Ellagic acid improves benign prostate hyperplasia by regulating androgen signaling and STAT3
Abstracts Benign prostate hyperplasia (BPH) is an age-related disease in men characterized by the growth of prostate cells and hyperproliferation of prostate tissue. This condition is closely related to chronic inflammation. In this study, we highlight the therapeutic efficacy of ellagic acid (EA) f...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2022-06-01
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| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-022-04995-3 |
| _version_ | 1811344960734101504 |
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| author | Woo Yong Park Gahee Song Ja Yeon Park Kwang Seok Ahn Hyun Jeong Kwak Jinbong Park Jun Hee Lee Jae-Young Um |
| author_facet | Woo Yong Park Gahee Song Ja Yeon Park Kwang Seok Ahn Hyun Jeong Kwak Jinbong Park Jun Hee Lee Jae-Young Um |
| author_sort | Woo Yong Park |
| collection | DOAJ |
| description | Abstracts Benign prostate hyperplasia (BPH) is an age-related disease in men characterized by the growth of prostate cells and hyperproliferation of prostate tissue. This condition is closely related to chronic inflammation. In this study, we highlight the therapeutic efficacy of ellagic acid (EA) for BPH by focusing on the AR signaling axis and STAT3. To investigate the effect of EA on BPH, we used EA, a phytochemical abundant in fruits and vegetables, to treat testosterone propionate (TP)-induced BPH rats and RWPE-1 human prostate epithelial cells. The EA treatment reduced prostate weight, prostate epithelial thickness, and serum DHT levels in the TP-induced BPH rat model. In addition, EA improved testicular injury by increasing antioxidant enzymes in testis of the BPH rats. EA reduced the protein levels of AR, 5AR2, and PSA. It also induced apoptosis by regulating Bax, Bcl_xL, cytochrome c, caspase 9, and caspase 3 with increasing mitochondrial dynamics. Furthermore, EA reduced the expression of IL-6, TNF-α, and NF-κB, as well as phosphorylation of STAT3 and IκBα. These findings were also confirmed in TP-treated RWPE-1 cells. Overall, our data provide evidence of the role of EA in improving BPH through inhibition of AR and the STAT3 pathway. |
| first_indexed | 2024-04-13T19:55:55Z |
| format | Article |
| id | doaj.art-d5ebaa6d72da4935bccc2d724578829f |
| institution | Directory Open Access Journal |
| issn | 2041-4889 |
| language | English |
| last_indexed | 2024-04-13T19:55:55Z |
| publishDate | 2022-06-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death and Disease |
| spelling | doaj.art-d5ebaa6d72da4935bccc2d724578829f2022-12-22T02:32:21ZengNature Publishing GroupCell Death and Disease2041-48892022-06-0113611110.1038/s41419-022-04995-3Ellagic acid improves benign prostate hyperplasia by regulating androgen signaling and STAT3Woo Yong Park0Gahee Song1Ja Yeon Park2Kwang Seok Ahn3Hyun Jeong Kwak4Jinbong Park5Jun Hee Lee6Jae-Young Um7Department of Science in Korean Medicine, Graduate School, Kyung Hee UniversityDepartment of Science in Korean Medicine, Graduate School, Kyung Hee UniversityDepartment of Science in Korean Medicine, Graduate School, Kyung Hee UniversityDepartment of Science in Korean Medicine, Graduate School, Kyung Hee UniversityDepartment of Life Science, College of Natural Sciences, Kyonggi UniversityDepartment of Pharmacology, College of Korean Medicine, Kyung Hee UniversityDepartment of Sasang Constitutional Medicine, College of Korean Medicine, Kyung Hee UniversityDepartment of Science in Korean Medicine, Graduate School, Kyung Hee UniversityAbstracts Benign prostate hyperplasia (BPH) is an age-related disease in men characterized by the growth of prostate cells and hyperproliferation of prostate tissue. This condition is closely related to chronic inflammation. In this study, we highlight the therapeutic efficacy of ellagic acid (EA) for BPH by focusing on the AR signaling axis and STAT3. To investigate the effect of EA on BPH, we used EA, a phytochemical abundant in fruits and vegetables, to treat testosterone propionate (TP)-induced BPH rats and RWPE-1 human prostate epithelial cells. The EA treatment reduced prostate weight, prostate epithelial thickness, and serum DHT levels in the TP-induced BPH rat model. In addition, EA improved testicular injury by increasing antioxidant enzymes in testis of the BPH rats. EA reduced the protein levels of AR, 5AR2, and PSA. It also induced apoptosis by regulating Bax, Bcl_xL, cytochrome c, caspase 9, and caspase 3 with increasing mitochondrial dynamics. Furthermore, EA reduced the expression of IL-6, TNF-α, and NF-κB, as well as phosphorylation of STAT3 and IκBα. These findings were also confirmed in TP-treated RWPE-1 cells. Overall, our data provide evidence of the role of EA in improving BPH through inhibition of AR and the STAT3 pathway.https://doi.org/10.1038/s41419-022-04995-3 |
| spellingShingle | Woo Yong Park Gahee Song Ja Yeon Park Kwang Seok Ahn Hyun Jeong Kwak Jinbong Park Jun Hee Lee Jae-Young Um Ellagic acid improves benign prostate hyperplasia by regulating androgen signaling and STAT3 Cell Death and Disease |
| title | Ellagic acid improves benign prostate hyperplasia by regulating androgen signaling and STAT3 |
| title_full | Ellagic acid improves benign prostate hyperplasia by regulating androgen signaling and STAT3 |
| title_fullStr | Ellagic acid improves benign prostate hyperplasia by regulating androgen signaling and STAT3 |
| title_full_unstemmed | Ellagic acid improves benign prostate hyperplasia by regulating androgen signaling and STAT3 |
| title_short | Ellagic acid improves benign prostate hyperplasia by regulating androgen signaling and STAT3 |
| title_sort | ellagic acid improves benign prostate hyperplasia by regulating androgen signaling and stat3 |
| url | https://doi.org/10.1038/s41419-022-04995-3 |
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