Application and progress of the detection technologies in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) has a very high incidence and fatality rate, and in most cases, it is already at an advanced stage when diagnosed. Therefore, early prevention and detection of HCC are two of the most effective strategies. However, the methods recommended in the practice guidelines for...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2023-09-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304222001003 |
| _version_ | 1797782715831943168 |
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| author | Qi Yan Yuan-song Sun Ran An Fang Liu Qi Fang Zhen Wang Tao Xu Lijian Chen Jian Du |
| author_facet | Qi Yan Yuan-song Sun Ran An Fang Liu Qi Fang Zhen Wang Tao Xu Lijian Chen Jian Du |
| author_sort | Qi Yan |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) has a very high incidence and fatality rate, and in most cases, it is already at an advanced stage when diagnosed. Therefore, early prevention and detection of HCC are two of the most effective strategies. However, the methods recommended in the practice guidelines for the detection of HCC cannot guarantee high sensitivity and specificity except for the liver biopsy, which is known as the “gold standard”. In this review, we divided the detection of HCC into pre-treatment diagnosis and post-treatment monitoring, and found that in addition to the traditional imaging detection and liver biopsy, alpha fetoprotein (AFP), lens culinaris-agglutinin-reactive fraction of AFP (AFP-L3), protein induced by vitamin K absence or antagonist-II (PIVKA-II) and other biomarkers are excellent biomarkers for HCC, especially when they are combined together. Most notably, the emerging liquid biopsy shows great promise in detecting HCC. In addition, lactic dehydrogenase (LDH), suppressor of cytokine signaling (SOCS) and other relevant biomarkers may become promising biomarkers for HCC post-treatment monitoring. Through the detailed introduction of the diagnostic technology of HCC, we can have a detailed understanding of its development process and then obtain some enlightenment from the diagnosis, to improve the diagnostic rate of HCC and reduce its mortality. |
| first_indexed | 2024-03-13T00:14:54Z |
| format | Article |
| id | doaj.art-d5e6c79ab52c424299b08588972aef8e |
| institution | Directory Open Access Journal |
| issn | 2352-3042 |
| language | English |
| last_indexed | 2024-03-13T00:14:54Z |
| publishDate | 2023-09-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj.art-d5e6c79ab52c424299b08588972aef8e2023-07-12T04:19:35ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422023-09-0110518571869Application and progress of the detection technologies in hepatocellular carcinomaQi Yan0Yuan-song Sun1Ran An2Fang Liu3Qi Fang4Zhen Wang5Tao Xu6Lijian Chen7Jian Du8School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui 230032, ChinaDepartment of Emergency Surgery, The Second Hospital of Anhui Medical University, Hefei, Anhui 230032, ChinaSchool of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui 230032, ChinaSchool of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui 230032, ChinaDepartment of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, ChinaDepartment of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, ChinaInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Hefei, Anhui 230032, China; Institute for Liver Diseases of Anhui Medical University, Anhui Medical University, Hefei, Anhui 230032, China; Corresponding author. School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China.Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, China; Corresponding author.School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui 230032, China; Corresponding author. School of Basic Medical Sciences, Anhui Medical University, No.81 Meishan Road, Hefei, Anhui 230032, China.Hepatocellular carcinoma (HCC) has a very high incidence and fatality rate, and in most cases, it is already at an advanced stage when diagnosed. Therefore, early prevention and detection of HCC are two of the most effective strategies. However, the methods recommended in the practice guidelines for the detection of HCC cannot guarantee high sensitivity and specificity except for the liver biopsy, which is known as the “gold standard”. In this review, we divided the detection of HCC into pre-treatment diagnosis and post-treatment monitoring, and found that in addition to the traditional imaging detection and liver biopsy, alpha fetoprotein (AFP), lens culinaris-agglutinin-reactive fraction of AFP (AFP-L3), protein induced by vitamin K absence or antagonist-II (PIVKA-II) and other biomarkers are excellent biomarkers for HCC, especially when they are combined together. Most notably, the emerging liquid biopsy shows great promise in detecting HCC. In addition, lactic dehydrogenase (LDH), suppressor of cytokine signaling (SOCS) and other relevant biomarkers may become promising biomarkers for HCC post-treatment monitoring. Through the detailed introduction of the diagnostic technology of HCC, we can have a detailed understanding of its development process and then obtain some enlightenment from the diagnosis, to improve the diagnostic rate of HCC and reduce its mortality.http://www.sciencedirect.com/science/article/pii/S2352304222001003HCCInvasive diagnosisMinimally invasive diagnosisNoninvasive diagnosisPrognostic monitoring |
| spellingShingle | Qi Yan Yuan-song Sun Ran An Fang Liu Qi Fang Zhen Wang Tao Xu Lijian Chen Jian Du Application and progress of the detection technologies in hepatocellular carcinoma Genes and Diseases HCC Invasive diagnosis Minimally invasive diagnosis Noninvasive diagnosis Prognostic monitoring |
| title | Application and progress of the detection technologies in hepatocellular carcinoma |
| title_full | Application and progress of the detection technologies in hepatocellular carcinoma |
| title_fullStr | Application and progress of the detection technologies in hepatocellular carcinoma |
| title_full_unstemmed | Application and progress of the detection technologies in hepatocellular carcinoma |
| title_short | Application and progress of the detection technologies in hepatocellular carcinoma |
| title_sort | application and progress of the detection technologies in hepatocellular carcinoma |
| topic | HCC Invasive diagnosis Minimally invasive diagnosis Noninvasive diagnosis Prognostic monitoring |
| url | http://www.sciencedirect.com/science/article/pii/S2352304222001003 |
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