Pioglitazone Protects Against Renal Ischemia-Reperfusion Injury via the AMP-Activated Protein Kinase-Regulated Autophagy Pathway

Pioglitazone Protects Against Renal Ischemia-Reperfusion Injury via the AMP-Activated Protein Kinase-Regulated Autophagy Pathway

Renal ischemia-reperfusion injury (IRI) is a major cause of acute renal failure. Our previous studies have shown that pioglitazone, a peroxisome proliferators-activated receptor (PPAR)-γ agonist used in type 2 diabetes, protects against renal IRI; however, the molecular mechanism underlying the reno...

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Bibliographic Details
Main Authors: Wenlin Chen, Xiaoqing Xi, Shuangyang Zhang, Cong Zou, Renrui Kuang, Zhenfeng Ye, Yawei Huang, Honglin Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Pharmacology
Subjects:
pioglitazone
renal ischemia reperfusion injury
peroxisome proliferators-activated receptor-γ
autophagy
cell apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00851/full

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