Impaired tissue homing by the Ikzf3N159S variant is mediated by interfering with Ikaros function

Impaired tissue homing by the Ikzf3N159S variant is mediated by interfering with Ikaros function

AIOLOS, encoded by IKZF3, is a member of the IKZF family of proteins that plays an important role in regulating late B-cell differentiation. Human individuals heterozygous for the AIOLOS p.N160S variant displayed impaired humoral immune responses as well as impaired B and T cell development. We have...

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Bibliographic Details
Main Authors: Jingjie Chang, Motoi Yamashita, Aditya K. Padhi, Kam Y. J. Zhang, Ichiro Taniuchi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
IKZF family proteins
lymphocyte homing
CD62L
immune deficiency
heterodimeric interference
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1239779/full

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