Correlates of Elevated Interleukin-6 and 8-Hydroxy-2′-Deoxyguanosine Levels in Tracheal Aspirates from Very Low Birth Weight Infants Who Develop Bronchopulmonary Dysplasia
Bronchopulmonary dysplasia (BPD) remains the most common complication of very low birth weight (VLBW) preterm infants, and inflammatory regulation plays a role in the development of the BPD. Interleukin-6 (IL-6) has an important role in airway inflammation and therefore can be used as a marker of ai...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-02-01
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| Series: | Pediatrics and Neonatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957216300602 |
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| author | Chien-Chou Hsiao Jui-Chih Chang Lon-Yen Tsao Rei-Cheng Yang Hsiao-Neng Chen Cheng-Han Lee Ching-Yuang Lin Yi-Giien Tsai |
| author_facet | Chien-Chou Hsiao Jui-Chih Chang Lon-Yen Tsao Rei-Cheng Yang Hsiao-Neng Chen Cheng-Han Lee Ching-Yuang Lin Yi-Giien Tsai |
| author_sort | Chien-Chou Hsiao |
| collection | DOAJ |
| description | Bronchopulmonary dysplasia (BPD) remains the most common complication of very low birth weight (VLBW) preterm infants, and inflammatory regulation plays a role in the development of the BPD. Interleukin-6 (IL-6) has an important role in airway inflammation and therefore can be used as a marker of airway injury. The study aimed to compare the changes between IL-6 and oxidative stress marker with 8-hydroxy-2′-deoxyguanosine (8-OHdG) from serum and tracheal aspiration (TA) in VLBW preterm infants following development of BPD.
Methods: This birth cohort study enrolled 80 VLBW preterm infants, including 26 who developed BPD. All infants completed the study and survived at 36 weeks postmenstrual age. IL-6 and 8-OHdG concentrations from serum and TA on Day 1 and Day 28 after birth were measured using immunoassay.
Results: IL-6 and 8-OHdG in serum and TA were higher in the BPD group than in the non-BPD group on the 1st day after birth (p < 0.05). The IL-6 and 8-OHdG levels in TA fluid were persistently increased on the 28th day of life in the BPD group (p < 0.05). The TA IL-6 was positively correlated with 8-OHdG levels on the 1st day (r = 0.64, p < 0.05) and 28th day of life (r = 0.76, p < 0.05). Based on receiver operating characteristic curves as a predictor of BPD development, TA IL-6 (cutoff, 456.8 pg/mg) had 81.5% sensitivity and 77.8% specificity, whereas TA 8-OHdG (cutoff, 4.4 ng/mg) had a sensitivity of 81.5% and a specificity of 64.4%.
Conclusion: Persistent inflammation with oxidative DNA damage in the respiratory tract may be a crucial mechanism in BPD. |
| first_indexed | 2024-12-23T11:52:58Z |
| format | Article |
| id | doaj.art-d5e7d57fdd554be5899a6dc0cc4fe314 |
| institution | Directory Open Access Journal |
| issn | 1875-9572 |
| language | English |
| last_indexed | 2024-12-23T11:52:58Z |
| publishDate | 2017-02-01 |
| publisher | Elsevier |
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| series | Pediatrics and Neonatology |
| spelling | doaj.art-d5e7d57fdd554be5899a6dc0cc4fe3142022-12-21T17:48:09ZengElsevierPediatrics and Neonatology1875-95722017-02-01581636910.1016/j.pedneo.2016.01.004Correlates of Elevated Interleukin-6 and 8-Hydroxy-2′-Deoxyguanosine Levels in Tracheal Aspirates from Very Low Birth Weight Infants Who Develop Bronchopulmonary DysplasiaChien-Chou Hsiao0Jui-Chih Chang1Lon-Yen Tsao2Rei-Cheng Yang3Hsiao-Neng Chen4Cheng-Han Lee5Ching-Yuang Lin6Yi-Giien Tsai7Department of Pediatrics, Changhua Christian Children's Hospital, Changhua City, TaiwanVascular and Genomic Research Center, Changhua Christian Hospital, Changhua City, TaiwanDepartment of Pediatrics, Changhua Christian Children's Hospital, Changhua City, TaiwanDepartment of Pediatrics, Changhua Christian Children's Hospital, Changhua City, TaiwanDepartment of Pediatrics, Changhua Christian Children's Hospital, Changhua City, TaiwanDepartment of Pediatrics, Changhua Christian Children's Hospital, Changhua City, TaiwanDepartment of Pediatrics, Children's Hospital, China Medical University, Taichung City, TaiwanDepartment of Pediatrics, Changhua Christian Children's Hospital, Changhua City, TaiwanBronchopulmonary dysplasia (BPD) remains the most common complication of very low birth weight (VLBW) preterm infants, and inflammatory regulation plays a role in the development of the BPD. Interleukin-6 (IL-6) has an important role in airway inflammation and therefore can be used as a marker of airway injury. The study aimed to compare the changes between IL-6 and oxidative stress marker with 8-hydroxy-2′-deoxyguanosine (8-OHdG) from serum and tracheal aspiration (TA) in VLBW preterm infants following development of BPD. Methods: This birth cohort study enrolled 80 VLBW preterm infants, including 26 who developed BPD. All infants completed the study and survived at 36 weeks postmenstrual age. IL-6 and 8-OHdG concentrations from serum and TA on Day 1 and Day 28 after birth were measured using immunoassay. Results: IL-6 and 8-OHdG in serum and TA were higher in the BPD group than in the non-BPD group on the 1st day after birth (p < 0.05). The IL-6 and 8-OHdG levels in TA fluid were persistently increased on the 28th day of life in the BPD group (p < 0.05). The TA IL-6 was positively correlated with 8-OHdG levels on the 1st day (r = 0.64, p < 0.05) and 28th day of life (r = 0.76, p < 0.05). Based on receiver operating characteristic curves as a predictor of BPD development, TA IL-6 (cutoff, 456.8 pg/mg) had 81.5% sensitivity and 77.8% specificity, whereas TA 8-OHdG (cutoff, 4.4 ng/mg) had a sensitivity of 81.5% and a specificity of 64.4%. Conclusion: Persistent inflammation with oxidative DNA damage in the respiratory tract may be a crucial mechanism in BPD.http://www.sciencedirect.com/science/article/pii/S18759572163006028-hydroxydeoxyguanosinebronchopulmonary dysplasiapremature infant |
| spellingShingle | Chien-Chou Hsiao Jui-Chih Chang Lon-Yen Tsao Rei-Cheng Yang Hsiao-Neng Chen Cheng-Han Lee Ching-Yuang Lin Yi-Giien Tsai Correlates of Elevated Interleukin-6 and 8-Hydroxy-2′-Deoxyguanosine Levels in Tracheal Aspirates from Very Low Birth Weight Infants Who Develop Bronchopulmonary Dysplasia Pediatrics and Neonatology 8-hydroxydeoxyguanosine bronchopulmonary dysplasia premature infant |
| title | Correlates of Elevated Interleukin-6 and 8-Hydroxy-2′-Deoxyguanosine Levels in Tracheal Aspirates from Very Low Birth Weight Infants Who Develop Bronchopulmonary Dysplasia |
| title_full | Correlates of Elevated Interleukin-6 and 8-Hydroxy-2′-Deoxyguanosine Levels in Tracheal Aspirates from Very Low Birth Weight Infants Who Develop Bronchopulmonary Dysplasia |
| title_fullStr | Correlates of Elevated Interleukin-6 and 8-Hydroxy-2′-Deoxyguanosine Levels in Tracheal Aspirates from Very Low Birth Weight Infants Who Develop Bronchopulmonary Dysplasia |
| title_full_unstemmed | Correlates of Elevated Interleukin-6 and 8-Hydroxy-2′-Deoxyguanosine Levels in Tracheal Aspirates from Very Low Birth Weight Infants Who Develop Bronchopulmonary Dysplasia |
| title_short | Correlates of Elevated Interleukin-6 and 8-Hydroxy-2′-Deoxyguanosine Levels in Tracheal Aspirates from Very Low Birth Weight Infants Who Develop Bronchopulmonary Dysplasia |
| title_sort | correlates of elevated interleukin 6 and 8 hydroxy 2 deoxyguanosine levels in tracheal aspirates from very low birth weight infants who develop bronchopulmonary dysplasia |
| topic | 8-hydroxydeoxyguanosine bronchopulmonary dysplasia premature infant |
| url | http://www.sciencedirect.com/science/article/pii/S1875957216300602 |
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