Insulin Resistance is a Risk Factor for Early Miscarriage and Macrosomia in Patients With Polycystic Ovary Syndrome From the First Embryo Transfer Cycle: A Retrospective Cohort Study
ObjectiveThe objective of the study was to explore the effect of insulin resistance on pregnancy outcomes in patients with polycystic ovary syndrome (PCOS) from the first embryo transfer cycle.DesignThis was a single-center, retrospective, observational cohort study.PatientsIncluded in the study wer...
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| Format: | Article |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.853473/full |
| _version_ | 1811334160143351808 |
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| author | Yuanhui Chen Yuanhui Chen Jiayu Guo Jiayu Guo Qingwen Zhang Cuilian Zhang |
| author_facet | Yuanhui Chen Yuanhui Chen Jiayu Guo Jiayu Guo Qingwen Zhang Cuilian Zhang |
| author_sort | Yuanhui Chen |
| collection | DOAJ |
| description | ObjectiveThe objective of the study was to explore the effect of insulin resistance on pregnancy outcomes in patients with polycystic ovary syndrome (PCOS) from the first embryo transfer cycle.DesignThis was a single-center, retrospective, observational cohort study.PatientsIncluded in the study were women with PCOS for the first embryo transfer.Main Outcome MeasuresEarly miscarriage rate and macrosomia rate were the main outcome measures.ResultsWith increased HOMA-IR, the early miscarriage rate (7.14, 13.21, and 16.22%, respectively; P = 0.039), macrosomia rate (5.78, 11.79, and 17.58%, respectively; P = 0.026) and the incidence of gestational diabetes (GDM) (10.00, 14.50, and 25.67% respectively; P = 0.002) significantly increased, while the live birth rate markedly decreased (63.03, 55.27, and 47.88%, respectively; P = 0.004). No significant difference was found in clinical pregnancy rate, late miscarriage rate, low birthweight rate and baby gender ratio (all P >0.05). After adjusting for confounding factors, HOMA-IR was an independent risk factor of early miscarriage rate and macrosomia rate.ConclusionInsulin resistance is an independent risk factor for early miscarriage and macrosomia in PCOS patients during the first embryo transfer cycle. It is essential to give more attention before and after pregnancy for PCOS women with high HOMA-IR. |
| first_indexed | 2024-04-13T17:03:42Z |
| format | Article |
| id | doaj.art-d5d86d2316d841eaad3dbc0bedd7dc63 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-13T17:03:42Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-d5d86d2316d841eaad3dbc0bedd7dc632022-12-22T02:38:33ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-04-011310.3389/fendo.2022.853473853473Insulin Resistance is a Risk Factor for Early Miscarriage and Macrosomia in Patients With Polycystic Ovary Syndrome From the First Embryo Transfer Cycle: A Retrospective Cohort StudyYuanhui Chen0Yuanhui Chen1Jiayu Guo2Jiayu Guo3Qingwen Zhang4Cuilian Zhang5Reproductive Medical Center, People’s Hospital of Zhengzhou University, Zhengzhou, ChinaReproductive Medical Center, Henan Provincial People’s Hospital, Zhengzhou, ChinaReproductive Medical Center, People’s Hospital of Zhengzhou University, Zhengzhou, ChinaReproductive Medical Center, Henan Provincial People’s Hospital, Zhengzhou, ChinaReproductive Medical Center, Henan Provincial People’s Hospital, Zhengzhou, ChinaReproductive Medical Center, Henan Provincial People’s Hospital, Zhengzhou, ChinaObjectiveThe objective of the study was to explore the effect of insulin resistance on pregnancy outcomes in patients with polycystic ovary syndrome (PCOS) from the first embryo transfer cycle.DesignThis was a single-center, retrospective, observational cohort study.PatientsIncluded in the study were women with PCOS for the first embryo transfer.Main Outcome MeasuresEarly miscarriage rate and macrosomia rate were the main outcome measures.ResultsWith increased HOMA-IR, the early miscarriage rate (7.14, 13.21, and 16.22%, respectively; P = 0.039), macrosomia rate (5.78, 11.79, and 17.58%, respectively; P = 0.026) and the incidence of gestational diabetes (GDM) (10.00, 14.50, and 25.67% respectively; P = 0.002) significantly increased, while the live birth rate markedly decreased (63.03, 55.27, and 47.88%, respectively; P = 0.004). No significant difference was found in clinical pregnancy rate, late miscarriage rate, low birthweight rate and baby gender ratio (all P >0.05). After adjusting for confounding factors, HOMA-IR was an independent risk factor of early miscarriage rate and macrosomia rate.ConclusionInsulin resistance is an independent risk factor for early miscarriage and macrosomia in PCOS patients during the first embryo transfer cycle. It is essential to give more attention before and after pregnancy for PCOS women with high HOMA-IR.https://www.frontiersin.org/articles/10.3389/fendo.2022.853473/fullinsulin resistancepolycystic ovary syndromeearly miscarriagemacrosomiain vitro fertilization |
| spellingShingle | Yuanhui Chen Yuanhui Chen Jiayu Guo Jiayu Guo Qingwen Zhang Cuilian Zhang Insulin Resistance is a Risk Factor for Early Miscarriage and Macrosomia in Patients With Polycystic Ovary Syndrome From the First Embryo Transfer Cycle: A Retrospective Cohort Study Frontiers in Endocrinology insulin resistance polycystic ovary syndrome early miscarriage macrosomia in vitro fertilization |
| title | Insulin Resistance is a Risk Factor for Early Miscarriage and Macrosomia in Patients With Polycystic Ovary Syndrome From the First Embryo Transfer Cycle: A Retrospective Cohort Study |
| title_full | Insulin Resistance is a Risk Factor for Early Miscarriage and Macrosomia in Patients With Polycystic Ovary Syndrome From the First Embryo Transfer Cycle: A Retrospective Cohort Study |
| title_fullStr | Insulin Resistance is a Risk Factor for Early Miscarriage and Macrosomia in Patients With Polycystic Ovary Syndrome From the First Embryo Transfer Cycle: A Retrospective Cohort Study |
| title_full_unstemmed | Insulin Resistance is a Risk Factor for Early Miscarriage and Macrosomia in Patients With Polycystic Ovary Syndrome From the First Embryo Transfer Cycle: A Retrospective Cohort Study |
| title_short | Insulin Resistance is a Risk Factor for Early Miscarriage and Macrosomia in Patients With Polycystic Ovary Syndrome From the First Embryo Transfer Cycle: A Retrospective Cohort Study |
| title_sort | insulin resistance is a risk factor for early miscarriage and macrosomia in patients with polycystic ovary syndrome from the first embryo transfer cycle a retrospective cohort study |
| topic | insulin resistance polycystic ovary syndrome early miscarriage macrosomia in vitro fertilization |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.853473/full |
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