Growth indicators and related factors in children under 6 years in Shiraz city in 2008
Introduction: Oxidative damage is one of the major factors that lead to cell damage, organ dysfunction and mortality in sepsis. Thus, an attractive candidate for pharmacologic treatment of the septic syndrome is deferoxamine (DFX), an antioxidant iron chelator used for the removal of iron and a pote...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | fas |
| Published: |
Jahrom University of Medical Sciences
2012-04-01
|
| Series: | فصلنامه دانشگاه علوم پزشکی جهرم |
| Subjects: | |
| Online Access: | http://jmj.jums.ac.ir/article-1-70-en.html |
| _version_ | 1819059755013898240 |
|---|---|
| author | MohammadSadegh Sanie SeyedMmohammad Hoseinipanah Poran Hajian |
| author_facet | MohammadSadegh Sanie SeyedMmohammad Hoseinipanah Poran Hajian |
| author_sort | MohammadSadegh Sanie |
| collection | DOAJ |
| description | Introduction: Oxidative damage is one of the major factors that lead to cell damage, organ dysfunction and mortality in sepsis. Thus, an attractive candidate for pharmacologic treatment of the septic syndrome is deferoxamine (DFX), an antioxidant iron chelator used for the removal of iron and a potential free radical scavenger. In this study, the impact of DFX administration on the survival of septic animals was evaluated. Material and Methods: Sepsis was induced in 20 rats, using the Cecal Ligation and Puncture method (CLP) and 10 rats randomly received subcutaneous DFX (total dose: 40mg/kg) twice and the other 10 rats received placebo (normal saline). All the rats had equal health status, environment and nutrition. The time of the death of the rats was recorded. Results: Deferoxamine increased the survival period in rats and the difference was statistically significant. Conclusion: Treatment with DFX significantly increases the survival of septic rats. |
| first_indexed | 2024-12-21T14:16:08Z |
| format | Article |
| id | doaj.art-d5df85ba2bed4c7a9985161cc62f0896 |
| institution | Directory Open Access Journal |
| issn | 2008-7993 2008-8442 |
| language | fas |
| last_indexed | 2024-12-21T14:16:08Z |
| publishDate | 2012-04-01 |
| publisher | Jahrom University of Medical Sciences |
| record_format | Article |
| series | فصلنامه دانشگاه علوم پزشکی جهرم |
| spelling | doaj.art-d5df85ba2bed4c7a9985161cc62f08962022-12-21T19:00:54ZfasJahrom University of Medical Sciencesفصلنامه دانشگاه علوم پزشکی جهرم2008-79932008-84422012-04-0110116Growth indicators and related factors in children under 6 years in Shiraz city in 2008MohammadSadegh Sanie0SeyedMmohammad Hoseinipanah1Poran Hajian2 Dept. of Anesthesiology, School of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran Dept. of Anatomy, School of Medicine, Hamedan University of Medical Sciences, Hamedan, Iran Dept. of Anesthesiology, School of Medicine, Hamedan University of Medical Sciences, Hamedan, Iran Introduction: Oxidative damage is one of the major factors that lead to cell damage, organ dysfunction and mortality in sepsis. Thus, an attractive candidate for pharmacologic treatment of the septic syndrome is deferoxamine (DFX), an antioxidant iron chelator used for the removal of iron and a potential free radical scavenger. In this study, the impact of DFX administration on the survival of septic animals was evaluated. Material and Methods: Sepsis was induced in 20 rats, using the Cecal Ligation and Puncture method (CLP) and 10 rats randomly received subcutaneous DFX (total dose: 40mg/kg) twice and the other 10 rats received placebo (normal saline). All the rats had equal health status, environment and nutrition. The time of the death of the rats was recorded. Results: Deferoxamine increased the survival period in rats and the difference was statistically significant. Conclusion: Treatment with DFX significantly increases the survival of septic rats.http://jmj.jums.ac.ir/article-1-70-en.htmldeferoxaminesurvivalratsperitonitis |
| spellingShingle | MohammadSadegh Sanie SeyedMmohammad Hoseinipanah Poran Hajian Growth indicators and related factors in children under 6 years in Shiraz city in 2008 فصلنامه دانشگاه علوم پزشکی جهرم deferoxamine survival rats peritonitis |
| title | Growth indicators and related factors in children under 6 years in Shiraz city in 2008 |
| title_full | Growth indicators and related factors in children under 6 years in Shiraz city in 2008 |
| title_fullStr | Growth indicators and related factors in children under 6 years in Shiraz city in 2008 |
| title_full_unstemmed | Growth indicators and related factors in children under 6 years in Shiraz city in 2008 |
| title_short | Growth indicators and related factors in children under 6 years in Shiraz city in 2008 |
| title_sort | growth indicators and related factors in children under 6 years in shiraz city in 2008 |
| topic | deferoxamine survival rats peritonitis |
| url | http://jmj.jums.ac.ir/article-1-70-en.html |
| work_keys_str_mv | AT mohammadsadeghsanie growthindicatorsandrelatedfactorsinchildrenunder6yearsinshirazcityin2008 AT seyedmmohammadhoseinipanah growthindicatorsandrelatedfactorsinchildrenunder6yearsinshirazcityin2008 AT poranhajian growthindicatorsandrelatedfactorsinchildrenunder6yearsinshirazcityin2008 |