Anti-miR-223-5p Ameliorates Ischemic Damage and Improves Neurological Function by Preventing NCKX2 Downregulation after Ischemia in Rats

Anti-miR-223-5p Ameliorates Ischemic Damage and Improves Neurological Function by Preventing NCKX2 Downregulation after Ischemia in Rats

It has been demonstrated that the K+-dependent Na+/Ca2+ exchanger, NCKX2, is a new promising stroke neuroprotective target. However, because no pharmacological activator of NCKX2 is still available, microRNA (miRNA) may represent an alternative method to modulate NCKX2 expression. In particular, by...

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Bibliographic Details
Main Authors: Ornella Cuomo, Pasquale Cepparulo, Serenella Anzilotti, Angelo Serani, Rossana Sirabella, Paola Brancaccio, Natascia Guida, Valeria Valsecchi, Antonio Vinciguerra, Pasquale Molinaro, Luigi Formisano, Lucio Annunziato, Giuseppe Pignataro, MD PhD
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Molecular Therapy: Nucleic Acids
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253119303324

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