Polypill therapy and frailty in elderly: Time to stop treating everything
Background: Frailty is a reversible age-related condition of increased vulnerability and risk of death or unplanned hospitalization. Frailty and polypill therapy are common in elderly, although little is known about the impact, they may have on each other. Aims and Objective: The study was a pros...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2021-04-01
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| Series: | Asian Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/33182 |
| _version_ | 1818734056936833024 |
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| author | Sunil Kumar Parth Godhiwala Amrutha Garikapati Shraddha Jain |
| author_facet | Sunil Kumar Parth Godhiwala Amrutha Garikapati Shraddha Jain |
| author_sort | Sunil Kumar |
| collection | DOAJ |
| description | Background: Frailty is a reversible age-related condition of increased vulnerability and risk of death or unplanned hospitalization. Frailty and polypill therapy are common in elderly, although little is known about the impact, they may have on each other.
Aims and Objective: The study was a prospective observational study, designed with an aim to observe the six-month and one-year outcomes of elderly patients on polypill therapy.
Material and Methods: Three hundred forty-two patients aged more than 60 years on polypill treatment were enrolled in this study, which were on regular follow up in our rural hospital at geriatric units of medicine department.
Results: At the end of one year, 38.1% were in severe frailty (FIRE >0.7) category, out of which death happened at the end of one year were 41.6%. 47.6% required repeated hospitalisations that were on polypill therapy.
Conclusions: A reduction of polypill therapy could be a cautious strategy to prevent and manage frailty. Further research is needed to confirm the possible benefits of reducing polypill in the development, reversion or delay of frailty. |
| first_indexed | 2024-12-17T23:59:18Z |
| format | Article |
| id | doaj.art-d5de99f22c9942b8be990bc6e29ab4e4 |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-12-17T23:59:18Z |
| publishDate | 2021-04-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-d5de99f22c9942b8be990bc6e29ab4e42022-12-21T21:27:59ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762021-04-011243942https://doi.org/10.3126/ajms.v12i4.33182Polypill therapy and frailty in elderly: Time to stop treating everythingSunil Kumar 0https://orcid.org/0000-0001-9905-4831Parth Godhiwala 1https://orcid.org/0000-0003-0869-9816Amrutha Garikapati 2https://orcid.org/0000-0003-0998-9874Shraddha Jain 3https://orcid.org/0000-0003-1455-1850Professor, Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Wardha, Maharashtra, India Post Graduate Resident, Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Wardha, Maharashtra, India Post Graduate Resident, Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Wardha, Maharashtra, India Professor, Department of ENT, Jawahar Lal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Wardha, Maharashtra, India Background: Frailty is a reversible age-related condition of increased vulnerability and risk of death or unplanned hospitalization. Frailty and polypill therapy are common in elderly, although little is known about the impact, they may have on each other. Aims and Objective: The study was a prospective observational study, designed with an aim to observe the six-month and one-year outcomes of elderly patients on polypill therapy. Material and Methods: Three hundred forty-two patients aged more than 60 years on polypill treatment were enrolled in this study, which were on regular follow up in our rural hospital at geriatric units of medicine department. Results: At the end of one year, 38.1% were in severe frailty (FIRE >0.7) category, out of which death happened at the end of one year were 41.6%. 47.6% required repeated hospitalisations that were on polypill therapy. Conclusions: A reduction of polypill therapy could be a cautious strategy to prevent and manage frailty. Further research is needed to confirm the possible benefits of reducing polypill in the development, reversion or delay of frailty.https://www.nepjol.info/index.php/AJMS/article/view/33182elderlyfrailhospitalizationmortalitypolypill |
| spellingShingle | Sunil Kumar Parth Godhiwala Amrutha Garikapati Shraddha Jain Polypill therapy and frailty in elderly: Time to stop treating everything Asian Journal of Medical Sciences elderly frail hospitalization mortality polypill |
| title | Polypill therapy and frailty in elderly: Time to stop treating everything |
| title_full | Polypill therapy and frailty in elderly: Time to stop treating everything |
| title_fullStr | Polypill therapy and frailty in elderly: Time to stop treating everything |
| title_full_unstemmed | Polypill therapy and frailty in elderly: Time to stop treating everything |
| title_short | Polypill therapy and frailty in elderly: Time to stop treating everything |
| title_sort | polypill therapy and frailty in elderly time to stop treating everything |
| topic | elderly frail hospitalization mortality polypill |
| url | https://www.nepjol.info/index.php/AJMS/article/view/33182 |
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