Clinical Characteristics of Patients With HNF1-alpha MODY: A Literature Review and Retrospective Chart Review

Clinical Characteristics of Patients With HNF1-alpha MODY: A Literature Review and Retrospective Chart Review

The clinical manifestation of hepatocyte nuclear factor-1-alpha (HNF1-alpha) maturity-onset diabetes of the young (MODY) is highly variable. This study aims to investigate the clinical characteristics of patients with HNF1-alpha MODY in general, by geographical regions (Asian or non-Asian), HNF1-alp...

Full description

Bibliographic Details
Main Authors:	Qinying Zhao, Li Ding, Ying Yang, Jinhong Sun, Min Wang, Xin Li, Ming Liu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-06-01
Series:	Frontiers in Endocrinology
Subjects:	HNF1-alpha MODY diabetes HNF1-alpha mutations pancreatic islet autoantibody diabetic complication
Online Access:	https://www.frontiersin.org/articles/10.3389/fendo.2022.900489/full

Similar Items

MODY probability calculator for GCK and HNF1A screening in a multiethnic background population
by: Roberta Magalhães Tarantino, et al.

Genetic and Clinical Characterization of Patients with HNF1B-Related MODY in Croatia
by: Maja Baretić, et al.
Published: (2023-06-01)

Variants influencing age at diagnosis of HNF1A-MODY
by: Agnieszka H. Ludwig-Słomczyńska, et al.
Published: (2022-09-01)

Infrequent presentations of MODY diabetes, the example of MODY type 5 and the novo forms of MODY type 2
by: Alejandro De Dios, et al.
Published: (2018-03-01)

MODY3 in the child with type 2 diabetes mellitus phenotype: case report
by: Tamara Leonidovna Kuraeva, et al.
Published: (2013-06-01)

Incidence of HNF1A and GCK MODY Variants in a South African Population
by: Matsha TE, et al.
Published: (2020-12-01)

Variants of the HNF4A and HNF1A genes in patients with impaired glucose metabolism and dyslipidemia
by: Dinara E. Ivanoshchuk, et al.
Published: (2022-01-01)

Genetic testing for maturity-onset diabetes of the young resulting in an upgraded genetic classification of an HNF1A gene variant: a case report
by: Naama Pollack-Schreiber, et al.
Published: (2023-06-01)

Identification of novel variants in HNF1-alpha gene in maturity onset diabetes in young adults (MODY) subjects of Eastern India
by: Chaitry Ghosal, et al.
Published: (2013-01-01)

Semaglutide as a potential therapeutic alternative for HNF1B-MODY: a case study
by: Angham Almutair, et al.
Published: (2024-03-01)

Maturity-onset diabetes of the young secondary to HNF1B variants (HNF1B-MODY): a series of 10 patients from a single diabetes center
by: Sara Amaral, et al.
Published: (2023-02-01)

Hidden MODY—Looking for a Needle in a Haystack
by: Jana Urbanová, et al.
Published: (2018-07-01)

HNF1A Mutations and Beta Cell Dysfunction in Diabetes
by: Yasutaka Miyachi, et al.
Published: (2022-03-01)

CLINICAL TREATMENT FOR MODY DIABETES
by: Alejandro De Dios, et al.
Published: (2014-12-01)

Maturity-onset diabetes of the young type 5 a MULTISYSTEMIC disease: a CASE report of a novel mutation in the HNF1B gene and literature review
by: Juan Camilo Mateus, et al.
Published: (2020-08-01)

Molecular Dynamics Simulations Predict that rSNP Located in the <i>HNF-1α</i> Gene Promotor Region Linked with MODY3 and Hepatocellular Carcinoma Promotes Stronger Binding of the HNF-4α Transcription Factor
by: Eva Španinger, et al.
Published: (2020-12-01)

Case Report: Identification of an HNF1B p.Arg527Gln mutation in a Maltese patient with atypical early onset diabetes and diabetic nephropathy
by: Nikolai Paul Pace, et al.
Published: (2018-05-01)

Case Report: A case of HNF1B mutation patient with first presentation of diabetic ketosis
by: Shenghui Ge, et al.
Published: (2022-08-01)

HNF1A POU Domain Mutations Found in Japanese Liver Cancer Patients Cause Downregulation of <i>HNF4A</i> Promoter Activity with Possible Disruption in Transcription Networks
by: Effi Haque, et al.
Published: (2022-02-01)

Report of Prolonged Neonatal Hypoglycemia in Three Infants of Mothers With HNF1A Maturity-Onset Diabetes of the Youth
by: Sara Jane Cromer, MD, et al.
Published: (2022-09-01)

A Comprehensive Analysis of Hungarian MODY Patients—Part I: Gene Panel Sequencing Reveals Pathogenic Mutations in <i>HNF1A</i>, <i>HNF1B</i>, <i>HNF4A</i>, <i>ABCC8</i> and <i>INS</i> Genes
by: Zsolt Gaál, et al.
Published: (2021-07-01)

Structural properties of the HNF-1A transactivation domain
by: Laura Kind, et al.
Published: (2023-10-01)

The Genetic Spectrum of Maturity-Onset Diabetes of the Young (MODY) in Qatar, a Population-Based Study
by: Asma A. Elashi, et al.
Published: (2022-12-01)

Loss of HNF1α Function Contributes to Hepatocyte Proliferation and Abnormal Cholesterol Metabolism via Downregulating miR-122: A Novel Mechanism of MODY3
by: Hu M, et al.
Published: (2020-03-01)

NGS Analysis Revealed Digenic Heterozygous <i>GCK</i> and <i>HNF1A</i> Variants in a Child with Mild Hyperglycemia: A Case Report
by: Fernanda Iafusco, et al.
Published: (2021-06-01)

Disruption of Tumor Suppressors HNF4α/HNF1α Causes Tumorigenesis in Liver
by: Aamir Salam Teeli, et al.
Published: (2021-10-01)

Maturity onset diabetes of the young: Diagnosis and treatment options
by: Serghei Covanțev, et al.
Published: (2016-12-01)

Prevalence and clinical profile of maturity onset diabetes of the young among people with diabetes attending a tertiary care centre
by: Javaid Ahmad Bhat, et al.
Published: (2022-01-01)

The Clinical Characteristics and Gene Mutations of Maturity-Onset Diabetes of the Young Type 5 in Sixty-One Patients
by: Shenghui Ge, et al.
Published: (2022-06-01)

Frequency of HNF4A-P.I463V Variant in the Tunisian North-African Population and Its Relation with Diabetes Mellitus
by: Abdelbasset Amara, et al.
Published: (2015-03-01)

Transcriptomically Revealed Oligo-Fucoidan Enhances the Immune System and Protects Hepatocytes via the ASGPR/STAT3/HNF4A Axis
by: Chun-Chia Cheng, et al.
Published: (2020-06-01)

The Roles of Long Noncoding RNAs HNF1α-AS1 and HNF4α-AS1 in Drug Metabolism and Human Diseases
by: Liming Chen, et al.
Published: (2020-06-01)

Maturity Onset Diabetes of the Young—New Approaches for Disease Modelling
by: Dawid Skoczek, et al.
Published: (2021-07-01)

Identification and precision therapy for three maturity-onset diabetes of the young (MODY) families caused by mutations in the HNF4A gene
by: Juan Zhang, et al.
Published: (2023-08-01)

A Single Nucleotide Variant in HNF-1β is associated with Maturity-Onset Diabetes of the Young in a Large Chinese Family
by: Peng ZHOU, et al.
Published: (2016-02-01)

The Landscape of HNF1B Deficiency: A Syndrome Not Yet Fully Explored
by: Alessandro Gambella, et al.
Published: (2023-01-01)

Structural insights into the HNF4 biology
by: Brice Beinsteiner, et al.
Published: (2023-06-01)

Diagnosis and Treatment of MODY: An Updated Mini Review
by: Abegail Tshivhase, et al.
Published: (2021-10-01)

Review of neurodevelopmental disorders in patients with HNF1B gene variations
by: Clara Marie Nittel, et al.
Published: (2023-03-01)

The Hepatocyte nuclear factor-1 alpha (HNF1A) gene is associated with fatness and loin muscle area in the pig
by: B. Fan, et al.
Published: (2010-01-01)