Clinical characteristics of acute pancreatitis in children: a single-center experience in Western China
Abstract Background The diagnosis of pediatric pancreatitis has been increasing over the last 20 years. We aimed to compare the clinical characteristics for pediatric acute pancreatitis (AP) with adult AP, and investigate the risk factor for acute recurrent pancreatitis (ARP) in children. Method Fro...
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| Format: | Article |
| Language: | English |
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BMC
2021-03-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-021-01706-8 |
| _version_ | 1818615429008982016 |
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| author | Rui Zhong Shali Tan Yan Peng Huan Xu Xin Jiang Yongfeng Yan Muhan Lv Li Liu Xiaowei Tang |
| author_facet | Rui Zhong Shali Tan Yan Peng Huan Xu Xin Jiang Yongfeng Yan Muhan Lv Li Liu Xiaowei Tang |
| author_sort | Rui Zhong |
| collection | DOAJ |
| description | Abstract Background The diagnosis of pediatric pancreatitis has been increasing over the last 20 years. We aimed to compare the clinical characteristics for pediatric acute pancreatitis (AP) with adult AP, and investigate the risk factor for acute recurrent pancreatitis (ARP) in children. Method From June 2013 to June 2019, a total of 130 pediatric patients with AP at the inpatient database were enrolled. Univariate analysis and multivariate Cox regression analysis were performed to identify the risk factors for ARP in children. Result Major etiologic factors in 130 patients were biliary (31.5%), idiopathic (28.5%). The etiology of pancreatitis in children was markedly different from that in adults (p < 0.001). Compared with the adult patients, the pediatric patients had significantly lower severity (p = 0.018) and occurrence rate of pancreatic necrosis (p = 0.041), SIRS (p = 0.021), acute peripancreatic fluid collection (p = 0.014). Univariate and Multivariate Cox regression analysis showed that female (p = 0.020; OR 3.821; 95% CI 1.231–11.861), hypertriglyceridemia (p = 0.045; OR 3.111; 95% CI 1.024–9.447), pancreatic necrosis (p = 0.023; OR 5.768; 95% CI 1.278–26.034) were the independent risk factors of ARP. Hypertriglyceridemia AP had the highest risk of recurrence compared to other etiology (p = 0.035). Conclusion Biliary and idiopathic disease were the major etiologies of AP in children. Children have simpler conditions than adults. Female, hypertriglyceridemia, and pancreatic necrosis were associated with the onset of ARP. |
| first_indexed | 2024-12-16T16:33:46Z |
| format | Article |
| id | doaj.art-d5eab7edeb5b4e5c8c0123369ca6d621 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-12-16T16:33:46Z |
| publishDate | 2021-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-d5eab7edeb5b4e5c8c0123369ca6d6212022-12-21T22:24:31ZengBMCBMC Gastroenterology1471-230X2021-03-012111710.1186/s12876-021-01706-8Clinical characteristics of acute pancreatitis in children: a single-center experience in Western ChinaRui Zhong0Shali Tan1Yan Peng2Huan Xu3Xin Jiang4Yongfeng Yan5Muhan Lv6Li Liu7Xiaowei Tang8Department of Gastroenterology, The Affiliated Hospital of Southwest Medical UniversityDepartment of Gastroenterology, The Affiliated Hospital of Southwest Medical UniversityDepartment of Gastroenterology, The Affiliated Hospital of Southwest Medical UniversityDepartment of Gastroenterology, The Affiliated Hospital of Southwest Medical UniversityDepartment of Gastroenterology, The Affiliated Hospital of Southwest Medical UniversityDepartment of Gastroenterology, The Affiliated Hospital of Southwest Medical UniversityDepartment of Gastroenterology, The Affiliated Hospital of Southwest Medical UniversityDepartment of Digestive Endoscopy, The First Affiliated Hospital With Nanjing Medical UniversityDepartment of Gastroenterology, The Affiliated Hospital of Southwest Medical UniversityAbstract Background The diagnosis of pediatric pancreatitis has been increasing over the last 20 years. We aimed to compare the clinical characteristics for pediatric acute pancreatitis (AP) with adult AP, and investigate the risk factor for acute recurrent pancreatitis (ARP) in children. Method From June 2013 to June 2019, a total of 130 pediatric patients with AP at the inpatient database were enrolled. Univariate analysis and multivariate Cox regression analysis were performed to identify the risk factors for ARP in children. Result Major etiologic factors in 130 patients were biliary (31.5%), idiopathic (28.5%). The etiology of pancreatitis in children was markedly different from that in adults (p < 0.001). Compared with the adult patients, the pediatric patients had significantly lower severity (p = 0.018) and occurrence rate of pancreatic necrosis (p = 0.041), SIRS (p = 0.021), acute peripancreatic fluid collection (p = 0.014). Univariate and Multivariate Cox regression analysis showed that female (p = 0.020; OR 3.821; 95% CI 1.231–11.861), hypertriglyceridemia (p = 0.045; OR 3.111; 95% CI 1.024–9.447), pancreatic necrosis (p = 0.023; OR 5.768; 95% CI 1.278–26.034) were the independent risk factors of ARP. Hypertriglyceridemia AP had the highest risk of recurrence compared to other etiology (p = 0.035). Conclusion Biliary and idiopathic disease were the major etiologies of AP in children. Children have simpler conditions than adults. Female, hypertriglyceridemia, and pancreatic necrosis were associated with the onset of ARP.https://doi.org/10.1186/s12876-021-01706-8Acute pancreatitisAcute recurrent pancreatitisChildEtiology |
| spellingShingle | Rui Zhong Shali Tan Yan Peng Huan Xu Xin Jiang Yongfeng Yan Muhan Lv Li Liu Xiaowei Tang Clinical characteristics of acute pancreatitis in children: a single-center experience in Western China BMC Gastroenterology Acute pancreatitis Acute recurrent pancreatitis Child Etiology |
| title | Clinical characteristics of acute pancreatitis in children: a single-center experience in Western China |
| title_full | Clinical characteristics of acute pancreatitis in children: a single-center experience in Western China |
| title_fullStr | Clinical characteristics of acute pancreatitis in children: a single-center experience in Western China |
| title_full_unstemmed | Clinical characteristics of acute pancreatitis in children: a single-center experience in Western China |
| title_short | Clinical characteristics of acute pancreatitis in children: a single-center experience in Western China |
| title_sort | clinical characteristics of acute pancreatitis in children a single center experience in western china |
| topic | Acute pancreatitis Acute recurrent pancreatitis Child Etiology |
| url | https://doi.org/10.1186/s12876-021-01706-8 |
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