Limited effects of azithromycin on the oropharyngeal microbiome in children with CF and early pseudomonas infection

Limited effects of azithromycin on the oropharyngeal microbiome in children with CF and early pseudomonas infection

Abstract Background Tobramycin inhalation solution (TIS) and chronic azithromycin (AZ) have known clinical benefits for children with CF, likely due to antimicrobial and anti-inflammatory activity. The effects of chronic AZ in combination with TIS on the airway microbiome have not been extensively i...

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Bibliographic Details
Main Authors: Brandie D. Wagner, Edith T. Zemanick, Scott D. Sagel, Charles E. Robertson, Mark J. Stevens, Nicole Mayer-Hamblett, George Retsch-Bogart, Bonnie W. Ramsey, J. Kirk Harris
Format: Article
Language:English
Published: BMC 2023-10-01
Series:BMC Microbiology
Subjects:
Microbiome
Oropharyngeal swab
Macrolides
Pulmonary exacerbation
Tobramycin
Beta diversity
Online Access:https://doi.org/10.1186/s12866-023-03073-8

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