State of Knowledge on the Acquisition, Diversity, Interspecies Attribution and Spread of Antimicrobial Resistance between Humans, Animals and the Environment: A Systematic Review
Resistance to antibiotics is considered one of the most urgent global public health concerns. It has considerable impacts on health and the economy, being responsible for the failure to treat infectious diseases, higher morbidity and mortality rates, and rising health costs. In spite of the joint re...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/12/1/73 |
| _version_ | 1797446998506340352 |
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| author | Hélène Meier Keira Spinner Lisa Crump Esther Kuenzli Gertraud Schuepbach Jakob Zinsstag |
| author_facet | Hélène Meier Keira Spinner Lisa Crump Esther Kuenzli Gertraud Schuepbach Jakob Zinsstag |
| author_sort | Hélène Meier |
| collection | DOAJ |
| description | Resistance to antibiotics is considered one of the most urgent global public health concerns. It has considerable impacts on health and the economy, being responsible for the failure to treat infectious diseases, higher morbidity and mortality rates, and rising health costs. In spite of the joint research efforts between different humans, animals and the environment, the key directions and dynamics of the spread of antimicrobial resistance (AMR) still remain unclear. The aim of this systematic review is to examine the current knowledge of AMR acquisition, diversity and the interspecies spread of disease between humans, animals and the environment. Using a systematic literature review, based on a One Health approach, we examined articles investigating AMR bacteria acquisition, diversity, and the interspecies spread between humans, animals and the environment. Water was the environmental sector most often represented. Samples were derived from 51 defined animal species and/or their products A large majority of studies investigated clinical samples of the human population. A large variety of 15 different bacteria genera in three phyla (Proteobacteria, Firmicutes and Actinobacteria) were investigated. The majority of the publications compared the prevalence of pheno- and/or genotypic antibiotic resistance within the different compartments. There is evidence for a certain host or compartment specificity, regarding the occurrence of ARGs/AMR bacteria. This could indicate the rather limited AMR spread between different compartments. Altogether, there remains a very fragmented and incomplete understanding of AMR acquisition, diversity, and the interspecies spread between humans, animals and the environment. Stringent One Health epidemiological study designs are necessary for elucidating the principal routes and dynamics of the spread of AMR bacteria between humans, animals and the environment. This knowledge is an important prerequisite to develop effective public health measures to tackle the alarming AMR situation. |
| first_indexed | 2024-03-09T13:48:32Z |
| format | Article |
| id | doaj.art-d5e6fcb0426246a9ad6a22e6bb957b41 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T13:48:32Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-d5e6fcb0426246a9ad6a22e6bb957b412023-11-30T20:55:19ZengMDPI AGAntibiotics2079-63822022-12-011217310.3390/antibiotics12010073State of Knowledge on the Acquisition, Diversity, Interspecies Attribution and Spread of Antimicrobial Resistance between Humans, Animals and the Environment: A Systematic ReviewHélène Meier0Keira Spinner1Lisa Crump2Esther Kuenzli3Gertraud Schuepbach4Jakob Zinsstag5Institute of Veterinary Public Health, Vetsuisse Faculty, University of Berne, Schwarzenburgstr. 155, CH-3097 Liebefeld, SwitzerlandDepartment of Health Sciences and Technology, Eidgenössische Technische Hochschule (ETH) Zürich, Rämistrasse 101, CH-8092 Zurich, SwitzerlandUniversity of Basel, Petersplatz 1, CH-4003 Basel, SwitzerlandUniversity of Basel, Petersplatz 1, CH-4003 Basel, SwitzerlandInstitute of Veterinary Public Health, Vetsuisse Faculty, University of Berne, Schwarzenburgstr. 155, CH-3097 Liebefeld, SwitzerlandUniversity of Basel, Petersplatz 1, CH-4003 Basel, SwitzerlandResistance to antibiotics is considered one of the most urgent global public health concerns. It has considerable impacts on health and the economy, being responsible for the failure to treat infectious diseases, higher morbidity and mortality rates, and rising health costs. In spite of the joint research efforts between different humans, animals and the environment, the key directions and dynamics of the spread of antimicrobial resistance (AMR) still remain unclear. The aim of this systematic review is to examine the current knowledge of AMR acquisition, diversity and the interspecies spread of disease between humans, animals and the environment. Using a systematic literature review, based on a One Health approach, we examined articles investigating AMR bacteria acquisition, diversity, and the interspecies spread between humans, animals and the environment. Water was the environmental sector most often represented. Samples were derived from 51 defined animal species and/or their products A large majority of studies investigated clinical samples of the human population. A large variety of 15 different bacteria genera in three phyla (Proteobacteria, Firmicutes and Actinobacteria) were investigated. The majority of the publications compared the prevalence of pheno- and/or genotypic antibiotic resistance within the different compartments. There is evidence for a certain host or compartment specificity, regarding the occurrence of ARGs/AMR bacteria. This could indicate the rather limited AMR spread between different compartments. Altogether, there remains a very fragmented and incomplete understanding of AMR acquisition, diversity, and the interspecies spread between humans, animals and the environment. Stringent One Health epidemiological study designs are necessary for elucidating the principal routes and dynamics of the spread of AMR bacteria between humans, animals and the environment. This knowledge is an important prerequisite to develop effective public health measures to tackle the alarming AMR situation.https://www.mdpi.com/2079-6382/12/1/73anti-bacterial agentdrug resistancebacterialdrug resistancemicrobialresistome |
| spellingShingle | Hélène Meier Keira Spinner Lisa Crump Esther Kuenzli Gertraud Schuepbach Jakob Zinsstag State of Knowledge on the Acquisition, Diversity, Interspecies Attribution and Spread of Antimicrobial Resistance between Humans, Animals and the Environment: A Systematic Review Antibiotics anti-bacterial agent drug resistance bacterial drug resistance microbial resistome |
| title | State of Knowledge on the Acquisition, Diversity, Interspecies Attribution and Spread of Antimicrobial Resistance between Humans, Animals and the Environment: A Systematic Review |
| title_full | State of Knowledge on the Acquisition, Diversity, Interspecies Attribution and Spread of Antimicrobial Resistance between Humans, Animals and the Environment: A Systematic Review |
| title_fullStr | State of Knowledge on the Acquisition, Diversity, Interspecies Attribution and Spread of Antimicrobial Resistance between Humans, Animals and the Environment: A Systematic Review |
| title_full_unstemmed | State of Knowledge on the Acquisition, Diversity, Interspecies Attribution and Spread of Antimicrobial Resistance between Humans, Animals and the Environment: A Systematic Review |
| title_short | State of Knowledge on the Acquisition, Diversity, Interspecies Attribution and Spread of Antimicrobial Resistance between Humans, Animals and the Environment: A Systematic Review |
| title_sort | state of knowledge on the acquisition diversity interspecies attribution and spread of antimicrobial resistance between humans animals and the environment a systematic review |
| topic | anti-bacterial agent drug resistance bacterial drug resistance microbial resistome |
| url | https://www.mdpi.com/2079-6382/12/1/73 |
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