Determinação de olanzapina em formulações farmacêuticas por espectrofotometria: desenvolvimento e validação Spectrophotometric olanzapine determination in pharmaceutical formulations: method development and validation
<abstract language="eng">Spectrophotometric methods of zero order, first and second derived order had been developed for olanzapine determination in tablets using ethanol and isopropanol as solvent. The two solvents revealed to be adequate. For the three methods the calibration curve...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
2010-01-01
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| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000200041 |
| _version_ | 1818889661626449920 |
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| author | Jardes Figuerêdo do Rêgo Jacira Izidório de Moura Graziella Ciaramella Moita |
| author_facet | Jardes Figuerêdo do Rêgo Jacira Izidório de Moura Graziella Ciaramella Moita |
| author_sort | Jardes Figuerêdo do Rêgo |
| collection | DOAJ |
| description | <abstract language="eng">Spectrophotometric methods of zero order, first and second derived order had been developed for olanzapine determination in tablets using ethanol and isopropanol as solvent. The two solvents revealed to be adequate. For the three methods the calibration curve coefficient of correlation had been greater than 0.9998 with limit of detection varying from 0.068 to 0.190 mg L-1, in ethanol, and 0.026 to 0.205 mg L-1, in isopropanol. The inter-day precision was inferior to 1.1 and 1.9 mg L-1 for ethanol and isopropanol, respectively. The average recoveries varied from 98 to 101%, in ethanol and 99 to 103% in isopropanol. |
| first_indexed | 2024-12-19T17:12:34Z |
| format | Article |
| id | doaj.art-d5e32d2d849a4871a4aa11f629d804be |
| institution | Directory Open Access Journal |
| issn | 0100-4042 1678-7064 |
| language | English |
| last_indexed | 2024-12-19T17:12:34Z |
| publishDate | 2010-01-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-d5e32d2d849a4871a4aa11f629d804be2022-12-21T20:12:58ZengSociedade Brasileira de QuímicaQuímica Nova0100-40421678-70642010-01-0133247147710.1590/S0100-40422010000200041Determinação de olanzapina em formulações farmacêuticas por espectrofotometria: desenvolvimento e validação Spectrophotometric olanzapine determination in pharmaceutical formulations: method development and validationJardes Figuerêdo do RêgoJacira Izidório de MouraGraziella Ciaramella Moita<abstract language="eng">Spectrophotometric methods of zero order, first and second derived order had been developed for olanzapine determination in tablets using ethanol and isopropanol as solvent. The two solvents revealed to be adequate. For the three methods the calibration curve coefficient of correlation had been greater than 0.9998 with limit of detection varying from 0.068 to 0.190 mg L-1, in ethanol, and 0.026 to 0.205 mg L-1, in isopropanol. The inter-day precision was inferior to 1.1 and 1.9 mg L-1 for ethanol and isopropanol, respectively. The average recoveries varied from 98 to 101%, in ethanol and 99 to 103% in isopropanol.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000200041olanzapineUV spectrophotometryvalidation |
| spellingShingle | Jardes Figuerêdo do Rêgo Jacira Izidório de Moura Graziella Ciaramella Moita Determinação de olanzapina em formulações farmacêuticas por espectrofotometria: desenvolvimento e validação Spectrophotometric olanzapine determination in pharmaceutical formulations: method development and validation Química Nova olanzapine UV spectrophotometry validation |
| title | Determinação de olanzapina em formulações farmacêuticas por espectrofotometria: desenvolvimento e validação Spectrophotometric olanzapine determination in pharmaceutical formulations: method development and validation |
| title_full | Determinação de olanzapina em formulações farmacêuticas por espectrofotometria: desenvolvimento e validação Spectrophotometric olanzapine determination in pharmaceutical formulations: method development and validation |
| title_fullStr | Determinação de olanzapina em formulações farmacêuticas por espectrofotometria: desenvolvimento e validação Spectrophotometric olanzapine determination in pharmaceutical formulations: method development and validation |
| title_full_unstemmed | Determinação de olanzapina em formulações farmacêuticas por espectrofotometria: desenvolvimento e validação Spectrophotometric olanzapine determination in pharmaceutical formulations: method development and validation |
| title_short | Determinação de olanzapina em formulações farmacêuticas por espectrofotometria: desenvolvimento e validação Spectrophotometric olanzapine determination in pharmaceutical formulations: method development and validation |
| title_sort | determinacao de olanzapina em formulacoes farmaceuticas por espectrofotometria desenvolvimento e validacao spectrophotometric olanzapine determination in pharmaceutical formulations method development and validation |
| topic | olanzapine UV spectrophotometry validation |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000200041 |
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