Endogenous opioids regulate moment-to-moment neuronal communication and excitability
The endogenous opioid system regulates fear and anxiety, but the underlying cellular mechanism is unclear. Winterset al. shows that in the intercalated cells (ITC) of the amygdala, endogenous opioids suppress glutamatergic inputs via the δ-opioid receptor presynaptically, and reduce the excitability...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms14611 |
| _version_ | 1818422844054306816 |
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| author | Bryony L. Winters Gabrielle C. Gregoriou Sarah A. Kissiwaa Oliver A. Wells Danashi I. Medagoda Sam M. Hermes Neil T. Burford Andrew Alt Sue A. Aicher Elena E. Bagley |
| author_facet | Bryony L. Winters Gabrielle C. Gregoriou Sarah A. Kissiwaa Oliver A. Wells Danashi I. Medagoda Sam M. Hermes Neil T. Burford Andrew Alt Sue A. Aicher Elena E. Bagley |
| author_sort | Bryony L. Winters |
| collection | DOAJ |
| description | The endogenous opioid system regulates fear and anxiety, but the underlying cellular mechanism is unclear. Winterset al. shows that in the intercalated cells (ITC) of the amygdala, endogenous opioids suppress glutamatergic inputs via the δ-opioid receptor presynaptically, and reduce the excitability of ITCs via the μ-opioid receptor postsynaptically. |
| first_indexed | 2024-12-14T13:32:42Z |
| format | Article |
| id | doaj.art-d5dae2c2b5f34eefb24b94cf971ec920 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T13:32:42Z |
| publishDate | 2017-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d5dae2c2b5f34eefb24b94cf971ec9202022-12-21T22:59:40ZengNature PortfolioNature Communications2041-17232017-03-018111510.1038/ncomms14611Endogenous opioids regulate moment-to-moment neuronal communication and excitabilityBryony L. Winters0Gabrielle C. Gregoriou1Sarah A. Kissiwaa2Oliver A. Wells3Danashi I. Medagoda4Sam M. Hermes5Neil T. Burford6Andrew Alt7Sue A. Aicher8Elena E. Bagley9Discipline of Pharmacology, School of Medical Sciences, University of SydneyDiscipline of Pharmacology, School of Medical Sciences, University of SydneyDiscipline of Pharmacology, School of Medical Sciences, University of SydneyDiscipline of Pharmacology, School of Medical Sciences, University of SydneyDiscipline of Pharmacology, School of Medical Sciences, University of SydneyDepartment of Physiology and Pharmacology, Oregon Health and Science UniversityBristol-Myers SquibbBristol-Myers SquibbDepartment of Physiology and Pharmacology, Oregon Health and Science UniversityDiscipline of Pharmacology, School of Medical Sciences, University of SydneyThe endogenous opioid system regulates fear and anxiety, but the underlying cellular mechanism is unclear. Winterset al. shows that in the intercalated cells (ITC) of the amygdala, endogenous opioids suppress glutamatergic inputs via the δ-opioid receptor presynaptically, and reduce the excitability of ITCs via the μ-opioid receptor postsynaptically.https://doi.org/10.1038/ncomms14611 |
| spellingShingle | Bryony L. Winters Gabrielle C. Gregoriou Sarah A. Kissiwaa Oliver A. Wells Danashi I. Medagoda Sam M. Hermes Neil T. Burford Andrew Alt Sue A. Aicher Elena E. Bagley Endogenous opioids regulate moment-to-moment neuronal communication and excitability Nature Communications |
| title | Endogenous opioids regulate moment-to-moment neuronal communication and excitability |
| title_full | Endogenous opioids regulate moment-to-moment neuronal communication and excitability |
| title_fullStr | Endogenous opioids regulate moment-to-moment neuronal communication and excitability |
| title_full_unstemmed | Endogenous opioids regulate moment-to-moment neuronal communication and excitability |
| title_short | Endogenous opioids regulate moment-to-moment neuronal communication and excitability |
| title_sort | endogenous opioids regulate moment to moment neuronal communication and excitability |
| url | https://doi.org/10.1038/ncomms14611 |
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