and normal eGFR |
| title_sort | evaluation of the efficacy and safety of twhf in diabetic nephropathy patients with overt proteinuria and normal egfr |
| url | http://www.sciencedirect.com/science/article/pii/S092966461930436X |
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