A novel Bcr-Abl–mTOR–eIF4A axis regulates IRES-mediated translation of LEF-1

A novel Bcr-Abl–mTOR–eIF4A axis regulates IRES-mediated translation of LEF-1

Internal ribosome entry sites (IRESs) in cellular mRNAs direct expression of growth-promoting factors through an alternative translation mechanism that has yet to be fully defined. Lymphoid enhancer factor-1 (LEF-1), a Wnt-mediating transcription factor important for cell survival and metastasis in...

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Bibliographic Details
Main Authors: Becky Pinjou Tsai, Judith Jimenez, Sharon Lim, Kerry D. Fitzgerald, Min Zhang, Charles T. H. Chuah, Haley Axelrod, Luke Nelson, S. Tiong Ong, Bert L. Semler, Marian L. Waterman
Format: Article
Language:English
Published: The Royal Society 2014-01-01
Series:Open Biology
Subjects:
lef-1
bcr-abl
ires
mtor
eif4a
pp242
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.140180

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