Central role of SREBP-2 in the pathogenesis of osteoarthritis.

Central role of SREBP-2 in the pathogenesis of osteoarthritis.

Recent studies have implied that osteoarthritis (OA) is a metabolic disease linked to deregulation of genes involved in lipid metabolism and cholesterol efflux. Sterol Regulatory Element Binding Proteins (SREBPs) are transcription factors regulating lipid metabolism with so far no association with O...

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Bibliographic Details
Main Authors: Fotini Kostopoulou, Vasiliki Gkretsi, Konstantinos N Malizos, Dimitrios Iliopoulos, Pagona Oikonomou, Lazaros Poultsides, Aspasia Tsezou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3360703?pdf=render

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