Differential interaction patterns of opioid analgesics with µ opioid receptors correlate with ligand-specific voltage sensitivity

Differential interaction patterns of opioid analgesics with µ opioid receptors correlate with ligand-specific voltage sensitivity

The µ opioid receptor (MOR) is the key target for analgesia, but the application of opioids is accompanied by several issues. There is a wide range of opioid analgesics, differing in their chemical structure and their properties of receptor activation and subsequent effects. A better understanding o...

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Bibliographic Details
Main Authors: Sina B Kirchhofer, Victor Jun Yu Lim, Sebastian Ernst, Noemi Karsai, Julia G Ruland, Meritxell Canals, Peter Kolb, Moritz Bünemann
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-11-01
Series:eLife
Subjects:
voltage
GPCR
ligands
opioid
Förster resonance energy transfer
binding mode
Online Access:https://elifesciences.org/articles/91291

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