Importance of <i>NUDT15</i> Polymorphisms in Thiopurine Treatments
Thiopurines, mercaptopurine, and azathioprine are used as immunosuppressants in the treatments of inflammatory bowel disease, rheumatoid arthritis, and organ transplantation and as chemotherapeutic drugs for the treatment of acute leukemia and chronic myeloid leukemia. This drug class sometimes caus...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/11/8/778 |
| _version_ | 1797523297703821312 |
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| author | Yoichi Tanaka Yoshiro Saito |
| author_facet | Yoichi Tanaka Yoshiro Saito |
| author_sort | Yoichi Tanaka |
| collection | DOAJ |
| description | Thiopurines, mercaptopurine, and azathioprine are used as immunosuppressants in the treatments of inflammatory bowel disease, rheumatoid arthritis, and organ transplantation and as chemotherapeutic drugs for the treatment of acute leukemia and chronic myeloid leukemia. This drug class sometimes causes severe adverse reactions, including bone marrow suppression and hair loss. Genetic polymorphisms of the metabolizing enzyme thiopurine S-methyltransferase have been used for predicting these reactions in Caucasians, but these allele frequencies are less frequently observed in Asian populations. Recently, nudix hydrolase 15 (<i>NUDT15</i>) polymorphisms have been shown to play an important role in thiopurine-induced adverse reactions in Asians. In this review, we summarize the <i>NUDT15</i> studies, mainly in Asian countries, and their implementation in several countries. |
| first_indexed | 2024-03-10T08:41:23Z |
| format | Article |
| id | doaj.art-d5ebaa4655bd4d5099432abe931e90bb |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T08:41:23Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-d5ebaa4655bd4d5099432abe931e90bb2023-11-22T08:19:14ZengMDPI AGJournal of Personalized Medicine2075-44262021-08-0111877810.3390/jpm11080778Importance of <i>NUDT15</i> Polymorphisms in Thiopurine TreatmentsYoichi Tanaka0Yoshiro Saito1Division of Medicinal Safety Science, National Institute of Health Sciences, Kawasaki City 210-9501, Kanagawa, JapanDivision of Medicinal Safety Science, National Institute of Health Sciences, Kawasaki City 210-9501, Kanagawa, JapanThiopurines, mercaptopurine, and azathioprine are used as immunosuppressants in the treatments of inflammatory bowel disease, rheumatoid arthritis, and organ transplantation and as chemotherapeutic drugs for the treatment of acute leukemia and chronic myeloid leukemia. This drug class sometimes causes severe adverse reactions, including bone marrow suppression and hair loss. Genetic polymorphisms of the metabolizing enzyme thiopurine S-methyltransferase have been used for predicting these reactions in Caucasians, but these allele frequencies are less frequently observed in Asian populations. Recently, nudix hydrolase 15 (<i>NUDT15</i>) polymorphisms have been shown to play an important role in thiopurine-induced adverse reactions in Asians. In this review, we summarize the <i>NUDT15</i> studies, mainly in Asian countries, and their implementation in several countries.https://www.mdpi.com/2075-4426/11/8/778<i>NUDT15</i>thiopurinemercaptopurineazathioprineAsianadverse effect |
| spellingShingle | Yoichi Tanaka Yoshiro Saito Importance of <i>NUDT15</i> Polymorphisms in Thiopurine Treatments Journal of Personalized Medicine <i>NUDT15</i> thiopurine mercaptopurine azathioprine Asian adverse effect |
| title | Importance of <i>NUDT15</i> Polymorphisms in Thiopurine Treatments |
| title_full | Importance of <i>NUDT15</i> Polymorphisms in Thiopurine Treatments |
| title_fullStr | Importance of <i>NUDT15</i> Polymorphisms in Thiopurine Treatments |
| title_full_unstemmed | Importance of <i>NUDT15</i> Polymorphisms in Thiopurine Treatments |
| title_short | Importance of <i>NUDT15</i> Polymorphisms in Thiopurine Treatments |
| title_sort | importance of i nudt15 i polymorphisms in thiopurine treatments |
| topic | <i>NUDT15</i> thiopurine mercaptopurine azathioprine Asian adverse effect |
| url | https://www.mdpi.com/2075-4426/11/8/778 |
| work_keys_str_mv | AT yoichitanaka importanceofinudt15ipolymorphismsinthiopurinetreatments AT yoshirosaito importanceofinudt15ipolymorphismsinthiopurinetreatments |