Clinical Application of Cardiac Magnetic Resonance in ART-Treated AIDS Males with Short Disease Duration
Cardiac complications are common in antiretroviral therapy-treated (ART-treated) acquired immune deficiency syndrome (AIDS) patients, and the incidence increases with age. Myocardial injury in ART-treated AIDS patients with a relatively longer disease duration has been evaluated. However, there is n...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/10/2417 |
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| author | Keke Hou Hang Fu Wei Xiong Yueqin Gao Liqiu Xie Jianglin He Xianbiao Feng Tao Zeng Lin Cai Lei Xiong Nan Jiang Min Jiang Bin Kang Haiyan Zheng Na Zhang Yingkun Guo |
| author_facet | Keke Hou Hang Fu Wei Xiong Yueqin Gao Liqiu Xie Jianglin He Xianbiao Feng Tao Zeng Lin Cai Lei Xiong Nan Jiang Min Jiang Bin Kang Haiyan Zheng Na Zhang Yingkun Guo |
| author_sort | Keke Hou |
| collection | DOAJ |
| description | Cardiac complications are common in antiretroviral therapy-treated (ART-treated) acquired immune deficiency syndrome (AIDS) patients, and the incidence increases with age. Myocardial injury in ART-treated AIDS patients with a relatively longer disease duration has been evaluated. However, there is no relevant study on whether patients with a short AIDS duration have cardiac dysfunction. Thirty-seven ART-treated males with AIDS and eighteen healthy controls (HCs) were prospectively included for CMR scanning. Clinical data and laboratory examination results were collected. The ART-treated males with AIDS did not have significantly reduced biventricular ejection fraction, myocardial edema, or late gadolinium enhancement. Compared with the HCs, the biventricular volume parameters and left ventricle myocardial strain indices in ART-treated males with AIDS were not significantly reduced (all <i>p</i> > 0.05). ART-treated males with AIDS were divided into subgroups according to their CD4+ T-cell counts (<350 cells/μL and ≥350 cells/μL) and duration of disease (1–12 months, 13–24 months, and 25–36 months). There was no significant decrease in left or right ventricular volume parameters or myocardial strain indices among the subgroups (all <i>p</i> > 0.05). In Pearson correlation analysis, CD4+ T-cell counts were not significantly correlated with biventricular volume parameters or left ventricular myocardial strain indices. In conclusion, ART-treated males with AIDS receiving ART therapy with a short disease duration (less than 3 years) might not develop obvious cardiac dysfunction as evaluated by routine CMR, so it is reasonable to appropriately extend the interval between cardiovascular follow-ups to more than 3 years. |
| first_indexed | 2024-03-09T20:22:43Z |
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| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T20:22:43Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-d5e26ed10ac24ef683fb31e29e3da47c2023-11-23T23:44:56ZengMDPI AGDiagnostics2075-44182022-10-011210241710.3390/diagnostics12102417Clinical Application of Cardiac Magnetic Resonance in ART-Treated AIDS Males with Short Disease DurationKeke Hou0Hang Fu1Wei Xiong2Yueqin Gao3Liqiu Xie4Jianglin He5Xianbiao Feng6Tao Zeng7Lin Cai8Lei Xiong9Nan Jiang10Min Jiang11Bin Kang12Haiyan Zheng13Na Zhang14Yingkun Guo15Department of Radiology, Public Health Clinical Center of Chengdu, Chengdu 610061, ChinaKey Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Department of Radiology, West China Second University Hospital, Sichuan University, 20# South Renmin Road, Chengdu 610017, ChinaDepartment of Radiology, Public Health Clinical Center of Chengdu, Chengdu 610061, ChinaDepartment of Radiology, Public Health Clinical Center of Chengdu, Chengdu 610061, ChinaDepartment of Radiology, Public Health Clinical Center of Chengdu, Chengdu 610061, ChinaDepartment of Radiology, Public Health Clinical Center of Chengdu, Chengdu 610061, ChinaDepartment of Radiology, Public Health Clinical Center of Chengdu, Chengdu 610061, ChinaDepartment of Ultrasound, Public Health Clinical Center of Chengdu, Chengdu 610061, ChinaDepartment of Infectious Disease, Public Health Clinical Center of Chengdu, Chengdu 610061, ChinaDepartment of Radiology, Public Health Clinical Center of Chengdu, Chengdu 610061, ChinaDepartment of Radiology, Public Health Clinical Center of Chengdu, Chengdu 610061, ChinaDepartment of Radiology, Public Health Clinical Center of Chengdu, Chengdu 610061, ChinaDepartment of Radiology, Public Health Clinical Center of Chengdu, Chengdu 610061, ChinaDepartment of Radiology, Public Health Clinical Center of Chengdu, Chengdu 610061, ChinaDepartment of Radiology, Public Health Clinical Center of Chengdu, Chengdu 610061, ChinaKey Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Department of Radiology, West China Second University Hospital, Sichuan University, 20# South Renmin Road, Chengdu 610017, ChinaCardiac complications are common in antiretroviral therapy-treated (ART-treated) acquired immune deficiency syndrome (AIDS) patients, and the incidence increases with age. Myocardial injury in ART-treated AIDS patients with a relatively longer disease duration has been evaluated. However, there is no relevant study on whether patients with a short AIDS duration have cardiac dysfunction. Thirty-seven ART-treated males with AIDS and eighteen healthy controls (HCs) were prospectively included for CMR scanning. Clinical data and laboratory examination results were collected. The ART-treated males with AIDS did not have significantly reduced biventricular ejection fraction, myocardial edema, or late gadolinium enhancement. Compared with the HCs, the biventricular volume parameters and left ventricle myocardial strain indices in ART-treated males with AIDS were not significantly reduced (all <i>p</i> > 0.05). ART-treated males with AIDS were divided into subgroups according to their CD4+ T-cell counts (<350 cells/μL and ≥350 cells/μL) and duration of disease (1–12 months, 13–24 months, and 25–36 months). There was no significant decrease in left or right ventricular volume parameters or myocardial strain indices among the subgroups (all <i>p</i> > 0.05). In Pearson correlation analysis, CD4+ T-cell counts were not significantly correlated with biventricular volume parameters or left ventricular myocardial strain indices. In conclusion, ART-treated males with AIDS receiving ART therapy with a short disease duration (less than 3 years) might not develop obvious cardiac dysfunction as evaluated by routine CMR, so it is reasonable to appropriately extend the interval between cardiovascular follow-ups to more than 3 years.https://www.mdpi.com/2075-4418/12/10/2417acquired immune deficiency syndromeCMRcardiovascular complications |
| spellingShingle | Keke Hou Hang Fu Wei Xiong Yueqin Gao Liqiu Xie Jianglin He Xianbiao Feng Tao Zeng Lin Cai Lei Xiong Nan Jiang Min Jiang Bin Kang Haiyan Zheng Na Zhang Yingkun Guo Clinical Application of Cardiac Magnetic Resonance in ART-Treated AIDS Males with Short Disease Duration Diagnostics acquired immune deficiency syndrome CMR cardiovascular complications |
| title | Clinical Application of Cardiac Magnetic Resonance in ART-Treated AIDS Males with Short Disease Duration |
| title_full | Clinical Application of Cardiac Magnetic Resonance in ART-Treated AIDS Males with Short Disease Duration |
| title_fullStr | Clinical Application of Cardiac Magnetic Resonance in ART-Treated AIDS Males with Short Disease Duration |
| title_full_unstemmed | Clinical Application of Cardiac Magnetic Resonance in ART-Treated AIDS Males with Short Disease Duration |
| title_short | Clinical Application of Cardiac Magnetic Resonance in ART-Treated AIDS Males with Short Disease Duration |
| title_sort | clinical application of cardiac magnetic resonance in art treated aids males with short disease duration |
| topic | acquired immune deficiency syndrome CMR cardiovascular complications |
| url | https://www.mdpi.com/2075-4418/12/10/2417 |
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