Host Immune Responses to Arthritogenic Alphavirus Infection, with Emphasis on Type I IFN Responses
Arthritogenic alphaviruses, such as Ross River virus, chikungunya virus and O’nyong-nyong virus, cause endemic disease globally and are a major public health concern. The hallmarks of arthritogenic alphavirus disease are debilitating pain, and potentially chronic inflammation of the muscles, thus in...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Compuscript Ltd
2022-08-01
|
| Series: | Zoonoses |
| Online Access: | https://www.scienceopen.com/hosted-document?doi=10.15212/ZOONOSES-2022-0028 |
| _version_ | 1827591995057504256 |
|---|---|
| author | Patrick Chun Hean Tang Wern Hann Ng Xiang Liu |
| author_facet | Patrick Chun Hean Tang Wern Hann Ng Xiang Liu |
| author_sort | Patrick Chun Hean Tang |
| collection | DOAJ |
| description | Arthritogenic alphaviruses, such as Ross River virus, chikungunya virus and O’nyong-nyong virus, cause endemic disease globally and are a major public health concern. The hallmarks of arthritogenic alphavirus disease are debilitating pain, and potentially chronic inflammation of the muscles, thus influencing quality of life. The type I IFN response is a major component of the innate immune response against arthritogenic alphaviruses, and is essential in inhibiting viral replication and dissemination. Type I IFNs are induced during early stages of infection and are essential for the activation of the antiviral innate immune response. They also link the innate immune response and the activation of adaptive immunity. This review focuses on the host immune response, particularly that involving type I IFN, in arthritogenic alphavirus disease. |
| first_indexed | 2024-03-09T01:40:29Z |
| format | Article |
| id | doaj.art-d5db074f0c8d4222bcb26a0e40835478 |
| institution | Directory Open Access Journal |
| issn | 2737-7466 2737-7474 |
| language | English |
| last_indexed | 2024-03-09T01:40:29Z |
| publishDate | 2022-08-01 |
| publisher | Compuscript Ltd |
| record_format | Article |
| series | Zoonoses |
| spelling | doaj.art-d5db074f0c8d4222bcb26a0e408354782023-12-08T17:00:37ZengCompuscript LtdZoonoses2737-74662737-74742022-08-012197210.15212/ZOONOSES-2022-0028Host Immune Responses to Arthritogenic Alphavirus Infection, with Emphasis on Type I IFN ResponsesPatrick Chun Hean TangWern Hann NgXiang LiuArthritogenic alphaviruses, such as Ross River virus, chikungunya virus and O’nyong-nyong virus, cause endemic disease globally and are a major public health concern. The hallmarks of arthritogenic alphavirus disease are debilitating pain, and potentially chronic inflammation of the muscles, thus influencing quality of life. The type I IFN response is a major component of the innate immune response against arthritogenic alphaviruses, and is essential in inhibiting viral replication and dissemination. Type I IFNs are induced during early stages of infection and are essential for the activation of the antiviral innate immune response. They also link the innate immune response and the activation of adaptive immunity. This review focuses on the host immune response, particularly that involving type I IFN, in arthritogenic alphavirus disease.https://www.scienceopen.com/hosted-document?doi=10.15212/ZOONOSES-2022-0028 |
| spellingShingle | Patrick Chun Hean Tang Wern Hann Ng Xiang Liu Host Immune Responses to Arthritogenic Alphavirus Infection, with Emphasis on Type I IFN Responses Zoonoses |
| title | Host Immune Responses to Arthritogenic Alphavirus Infection, with Emphasis on Type I IFN Responses |
| title_full | Host Immune Responses to Arthritogenic Alphavirus Infection, with Emphasis on Type I IFN Responses |
| title_fullStr | Host Immune Responses to Arthritogenic Alphavirus Infection, with Emphasis on Type I IFN Responses |
| title_full_unstemmed | Host Immune Responses to Arthritogenic Alphavirus Infection, with Emphasis on Type I IFN Responses |
| title_short | Host Immune Responses to Arthritogenic Alphavirus Infection, with Emphasis on Type I IFN Responses |
| title_sort | host immune responses to arthritogenic alphavirus infection with emphasis on type i ifn responses |
| url | https://www.scienceopen.com/hosted-document?doi=10.15212/ZOONOSES-2022-0028 |
| work_keys_str_mv | AT patrickchunheantang hostimmuneresponsestoarthritogenicalphavirusinfectionwithemphasisontypeiifnresponses AT wernhannng hostimmuneresponsestoarthritogenicalphavirusinfectionwithemphasisontypeiifnresponses AT xiangliu hostimmuneresponsestoarthritogenicalphavirusinfectionwithemphasisontypeiifnresponses |